cxcl1
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  • Official Full Name
  • chemokine (C-X-C motif) ligand 1
  • Background
  • This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
  • Synonyms
  • CXCL1; chemokine (C-X-C motif) ligand 1; KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1; growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; alpha-chemokine; secretory protein N51; C-X-C motif chemokine 1; platelet-derived growth factor-inducible protein KC;
Cat.#:CXCL1-2155HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCL1 Protein, GST-tagged
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Cat.#:CXCL1-982HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL1 Protein, His-SUMO-tagged
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Cat.#:CXCL1-334HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha)
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Cat.#:Cxcl1-377MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C motif) ligand 1, His-tagged
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Cat.#:Cxcl1-384MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C motif) Ligand 1
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Cat.#:Cxcl1-1877RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rattus Chemokine (C-X-C motif) Ligand 1 (melanoma growth stimulating activity, alpha)
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Cat.#:CXCL1-11715HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL1, His-tagged
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Cat.#:CXCL1-14HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C Motif) Ligand 1
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Cat.#:CXCL1-195HTag:His/NusA
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL1, His & NusA tagged
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Cat.#:CXCL1-222HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C Motif) Ligand 1, MIgG2a Fc-tagged
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Cat.#:CXCL1-233HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C Motif) Ligand 1,HIgG1 Fc-tagged, mutant
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Cat.#:CXCL1-244HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C Motif) Ligand 1, HIgG1 Fc-tagged
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Cat.#:CXCL1-281HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCL1, StrepII-tagged
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Cat.#:CXCL1-29095THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL1
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Cat.#:CXCL1-29096THTag:MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL1, MBP-tagged
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Cat.#:CXCL1-62HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 1 / Growth-regulated Alpha Protein, His-tagged
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Cat.#:CXCL1-769HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL1 protein, His & GST-tagged
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Cat.#:CXCL1-88HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C Motif) Ligand 1, His-tagged
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Cat.#:Cxcl1-15865MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl1, His-tagged
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Cat.#:Cxcl1-529MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Cxcl1 protein, His-tagged
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Cat.#:Cxcl1-770MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl1 protein, His & T7-tagged
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Cat.#:Cxcl1-771MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl1 protein, His & GST-tagged
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Cat.#:Cxcl1-772MTag:His/MBP
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl1 protein, His & MBP-tagged
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Cat.#:Cxcl1-96MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine C-X-C Motif Chemokine 1
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Cat.#:Cxcl1-1069RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl1 Protein
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Cat.#:CXCL1-1686RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CXCL1 Protein
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Cat.#:Cxcl1-773RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl1 protein, His-tagged
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Cat.#:Cxcl1-94RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Chemokine (C-X-C Motif) Ligand 1
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Cat.#:CXCL1-431CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CXCL1 Protein, His-tagged
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Cat.#:CXCL1-1104RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CXCL1 Protein, His-tagged
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Cat.#:Cxcl1-387CTag:
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Cxcl1
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Cat.#:CXCL1-27707THTag:
Source (Host):E. coliSpecies:Human
Product nameNative Human CXCL1
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Cat.#:CXCL1-425HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CXCL1 cell lysate
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Involved Pathway

CXCL1 involved in several pathways and played different roles in them. We selected most pathways CXCL1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCR7; CCL4L1; LEPB; TP-1; CX3CR1; CNTF; HGF; TNFRSF25; TNFRSF13C; CCL27
Chemokine signaling pathway
CCL15; GNB2; SHC1; STAT1; CXCR6; CCL22; CXCR5; CCL11; PLCB1; MAPK3
NOD-like receptor signaling pathway
MAPK13; PYCARD; IL18; TNFAIP3; CXCL8B.3; MAPK3; IKBKG; MAPK12A; NFKBIAB; RIPK2
TNF signaling pathway
MMP9; AKT1; PIK3R5; BIRC3; MMP14; TNF; BIRC2; ATF4; IKBKB; CASP8
Epithelial cell signaling in Helicobacter pylori infection
CCL5; LYN; ATP6V0E1; ATP6V1B2; ATP6V1G1; ATP6V1B1; GIT1; MAPK9; PLCG2; NFKB1
Salmonella infection
CXCL8B.3; PFN2L; DYNC1I2A; ROCK2; RAC1A; MAPK14B; MAPK3; KLC1A; RHOGB; PFN1
Legionellosis
EEF1A1; HSPA2; CXCL2; CASP9; CYCS; BCL2L13; IL6; HSPA6; HSF1; NAIP1
Amoebiasis
IFNG; SERPINB2; SERPINB6; C8A; TGFB3; CD1D; PIK3CA; MUC2; GM-CSF; ACTN1
Rheumatoid arthritis
MMP3; CXCL5; Il23a; Il12b; HLA-DRB1; IL11; CD28; Ccl12; CCL5; HLA-DRB5; CCL20

Protein Function

CXCL1 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL1 itself. We selected most functions CXCL1 had, and list some proteins which have the same functions with CXCL1. You can find most of the proteins on our site.
Function
Related Protein
Function CXCR chemokine receptor binding
Related Protein ITCH; CXCL3; PF4V1; IL8L2; CXCL12; AMCF-II; CXCL5; CXCL1; CXCL18B; CXCL20
Function chemokine activity
Related Protein CCL16; CCL26; CCL13; CXCL3; CXCL11.8; IL-8; CCL38.1; CCL25; CCL22; CCL17
Function enzyme activator activity
Related Protein PRKCE; UBA2; DBNL; LTC4S; DCP1B; MGST2; PITRM1; MMP24; SAE1; CASP9
Function growth factor activity
Related Protein CXCL12; OSM; NRTN; CLCF1; CSF3; CLEC11A; FGF4; FGF1A; BMP7B; VEGFAB
Function receptor binding
Related Protein NPFFL; Artn; HNF4A; AGRP; HLA-F; MAP7; ECI2; DECR2; HSPA1A; NPY

Interacting Protein

CXCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL1.
XRCC3; HRAS; ESR1; PTEN; purL

CXCL1 Related Articles

McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
Lee, YH; Shynlova, O; et al. Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation. CELLULAR & MOLECULAR IMMUNOLOGY 12:231-242(2015).

CXCL1 Related Gene Family

Chemokines Cytokines