il2ra
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  • Official Full Name
  • interleukin 2 receptor, alpha
  • Background
  • Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  • Synonyms
  • Interleukin 2 receptor alpha chain; CD 25; CD25; CD25 antigen; IDDM10; IL 2 RA; IL 2 receptor alpha subunit; IL 2R; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2 RA; IL2R; IL2RA_HUMAN; IL2RAC; Interleukin 2 Receptor Alpha; Interleukin 2 receptor; Interleukin-2 receptor subunit alpha; Ly43; p55; T Cell Growth Factor Receptor; TAC; TAC Antigen; TCGFR; interleukin 2 receptor, alpha
Cat.#:IL2RA-170HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA protein, Fc-tagged, APC labeled
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Cat.#:IL2RA-170HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA protein, Fc-tagged, R-PE labeled
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Cat.#:IL2RA-2025HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA Protein, His-tagged
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Cat.#:IL2RA-636HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA protein, Fc-tagged, APC labeled
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Cat.#:IL2RA-636HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA protein, Fc-tagged, R-PE labeled
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Cat.#:IL2RA-942RTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat IL2RA Protein (Met1-Gln235), His-tagged
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Cat.#:IL2RA-5197HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2RA Protein
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Cat.#:IL2RA-5198HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA Protein
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Cat.#:IL2RA-5199HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL2RA Protein
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Cat.#:Il2ra-474RTag:N/A
Source (Host):CHOSpecies:Rat
Product nameRecombinant Rat Interleukin 2 Receptor, Alpha
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Cat.#:IL2RA-170HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA, Fc-tagged
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Cat.#:IL2RA-4951HTag:N/A
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human IL2RA
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Cat.#:IL2RA-636HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA, Fc tagged
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Cat.#:IL2RA-637HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA, His tagged
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Cat.#:IL2RA-948HTag:
Source (Host):Hi-5 insect cellsSpecies:Human
Product nameRecombinant Human IL2RA Protein
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Cat.#:IL2RA-99HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2RA protein, His-tagged
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Cat.#:Il2ra-1865MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il2ra protein, His & S-tagged
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Cat.#:Il2ra-4021MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il2ra, His tagged
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Cat.#:Il2ra-5654MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Interleukin 2 Receptor, Alpha Chain, His-tagged
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Cat.#:Il2ra-1867RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il2ra protein, His-tagged
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Cat.#:Il2ra-1868RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il2ra protein, His & S-tagged
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Cat.#:IL2RA-3043RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL2RA Protein
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Cat.#:IL2RA-133CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL2RA, Fc tagged
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Cat.#:IL2RA-134CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL2RA, His tagged
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Cat.#:IL2RA-135CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL2RA, LEVLFQ tagged
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Cat.#:IL2RA-618CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL2RA Protein, His-tagged
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Cat.#:IL2RA-2247RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL2RA Protein, His-tagged
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Cat.#:IL2RA-460CTag:His
Source (Host):NSO cellsSpecies:Canine
Product nameRecombinant Canine IL2RA, His-tagged
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Cat.#:IL2RA-6165CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL2RA
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Cat.#:IL2RA-1864CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL2RA protein, His & T7-tagged
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Cat.#:IL2RA-1866PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL2RA protein, His & T7-tagged
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Cat.#:IL2RA-1237HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Interleukin 2 Receptor, Alpha
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Cat.#:IL2RA-1325HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 2 Receptor, Alpha, GST-tagged
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Cat.#:IL2RA-2907HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2RA cell lysate
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Cat.#:IL2RA-2024MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL2RA cell lysate
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Cat.#:IL2RA-1015CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL2RA cell lysate
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Cat.#:CDA085PTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD-25
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Cat.#:CBCRY33Tag:
Source (Host):E. coliSpecies:
Product nameInterleukin-2 with its alpha Receptor
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Involved Pathway

IL2RA involved in several pathways and played different roles in them. We selected most pathways IL2RA participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PRLRA; IFNL3; IL21R; CXCL16; ACVR2B; GM13306; BMPR1AA; LIFR; CCL4L2; FLT4
Endocytosis
CBL; ZFYVE16; ARF1L; TGFBR1; RAB4A; VPS37B; ADRB3A; SMURF2; ARAP1; PLD2
PIK-Akt signaling pathway
ITGB6; LAMA5; IL6; PPP2R5E; FGF1; KLK1B4; LPAR5; PIK3CA; RAF1; G6PC3
Jak-STAT signaling pathway
Il4ra; IFNA4; OSM; IL4R; IFNA8; IL10RA; PIK3CA; PIK3CB; IL13RA2; STAT4
Hematopoietic cell lineage
CD1A; CD8B1; Itga10&Itgb1; CD1D; IL5RA; HLA-DRA; EPO; IL3RA; IL11RA; CD3E
Measles
IFNA2; CD3E; CD3D; IRF3; IFNGR1; BBC3; CBLB; EIF3H; MSN; PIK3CG; IFNA16
HTLV-I infection
HLA-DOA; PDGFRA; MYBL2; NFATC2; HLA-DRB1; SFPI1; TSPO; MAP3K14; PIK3CD; ELK4

Protein Function

IL2RA has several biochemical functions, for example, drug binding, interleukin-2 binding, interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RA itself. We selected most functions IL2RA had, and list some proteins which have the same functions with IL2RA. You can find most of the proteins on our site.
Function
Related Protein
Function drug binding
Related Protein HTR2B; TLR7; NAMPT; FOLR2; FOLR1; PNP; ACE; CNR1; MT3; GRIK1
Function interleukin-2 binding
Related Protein IL2RG; IL2RB; IL2RA
Function interleukin-2 receptor activity
Related Protein IL2RA; IL2RB

Interacting Protein

IL2RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RA.
PASK

IL2RA Related Articles

Oliveira, PRS; Dessein, H; et al. IL2RA Genetic Variants Reduce IL-2-Dependent Responses and Aggravate Human Cutaneous Leishmaniasis. JOURNAL OF IMMUNOLOGY 194:2664-2672(2015).
Savilova, AM; Chulkina, MM; et al. Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 158:561-565(2015).

IL2RA Related Gene Family

IL