CCL5

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CCL5

Official Full Name chemokine (C-C motif) ligand 5
Background This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Synonyms CCL5; chemokine (C-C motif) ligand 5; SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta; C-C motif chemokine 5; beta-chemokine RANTES; T-cell specific protein p288; eosinophil chemotactic cytokine; small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted;
    • Species :
    • Bovine
    • Chicken
    • Cotton Rat
    • Cynomolgus Monkey
    • Dog
    • Guinea pig
    • Horse
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Swine
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Mouse
    • NSO
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • S
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Ccl5-133M Recombinant Mouse Ccl5 Protein E.coli
    Mouse Ccl5-2039M Recombinant Mouse Ccl5 Protein E. coli
    Mouse Ccl5-2040M Recombinant Mouse Ccl5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CCL5-2625H Recombinant Human CCL5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Rat CCL5-312R Recombinant Rat CCL5 Protein, His-tagged Yeast His
    Rhesus CCL5-3411R Recombinant Rhesus CCL5 protein E.coli N/A
    Human CCL5-513HG GMP Recombinant Human CCL5 protein, Fc-tagged HEK293 Fc
    Human CCL5-0642H Recombinant Human CCL5 Protein, GST-Tagged Wheat Germ GST
    Human CCL5-114H Human CCL5 N/A
    Human CCL5-120H Human Rantes (rDNA derived) Reference standard N/A
    Human CCL5-125H Recombinant Human Chemokine (C-C Motif) Ligand 5 NSO N/A
    Human CCL5-2706HCL Recombinant Human CCL5 cell lysate Human Cell N/A
    Human CCL5-301H Recombinant Human CCL5 protein E.coli N/A
    Human CCL5-510H Recombinant Mouse Chemokine (C-C motif) Ligand 5, MIgG2a Fc-tagged CHO Fc
    Human CCL5-511H Recombinant Mouse Chemokine (C-C motif) Ligand 5, HIgG1 Fc-tagged, mutant CHO Fc
    Human CCL5-512H Recombinant Mouse Chemokine (C-C motif) Ligand 5, HIgG1 Fc-tagged CHO Fc
    Human CCL5-61H Recombinant Human chemokine (C-C motif) ligand 5, His-tagged E.coli His
    Human CCL5-773H Recombinant Human CCL5 protein, His & T7-tagged E.coli His/T7
    Human CCL5-81H Recombinant Human CCL5 protein HEK293 N/A
    Human CCL5-82H Recombinant Human CCL5 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CCL5-85H Recombinant Human CCL5, His tagged Human Cell His
    Mouse Ccl5-259M Recombinant Mouse Chemokine (C-C motif) Ligand 5 Mouse N/A
    Mouse CCL5-2977M Recombinant Mouse CCL5 Protein Mammalian Cell His
    Mouse Ccl5-616M Recombinant Mouse Ccl5 protein E.coli N/A
    Mouse Ccl5-774M Recombinant Mouse Ccl5 protein, His & GST-tagged E.coli His/GST
    Rat Ccl5-104R Recombinant Rat Chemokine (C-C Motif) Ligand 5 E.coli N/A
    Cynomolgus Monkey CCL5-4397C Recombinant Cynomolgus Monkey CCL5 Protein Yeast N/A
    Rhesus Macaque CCL5-693R Recombinant Rhesus monkey CCL5 Protein, His-tagged Mammalian Cell His
    Rhesus monkey CCL5-776R Recombinant Rhesus monkey CCL5 protein, His-tagged E.coli His
    Dog CCL5-770D Recombinant Dog CCL5 protein, His & S-tagged E.coli His/S
    Bovine CCL5-132B Recombinant Bovine Chemokine (C-C motif) Ligand 5 Yeast N/A
    Chicken CCL5-3492C Recombinant Chicken CCL5 Mammalian Cell His
    Rabbit CCL5-4353R Recombinant Rabbit CCL5 Protein Yeast N/A
    Pig CCL5-147S Recombinant Swine Chemokine (C-C motif) Ligand 5 Yeast N/A
    Pig CCL5-22S Recombinant Swine CCL5 Yeast N/A
    Cotton Rat Ccl5-385C Recombinant Cotton Rat Ccl5 E.coli N/A
    Swine CCL5-4354S Recombinant Swine CCL5 Protein Yeast N/A
    Horse CCL5-771H Recombinant Horse CCL5 protein, His & T7-tagged E.coli His/T7
    Guinea pig Ccl5-772G Recombinant Guinea pig Ccl5 protein, His & GST-tagged E.coli His/GST
    Pig CCL5-775P Recombinant Pig CCL5 protein, His & T7-tagged E.coli His/T7

    CCL5 involved in several pathways and played different roles in them. We selected most pathways CCL5 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction EDA2R; XCR1; TNFRSF13C; CCR1; LEPB; IL9R; CD40LG; CCL28; IFNA8; TNFRSF8
    Chemokine signaling pathway PRKCZ; CCL7; CCL8; PXN; GM10591; RLN1; GNG11; CCL18; GNB1; SHC2
    Toll-like receptor signaling pathway AKT3A; TRAF6; Ifna11; MAP2K2A; MAPK12A; PIK3R5; MAP2K7; IFNAR2; NFKBIAB; CD80
    NOD-like receptor signaling pathway CCL2; CASPA; LOC100033925; IL6; NAIP6; CCL5; MAPK14A; MAPK12; MAPK1; CASP5
    Cytosolic DNA-sensing pathway POLR2L; POLR2K; MAVS; TREX1; Ifna15; POLR3GL; IKBKE; POLR3A; POLR3E; AIM2
    TNF signaling pathway MAPK9; SELE; CREB3L3; MAPK3; VCAM1; IKBKG; IL18R1; SOCS3; FAS; RELA
    Prion diseases MAPK3; PRKACA; IL1A; CCL5; C8G; MAP2K1; C6; HSPA1A; HSPA5; ELK1
    Epithelial cell signaling in Helicobacter pylori infection ATP6AP1; PAK1; ATP6V0E1; RELA; MAPK9; ATP6V0A1; ATP6V1A; MAPK13; ATP6V0A2; ATP6V1H
    Chagas disease (American trypanosomiasis) GNA14; C1QA; MYD88; CD247; FASLG; GNAS; IFNGR1; AKT2; CD3D; IL12A
    Influenza A MAP2K4; TNF; IL1A; HLA-DPB1; PRKCB; NXF2; HSPA1L; IFNB1; DNAJB1; TNFRSF10D
    Herpes simplex infection TAF3; TRAF5; PTPN11; PER1A; POU2F3; TBPL1; MHC2A; FAS; H2-AB1; IFNPHI3
    Rheumatoid arthritis HLA-DRB3; ATP6V0A1; HLA-DMA; ATP6V1E1; Ctsl; CXCL1; HLA-DPA1; CCL3; TNFSF11; IL23

    CCL5 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR4 chemokine receptor binding, CCR5 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL5 itself. We selected most functions CCL5 had, and list some proteins which have the same functions with CCL5. You can find most of the proteins on our site.

    Function Related Protein
    CCR1 chemokine receptor binding CCL23; CCL5; CREB3; CCL3; CCL4; CCL7
    CCR4 chemokine receptor binding CCL5
    CCR5 chemokine receptor binding CNIH4; JAK1; STAT3; CCL4; CCL3; CCL5
    chemoattractant activity CCL16; VEGFB; CXCL12; FGF2; SAA4; LGALS3; SAA2; SCG2; SAA3; NTF3
    chemokine activity CCL22; CXCL19; CXCL6; CCL34B.9; CCL19A.1; CCL6; CCL33.2; CCL23; CCL21; CCL21B
    chemokine receptor antagonist activity CCL5
    chemokine receptor binding CCL25; CCL21B; Ccl21a; S100A14; XCL1; Ccl21c; CCRL2; CCL21; CXCL12; CCL5
    heparin binding LPL; ADAMTSL5; Itgam&Itgb2; APP; FBLN7; CTSG; AAMP; TGFBR3; POSTN; NAV2
    phosphatidylinositol phospholipase C activity BDKRB2; EDNRA; PLCG1; PLCZ1; PLCD1; PLCD1B; C3AR1; PLCG2; PLCH1; CCKBR
    phospholipase activator activity CCL5; APOC2; ARHGAP6; CCL3; CCL8; GM2A; PDPK1
    protein binding ZFYVE16; GEMIN6; YY1; EPN3; AVPR1A; SCYL2; HIST1H1C; IL17A; MUC2; SPATA13
    protein homodimerization activity Trl; DMRT1; ABCD1; COMMD1; NLRC4; IL12B; CD4; PVALB; PRMT8; SLC4A1
    protein kinase activity KDRL; MAP2K4A; FGFR1A; PRKG1A; IRAK1; PRKCBB; COL4A3BP; ERBB4A; RPS6KAL; PAN3
    protein self-association NKX3-1; CCL5; CCDC88C; DYRK1A; L1CAM; CTSC; ABCD3; PTH1R; TNFAIP3; TMEM43
    receptor signaling protein tyrosine kinase activator activity CCL5

    CCL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL5.

    DPP4; CCR5; BCAR3; BAG4; CHEK2; KRAS; TGFB1; CDH1; PTPN1; WT1; SLC2A5; APC; PHB; RANGAP1; RELA; TRIP6

    Yin, Q; Fan, Q; et al. Spinal NF-kappa B and Chemokine Ligand 5 Expression during Spinal Glial Cell Activation in a Neuropathic Pain Model. PLOS ONE 10:-(2015).
    Ricciardi, A; Dalton, JP; et al. Evaluation of the immune response and protective efficacy of Schistosoma mansoni Cathepsin B in mice using CpG dinucleotides as adjuvant. VACCINE 33:346-353(2015).

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