flt3lg
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  • Official Full Name
  • Fms-related tyrosine kinase 3 ligand
  • Background
  • Flt-3 ligand (FL) is a recently identified hematopoietic cytokine whose activities are mediated by binding to the transmembrane glycoprotein Flt-3. Flt-3 was first discovered as a member of the class III subfamily of receptor tyrosine kinases (RTK) whose expression among hematopoietic cells was found to be restricted to highly enriched stem/progenitor cell populations. Additional class III RTKs include the receptors from SCF, M-CSF and PDGF. Not surprisingly, Flt-3 ligand is also structurally related to M-CSF and SCF. All three cytokines have been shown to exist both as type I transmembrane proteins and as soluble proteins. The predominant human FL isoform is a transmembrane protein that can undergo proteolytic cleavage to generate a soluble form of the protein. An alternatively-spliced FL mRNA, encoding a soluble form of the human FL, has also been identified. FL is widely expressed in various human and mouse tissues. At the amino acid sequence level, human and mouse FL are approximately 72% identical and the two proteins exhibit cross-species activity. FL has been shown to synergize with a wide variety of hematopoietic cytokines to stimulate the growth and differentiation of early hematopoietic progenitors.
  • Synonyms
  • Flt 3 ligand; Flt 3L; Flt3 L; FLT3 LG; Flt3 ligand; Flt3L; FLT3L_HUMAN; Flt3lg; Fms related tyrosine kinase 3 ligand; Fms-related tyrosine kinase 3 ligand; SL cytokine; Flt3lg
Cat.#:FLT3LG-366HTag:
Source (Host):Human CellsSpecies:Human
Product nameRecombinant Human FLT3 Ligand Protein
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Cat.#:FLT3LG-312HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT3LG Protein (Thr 27 - Pro 185), His-tagged
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Cat.#:FLT3LG-973RTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat FLT3LG Protein (Thr28-Gln189), His-tagged
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Cat.#:FLT3LG-2339HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT3LG Protein, MYC/DDK-tagged
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Cat.#:FLT3LG-4374HTag:His
Source (Host):Barley grainSpecies:Human
Product nameRecombinant Human FLT3LG Protein, His-tagged
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Cat.#:FLT3LG-4375HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FLT3LG Protein, GST-tagged
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Cat.#:FLT3LG-5262HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FLT3LG Protein, GST-tagged
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Cat.#:FLT3LG-5423HTag:His
Source (Host):Hordeum vulgare (barley grain). Barley grain exhibits up to 50 times less protease activity than E. coli or mammalian cells. Barley seed is void of any human or animal viral contaminants that could jeopardize cell culture.Species:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 3 Ligand, His-tagged
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Cat.#:FLT3LG-1235RTag:
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey FLT3LG Protein
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Cat.#:FLT3LG-02HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 3 Ligand
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Cat.#:FLT3LG-1235HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLT3LG
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Cat.#:FLT3LG-151HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human FLT3LG
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Cat.#:FLT3LG-152HTag:
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human FLT3LG
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Cat.#:FLT3LG-154HTag:
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human FLT3LG
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Cat.#:FLT3LG-155HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FLT3LG protein
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Cat.#:FLT3LG-246HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FLT3LG, Fc-tagged
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Cat.#:FLT3LG-254HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT3LG, StrepII-tagged
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Cat.#:FLT3LG-25HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human FLT3L protein
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Cat.#:FLT3LG-275HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 3 Ligand, MIgG2a Fc-tagged
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Cat.#:FLT3LG-276HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 3 Ligand, HIgG1 Fc-tagged, mutant
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Cat.#:FLT3LG-278HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 3 Ligand, HIgG1 Fc-tagged
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Cat.#:FLT3LG-28341THTag:His
Source (Host):Species:Human
Product nameRecombinant Human FLT3LG, His-tagged
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Cat.#:FLT3LG-28905THTag:
Source (Host):Species:Human
Product nameRecombinant Human FLT3LG
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Cat.#:FLT3LG-8532HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FLT3LG, His tagged
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Cat.#:FLT3LG-8901HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human FLT3LG
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Cat.#:FLT3LG-939HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human FLT3LG Protein, His-tagged
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Cat.#:FLT3LG-636FTag:His
Source (Host):NSO cellsSpecies:Feline
Product nameRecombinant Feline FLT3LG, His-tagged
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Cat.#:FLT3LG-935HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 3 Lligand
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Cat.#:FLT3LG-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FLT3LG cell lysate
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Cat.#:FLT3LG-105HGTag:
Source (Host):Insect cellSpecies:Human
Product nameGMP Recombinant Human FLT3LG Protein
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Cat.#:FLT3LG-4348HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human FLT3LG protein
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Involved Pathway

FLT3LG involved in several pathways and played different roles in them. We selected most pathways FLT3LG participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT3LG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCR9A; CCR6A; Il4ra; IL5; PDGFB; LEPB; IL2RGB; IL18RAP; GM2002; PRLRA
Hematopoietic cell lineage
ITGA1; Itgam&Itgb2; GM2002; CD1E, B2M; CR1; CD4; Cd24a; EPO; ITGAM; GP1BB
Pathways in cancer
PRKACB; LAMB3; STK36; MSH3; ARHGEF1; PIK3R1; NFKB2; NKX3-1; TRAF5; STAT5B

Protein Function

FLT3LG has several biochemical functions, for example, cytokine activity, protein homodimerization activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT3LG itself. We selected most functions FLT3LG had, and list some proteins which have the same functions with FLT3LG. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein NDR1; TNFB; IL1F10; INHBB; GM13289; IFNG; Fasl; HMGB1B; INHBE; BMP8B
Function protein homodimerization activity
Related Protein RASGRP1; TERF2; PTPRO; DPY30; MTHFD1L; PEX11B; GRM6; DSCAML1; HSF2; PDK2
Function receptor binding
Related Protein ASIP; PAOX; FZD8; TNFSF15; BMP2; FGF20B; GNB2L1; KNG1; PVRL3; CNPY3
Function receptor tyrosine kinase binding
Related Protein TP53; SOCS5; PCNA; CPNE3; ARHGEF16; PTPN14; PTPN2; LRP4; PTPN1; ANGPT2

Interacting Protein

FLT3LG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT3LG here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT3LG.
KITLG; PFN2