fgf21
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  • Official Full Name
  • fibroblast growth factor 21
  • Background
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FGF21; fibroblast growth factor 21;
Cat.#:FGF21-1966HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGF21 Protein, MYC/DDK-tagged
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Cat.#:FGF21-4111HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGF21 Protein, GST-tagged
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Cat.#:FGF21-103HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor 21
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Cat.#:FGF21-104HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF21, His-tagged
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Cat.#:FGF21-133HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF21 Protein, His-tagged
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Cat.#:FGF21-192HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF21 protein, His/S-tagged
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Cat.#:FGF21-28827THTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGF21, His-tagged
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Cat.#:FGF21-28828THTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGF21, FLAG-tagged
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Cat.#:FGF21-28829THTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGF21, Fc-tagged
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Cat.#:FGF21-562HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF21
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Cat.#:FGF21-564HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF21, His tagged
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Cat.#:Fgf21-109MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor 21
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Cat.#:Fgf21-110MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor 21, His-tagged
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Cat.#:Fgf21-193MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fgf21 protein, His/S-tagged
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Cat.#:Fgf21-256MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgf21, FLAG-tagged
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Cat.#:Fgf21-258MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgf21, Fc-tagged
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Cat.#:FGF21-36MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse FGF21 Protein, His-tagged
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Cat.#:Fgf21-414MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor 21, FLAG-tagged
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Cat.#:Fgf21-563MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fgf21
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Cat.#:Fgf21-574MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgf21, His tagged
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Cat.#:Fgf21-194RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa protein, His/S-tagged
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Cat.#:Fgf21-589RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgf21
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Cat.#:FGF21-1236CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FGF21 Protein, His-tagged
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Cat.#:FGF21-4310ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGF21
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Cat.#:Fgf21-503MTag:HIS
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fgf21, His-tagged
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Cat.#:Fgf21-504MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fgf21
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Cat.#:FGF21-626BTag:N/A
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine Fibroblast Growth Factor 21
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Cat.#:FGF21-1890MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FGF21 cell lysate
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Involved Pathway

Fgf21 involved in several pathways and played different roles in them. We selected most pathways Fgf21 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgf21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RASGRF2B; NTRK2B; FGF20; GADD45AB; NFATC3; PPM1B; CACNA1SA; RPS6KA2; PPP3CCA; CASP3B
Ras signaling pathway
STK4; PDGFB; CALML5; KLK1B4; FGF14; FGFR3; RELA; ETS1; FGFR1; INS
Rap signaling pathway
MAGI1; PIK3R5; RAP1B; PLCB1; ACTB; CALM1; MAP2K2; PARD6B; NRAS; GRIN2B
PIK-Akt signaling pathway
TNXB; SGK1; GRB2; IL7; FGF20; PPP2R2B; VEGFA; PDGFRA; YWHAH; FGF3
Regulation of actin cytoskeleton
MOS; PIP4K2B; FGFR1A; SOS1; FGF21; BDKRB1; SSH3; APC2; SRC; MAP2K2
Pathways in cancer
BIRC5; PTK2; CXCR4; RXRA; MAPK10; PDGFRA; DAPK1; PTGER3; GLI1; GNAI1
Melanoma
PDGFRA; PIK3CB; FGF14; Fgf15; ARAF; IGF1; FGF13; AKT2; PIK3R1; FGF4

Protein Function

Fgf21 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgf21 itself. We selected most functions Fgf21 had, and list some proteins which have the same functions with Fgf21. You can find most of the proteins on our site.
Function
Related Protein
Function fibroblast growth factor receptor binding
Related Protein FGF20A; FGF20B; FGF10B; Fgf15; FRS3; FGF4; FGF8A; FGF18B; FGF1; FGF6A
Function growth factor activity
Related Protein IGF2B; AMELX; TDGF1; PTN; Il2; GDF7; BMP8A; CNTF; FGF1; MSTNA
Function protein binding
Related Protein GTF2H2C_2; PIGK; CDK1; ACAT2; RASL11A; MCPH1; TYK2; UBE2N; TTYH2; LXN

Interacting Protein

Fgf21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgf21 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgf21.
KLB; CDC25A; MAPK7; TNS2; CDH7

Fgf21 Related Articles

Zhang, J; Li, Y; et al. Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. DRUG DISCOVERY TODAY 19:579-589(2014).
Umberger, TS; Sloan, JH; et al. Novel sandwich immunoassays for the measurement of total and active FGF21. BIOANALYSIS 6:3283-3293(2014).