ccl5
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  • Official Full Name
  • chemokine (C-C motif) ligand 5
  • Background
  • This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
  • Synonyms
  • CCL5; chemokine (C-C motif) ligand 5; SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta; C-C motif chemokine 5; beta-chemokine RANTES; T-cell specific protein p288; eosinophil chemotactic cytokine; small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted;
Cat.#:CCL5-312RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat CCL5 Protein, His-tagged
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Cat.#:CCL5-0642HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCL5 Protein, GST-Tagged
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Cat.#:CCL5-4397CTag:N/A
Source (Host):YeastSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey CCL5 Protein
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Cat.#:CCL5-4353RTag:N/A
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit CCL5 Protein
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Cat.#:CCL5-4354STag:N/A
Source (Host):YeastSpecies:Swine
Product nameRecombinant Swine CCL5 Protein
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Cat.#:Ccl5-259MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-C motif) Ligand 5
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Cat.#:CCL5-3411RTag:N/A
Source (Host):E.coliSpecies:Rhesus
Product nameRecombinant Rhesus CCL5 protein
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Cat.#:CCL5-114HTag:N/A
Source (Host):Species:Human
Product nameHuman CCL5
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Cat.#:CCL5-301HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human CCL5 protein
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Cat.#:CCL5-510HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Mouse Chemokine (C-C motif) Ligand 5, MIgG2a Fc-tagged
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Cat.#:CCL5-511HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Mouse Chemokine (C-C motif) Ligand 5, HIgG1 Fc-tagged, mutant
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Cat.#:CCL5-512HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Mouse Chemokine (C-C motif) Ligand 5, HIgG1 Fc-tagged
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Cat.#:CCL5-773HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCL5 protein, His & T7-tagged
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Cat.#:CCL5-81HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCL5 protein
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Cat.#:CCL5-82HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCL5 protein, MYC/DDK-tagged
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Cat.#:CCL5-85HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCL5, His tagged
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Cat.#:CCL5-2977MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCL5 Protein
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Cat.#:Ccl5-616MTag:N/A
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse Ccl5 protein
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Cat.#:Ccl5-774MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccl5 protein, His & GST-tagged
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Cat.#:CCL5-693RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCL5 Protein, His-tagged
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Cat.#:CCL5-776RTag:His
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey CCL5 protein, His-tagged
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Cat.#:CCL5-770DTag:His|S
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog CCL5 protein, His & S-tagged
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Cat.#:CCL5-3492CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCL5
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Cat.#:CCL5-22STag:N/A
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine CCL5
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Cat.#:Ccl5-385CTag:N/A
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Ccl5
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Cat.#:CCL5-771HTag:His|T7
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse CCL5 protein, His & T7-tagged
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Cat.#:Ccl5-772GTag:His|GST
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Ccl5 protein, His & GST-tagged
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Cat.#:CCL5-775PTag:His|T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig CCL5 protein, His & T7-tagged
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Cat.#:CCL5-125HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Chemokine (C-C Motif) Ligand 5
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Cat.#:CCL5-61HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human chemokine (C-C motif) ligand 5, His-tagged
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Cat.#:Ccl5-104RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Chemokine (C-C Motif) Ligand 5
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Cat.#:CCL5-132BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Chemokine (C-C motif) Ligand 5
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Cat.#:CCL5-147STag:N/A
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine Chemokine (C-C motif) Ligand 5
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Cat.#:CCL5-2706HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCL5 cell lysate
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Cat.#:CCL5-120HTag:N/A
Source (Host):Species:Human
Product nameHuman Rantes (rDNA derived) Reference standard
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Involved Pathway

CCL5 involved in several pathways and played different roles in them. We selected most pathways CCL5 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
NGFRB; TNFRSF13C; IRX1; CCR8L; Il23a; Il12b; CTF1; GH2; IFNL3; OSTN; PDGFA
Chemokine signaling pathway
CCL2; CCR1L1; CCL24; STAT2; CXCR2; CCL8; CXCR3; GRK5; IKBKB; ITK
Toll-like receptor signaling pathway
MAPK3; TRAF6; CCL4; IL1B; LY96; CCL3L1; MAP2K7; IFNA4; LBP; IFNPHI1
NOD-like receptor signaling pathway
CXCL2; PYCARD; CXCL1; NFKBIA; MAP3K7IP3; LOC100033925; MAPK10; NFKBIAB; IL-8; CASPA
Cytosolic DNA-sensing pathway
TMEM173; IFN-a; Ifna11; LOC100033925; IKBKG; IRF3; NFKBIA; NFKBIAA; DDX58; NFKB1
TNF signaling pathway
VCAM1; MMP14; SOCS3; MAP2K1; CXCL3; CREB3L3; CXCL1; CCL5; PIK3R1; CCL2
Prion diseases
NCAM2; FYN; C8B; MAP2K1; Hc; C1QC; PRKACA; CCL5; STIP1; MAPK3
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1C2; ATP6V1E2; ATP6V1C1; CXCR2; ATP6V1B2; IKBKG; MAP2K4; ATP6AP1; ATP6V0B; ATP6V0A2
Chagas disease (American trypanosomiasis)
GNAI3; CCL2; IFNGR2; CCL3L1; PIK3CG; CD3G; PIK3R2; IL1B2; MAPK13; MAPK8
Influenza A
IFNB1; CXCL10; EIF2AK1; PIK3R3; XPO1; IFNA21; IFNAR2; HLA-DMB; IFIH1; HSPA6
Herpes simplex infection
HCFC1A; IRF3; SFRS3B; GTF2I; MAP3K7; IFNPHI1; CDC34; MYD88; TNFRSF1A; HNRNPK
Rheumatoid arthritis
ATP6AP1; MMP3; HLA-DQB1; HLA-DMB; CCL20; CCL3L1; ATP6V1D; IL6; Il23a; ATP6V0D2

Protein Function

CCL5 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR4 chemokine receptor binding, CCR5 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL5 itself. We selected most functions CCL5 had, and list some proteins which have the same functions with CCL5. You can find most of the proteins on our site.
Function
Related Protein
Function CCR1 chemokine receptor binding
Related Protein CCL5; CCL3; CCL23; CREB3; CCL7; CCL4
Function CCR4 chemokine receptor binding
Related Protein CCL5
Function CCR5 chemokine receptor binding
Related Protein CCL4; CCL3; CNIH4; JAK1; STAT3; CCL5
Function chemoattractant activity
Related Protein FGF8; MIF; PDGFB; BMP4; CCL3; VEGFA; CCL15; SCG2; HMGB1; HMGB2
Function chemokine activity
Related Protein CXCL12B; CXCL14; IL-8; Cxcl15; CCL5; CXCL12A; CCL18; CCL38A.4; CXCL8B.3; CCL13
Function chemokine receptor antagonist activity
Related Protein CCL5
Function chemokine receptor binding
Related Protein CCL25; CCL21; XCL1; CCRL2; Ccl21c; CCL5; CCL19; S100A14; Ccl21a; CCL21B
Function heparin binding
Related Protein RSPO3; VTN; LIPH; APPB; WISP1A; CCL2; NAV2; NELL2; APOH; RPL22
Function phosphatidylinositol phospholipase C activity
Related Protein PLCD3A; PLCZ1; PLCD3; PLCE1; PLCD1A; CHRM1; BDKRB2; CCL5; PLCG2; PLCH2
Function phospholipase activator activity
Related Protein PDPK1; CCL3; APOC2; CCL8; CCL5; GM2A; ARHGAP6
Function protein binding
Related Protein RNF10; FAM158A; ZNF180; ZBTB26; ZKSCAN4; NPM3; PUM2; ADAM10; KXD1; FAM134B
Function protein homodimerization activity
Related Protein RNF40; SFTPC; RPL7; FGFR1OP2; NTSR1; TENM1; AGR2; CPOX; GSTM4; Trl
Function protein kinase activity
Related Protein HIPK3A; MMD; PAN3; RPS6KB2; ACVR1; AURKC; CDC42BPB; EPHA4; ACVR2AA; AKT3A
Function protein self-association
Related Protein TNFAIP3; LDB1; L1CAM; TRP53; ADAM8; RYR2; ACVR2A; CCL5; RSAD2; SYP
Function receptor signaling protein tyrosine kinase activator activity
Related Protein CCL5

Interacting Protein

CCL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL5.
DPP4; CCR5; BCAR3; BAG4; CHEK2; KRAS; TGFB1; CDH1; PTPN1; WT1; SLC2A5; APC; PHB; RANGAP1; RELA; TRIP6

CCL5 Related Articles

Yin, Q; Fan, Q; et al. Spinal NF-kappa B and Chemokine Ligand 5 Expression during Spinal Glial Cell Activation in a Neuropathic Pain Model. PLOS ONE 10:-(2015).
Ricciardi, A; Dalton, JP; et al. Evaluation of the immune response and protective efficacy of Schistosoma mansoni Cathepsin B in mice using CpG dinucleotides as adjuvant. VACCINE 33:346-353(2015).

CCL5 Related Gene Family

GPCRs Chemokines Cytokines