erbb2
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  • Official Full Name
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • Background
  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog;
Cat.#:ERBB2-033HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 protein, Fc-tagged, APC labeled
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Cat.#:ERBB2-033HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 protein, Fc-tagged, R-PE labeled
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Cat.#:ERBB2-1110HTag:HlgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 Protein (Met1-Thr652), HlgG1 Fc-tagged, Biotinylated
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Cat.#:ERBB2-1216CATag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus ERBB2 protein, Fc-tagged, APC labeled
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Cat.#:ERBB2-1216CPTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus ERBB2 protein, Fc-tagged, R-PE labeled
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Cat.#:ERBB2-183HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 Protein, His-Avi-tagged, Biotinylated
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Cat.#:Erbb2-2514MATag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Erbb2 protein, Fc-tagged, APC labeled
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Cat.#:Erbb2-2514MPTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Erbb2 protein, Fc-tagged, R-PE labeled
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Cat.#:ERBB2-359HTag:Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 Protein, Strep-tagged
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Cat.#:ERBB2-360HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 Protein, His & Avi-tagged, Biotinylated
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Cat.#:Erbb2-4097RATag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb2 protein, Fc-tagged, APC labeled
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Cat.#:Erbb2-4097RPTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb2 protein, Fc-tagged, R-PE labeled
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Cat.#:ERBB2-40HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 protein, Fc-tagged, APC labeled
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Cat.#:ERBB2-40HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 protein, Fc-tagged, R-PE labeled
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Cat.#:ERBB2-41HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 protein, Fc-tagged, APC labeled
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Cat.#:ERBB2-41HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 protein, Fc-tagged, R-PE labeled
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Cat.#:ERBB2-552HATag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human ERBB2 protein, Fc-tagged, APC labeled
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Cat.#:ERBB2-552HPTag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human ERBB2 protein, Fc-tagged, R-PE labeled
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Cat.#:ERBB2-2118HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 Protein, MYC/DDK-tagged
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Cat.#:ERBB2-3441HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB2 Protein
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Cat.#:ERBB2-3442HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB2 Protein, GST-tagged
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Cat.#:ERBB2-3444HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ERBB2 Protein, GST-tagged
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Cat.#:Erbb2-2120RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Erbb2 Protein, His-tagged
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Cat.#:ERBB2-2515HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2
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Cat.#:ERBB2-033HTag:Fc
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ERBB2 Protein, Fc-tagged
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Cat.#:ERBB2-034HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ERBB2 Protein, His-tagged
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Cat.#:ERBB2-176HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB2 Protein, His & GST-tagged
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Cat.#:ERBB2-177HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 Protein
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Cat.#:ERBB2-182HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2, His-tagged, Biotinylated
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Cat.#:ERBB2-1893HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERBB2 protein, His & GST-tagged
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Cat.#:ERBB2-1894HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERBB2 protein, His & T7-tagged
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Cat.#:ERBB2-18HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human c-ERBB2
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Cat.#:ERBB2-200HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2, His-tagged, C13&N15 Labeled
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Cat.#:ERBB2-203HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 protein, DDK/His-tagged
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Cat.#:ERBB2-204HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB2 protein, DDK-tagged
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Cat.#:ERBB2-205HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB2 protein, DDK-tagged
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Cat.#:ERBB2-206HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ERBB2 protein, DDK-tagged
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Cat.#:ERBB2-207HTag:DDK
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ERBB2 protein, DDK-tagged
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Cat.#:ERBB2-211HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2, His-tagged
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Cat.#:ERBB2-229HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2, StrepII-tagged
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Cat.#:ERBB2-236HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2, C13&N15-labeled
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Cat.#:ERBB2-26845THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERBB2
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Cat.#:ERBB2-26846THTag:
Source (Host):Species:Human
Product nameRecombinant Human ERBB2
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Cat.#:ERBB2-28688THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ERBB2, GST-tagged
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Cat.#:ERBB2-328HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ERBB2, GST-tagged, Active
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Cat.#:ERBB2-3681HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human, ERBB2
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Cat.#:ERBB2-40HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 Protein, Fc-tagged
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Cat.#:ERBB2-41HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2, Fc tagged
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Cat.#:ERBB2-42HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HER2 Mutant (d755-759), GST-tagged
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Cat.#:ERBB2-43HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HER2 Mutant (G776VC), GST-tagged
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Cat.#:ERBB2-552HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human ERBB2 Protein, Fc Chimera
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Cat.#:ERBB2-60HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HER2 (A775_G776insYVMA), GST-tagged
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Cat.#:ERBB2-61HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human HER2 (V777_G778insCG), GST-tagged
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Cat.#:ERBB2-81HTag:FC/His
Source (Host):NS0Species:Human
Product nameRecombinant Human erbB-2, Fc-his-tag
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Cat.#:ERBB2-922HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2, His tagged
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Cat.#:Erbb2-1152MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Erbb2, His tagged
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Cat.#:Erbb2-1895MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Erbb2 protein, His & T7-tagged
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Cat.#:Erbb2-2514MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Erbb2, Fc tagged
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Cat.#:Erbb2-1896RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Erbb2 protein, His & GST-tagged
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Cat.#:Erbb2-4097RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb2, Fc tagged
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Cat.#:Erbb2-4098RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb2, His tagged
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Cat.#:Erbb2-4099RTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Erbb2, None tagged
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Cat.#:ERBB2-1216CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ERBB2 Protein, Fc-tagged
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Cat.#:ERBB2-1217CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ERBB2 Protein, His-tagged
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Cat.#:ERBB2-206CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ERBB2, His-tagged
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Cat.#:ERBB2-4112RTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB2, Fc tagged
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Cat.#:ERBB2-4113RTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB2, His tagged
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Cat.#:ERBB2-171CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine ERBB2, His-tagged
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Cat.#:ERBB2-3453CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ERBB2
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Cat.#:ERBB2-10470ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ERBB2
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Cat.#:ERBB2-01Tag:
Source (Host):E. coliSpecies:
Product nameRecombinant HER2/neu (478-584)
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Cat.#:ERBB2-2658HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ERBB2 cell lysate
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Cat.#:ERBB2-465HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ERBB2 cell lysate
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Cat.#:ERBB2-1727MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ERBB2 cell lysate
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Cat.#:ERBB2-2010RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ERBB2 cell lysate
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Cat.#:ERBB2-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ERBB2 cell lysate
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Cat.#:ERBB2-2008RCLTag:
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus ERBB2 cell lysate
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Involved Pathway

ERBB2 involved in several pathways and played different roles in them. We selected most pathways ERBB2 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
MAP2K2A; EGFRA; PTK2; PIK3CD; GSK3AA; GAB1; NRG2B; GRB2B; PLCG1; PAK1
Calcium signaling pathway
ADCY1A; PLN; PPP3CA; CACNA1H; CACNA1DA; ADRA1BB; TACR1; GNA15.4; RYR1; ADRB1
HIF- signaling pathway
ERBB2; PRKCA; MAP2K1; ARNT; IFNGR1; LDHA; MKNK1; ANGPT1; RPS6KB1; PDHA1
Focal adhesion
PIK3CB; IGF1; AKT2; ROCK2; CCND2A; PDGFA; CAV3; FYNA; ELK1; PPP1R12C
Adherens junction
TCF7; TCF7L1A; SMAD3; ACTN4; FARP2; PTPRF; PTBP3; FGFR1; VCLA; INSRA
Pathways in cancer
ITGA6; PRKCA; PDGFRB; FGF11; APPL1; GLI3; ZBTB16; RAC2; PTGS2; PGF
Proteoglycans in cancer
PRKCB; PTPN11; CAV2; IGF1; ESR1; SDC1; HCLS1; Fasl; TRP53; WNT2B
MicroRNAs in cancer
TP53; RPS6KA5; TNC; SOCS1; TP63; ITGA5; HMGA2; MAPK7; PDGFA; FZD3
Pancreatic cancer
MAPK1; ARHGEF6; PIK3CD; PLD1; RELA; TGFB3; AKT2; TGFB2; MAP2K1; RALBP1
Endometrial cancer
FOXO3; AKT1; HRAS; AXIN1; GRB2; PIK3CB; CTNNA2; APC; PIK3R1; TCF7L2
Prostate cancer
NRAS; FOXA1; GSTP1; SRD5A2; MAPK1; IKBKB; NKX3; CPN1; ACTL6B; SMARCC2
Bladder cancer
MAPK3; E2F3; VEGFA; ARAF; FGFR3; NRAS; MYC; BRAF; MDM2; TRP53
Non-small cell lung cancer
MAP2K1; FOXO3; PLCG2; RXRG; PRKCG; RASSF5; PLCG1; KRAS; PIK3CG; TRP53
Central carbon metabolism in cancer
PKM; MAPK3; PIK3CG; G6PD; FLT3; MAPK1; MTOR; G6PDX; PIK3CB; GLS

Protein Function

ERBB2 has several biochemical functions, for example, ATP binding, ErbB-3 class receptor binding, Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERBB2 itself. We selected most functions ERBB2 had, and list some proteins which have the same functions with ERBB2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NLK2; NWD1; MTPAP; MCM4; TESK1; VARS2; LARS; PEX6; PKDCC; PFKFB2A
Function ErbB-3 class receptor binding
Related Protein CDK5; NRG1; PIK3R1; ERBB2
Function Hsp90 protein binding
Related Protein PACRG; HDAC6; ERN1; NPAS2; AHR; FKBP6; UNC45A; PPEF2; TELO2; CHORDC1
Function RNA polymerase I core binding
Related Protein ERBB2
Function glycoprotein binding
Related Protein Itgam&Itgb2; SDC1; CSNK1D; CNTN2; VWF; LACRT; SERPINA1E; SHB; VIM; LDLR
Function contributes_to growth factor binding
Related Protein TGFBR1; ERBB2; IL6ST; ACVR1B
Function identical protein binding
Related Protein CLDN8; FHIT; BAG2; GCC2; CAV1; SNCAIP; ZDHHC17; DYNLT1C; RAD51; LYZ2
Function protein C-terminus binding
Related Protein SREBF2; HPCAL4; PROP1; AGO2; TJP2; CAV3; ERCC6; TOP2A; HAND2; KCNJ11
Function protein binding
Related Protein CSRNP1; TP53; DNAJA4; DAP3; GINS4; FGF19; FAM20A; INO80E; TAGLN2; POLH
Function protein dimerization activity
Related Protein MEF2AA; FBXW11B; STK4; STRA8; ASCL1B; NCOA2; ASCL2; NHLH2; POU2F3; MEF2D
Function protein heterodimerization activity
Related Protein PIK3R2; USF2; ADORA2A; FZD1; VAPB; BCL2L2; HEYL; PRPH; RRAGC; SOX32
Function protein phosphatase binding
Related Protein AP3B1; VCAN; CSK; CDKN1B; PPP1R3G; PPARG; ERBB2; SHOC2; KCNN4; VCP
Function protein tyrosine kinase activity
Related Protein PTK6B; ERBB3A; TTN; JAK3; IGF1RA; PTK2B; MET; TNK2; ABL1; EPHA2A
Function receptor signaling protein tyrosine kinase activity
Related Protein ERBB3B; SYK; ERBB2; LYN; INSR; KIT; EGFRA; ERBB4; KITB; KITA
Function transmembrane receptor protein tyrosine kinase activity
Related Protein EGFRA; TIE1; INSRR; ROS1; EPHA2; EPHA4A; CADM2B; AXL; IGF1RB; KDRL
Function transmembrane signaling receptor activity
Related Protein CD79A; GIPR; ICAM1; LILRA1; GPR182; OR6K3; LGR6; TLR18; NCR2; CLEC2D
Function ubiquitin protein ligase binding
Related Protein HSPA1A; TNFRSF1B; DBT; AMBRA1; AXIN1; AICDA; MUL1; CD40; KCNH2; PA2G4

Interacting Protein

ERBB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERBB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERBB2.
ERBB3