Fgf21
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Official Full Name
fibroblast growth factor 21
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Overview
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008] -
Synonyms
FGF21; fibroblast growth factor 21;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- GMP Proteins
- Cell & Tissue Lysates
- Bovine
- Cynomolgus Monkey
- Human
- Mouse
- Pig
- Rat
- Zebrafish
- Bovine
- CHO
- E. coli
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Fc
- Flag
- GST
- HIS
- His (Fc)
- Avi
- His(C
- ter)
- His|S
- mFc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Fgf21 Related Articles
- Fgf21 Related Research Area
- Fgf21 Related Signal Pathway
Fgf21 involved in several pathways and played different roles in them. We selected most pathways Fgf21 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgf21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | FGF6;DUSP16;TGFBR1B;NTF3;TP53;CACNG7;LRRK2;CACNA2D4;HSP70 |
Ras signaling pathway | GNGT1;Pdgfa&Pdgfb;NGF;FGF19;GNG4;CALM3;RASGRF2;Fgf15;PLA2G1B |
Rap signaling pathway | PLCG1;Itgam&Itgb2;MAPK12;PRKCI;ANGPT4;PIK3R1;BCAR1;FGF18;AKT1 |
PIK-Akt signaling pathway | SYK;HSP90AA1;GHR;HSP90AB1;GNB4;IFNA12;ITGA8;AKT1;NRAS |
Regulation of actin cytoskeleton | ROCK1;ITGA10;GNG12;MYL12.2;GSN;VCL;Itga10&Itgb1;RASSF7;ACTB1 |
Pathways in cancer | BDKRB1;WNT10B;TGFB2;GNA11;CASP9;LPAR2;FGF9;APC;KIT |
Melanoma | PDGFB;FGF14;IGF1R;TRP53;PIK3R1;AKT2;FGF16;MDM2;TP53 |
Fgf21 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgf21 itself. We selected most functions Fgf21 had, and list some proteins which have the same functions with Fgf21. You can find most of the proteins on our site.
Function | Related Protein |
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fibroblast growth factor receptor binding | FGF2;FGF1;FGF9;FGF6B;FGF22;FGF10A;KLB;FRS2;FGF18A |
growth factor activity | NDR1;FGF11;INHBAA;AREG;FGF18;VEGFAA;CSF1B;CLEC11A;PSPN |
protein binding | STK4;PPP2CB;CHTOP;HDDC3;DDX3X;NXT1;KATNAL1;PPP1R37;Chrng |
Fgf21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgf21 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgf21.
KLB; CDC25A; MAPK7; TNS2; CDH7
- Q&As
- Reviews
Q&As (7)
Ask a questionFGF21 expression in adipose tissue is regulated by various factors, including peroxisome proliferator-activated receptor gamma (PPARγ) activation.
FGF21 influences lipid metabolism by promoting the utilization of fatty acids for energy, contributing to the regulation of lipid homeostasis.
FGF21 levels are being explored as potential biomarkers for metabolic health, reflecting conditions such as insulin resistance and metabolic syndrome.
Yes, FGF21 plays a role in improving insulin sensitivity, making it a potential target for interventions in insulin resistance-associated conditions.
Yes, FGF21 influences energy expenditure by promoting thermogenesis in brown adipose tissue, contributing to overall metabolic regulation.
Gender-specific differences in FGF21 levels have been reported, with some studies suggesting higher circulating FGF21 concentrations in females.
FGF21 activates signaling pathways such as the AMP-activated protein kinase (AMPK) pathway, which contributes to its metabolic effects.
Customer Reviews (3)
Write a reviewThe manufacturer's history of producing high-quality products contributed to our trust in this protein.
Collaboration with other research groups was made easier by the product's standardized use in the scientific community.
The product's role in promoting collaboration and teamwork positively impacted the quality of our research.
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