IL21 Protein, interleukin 21


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Official Full Name interleukin 21
Background A novel cytokine related to IL2 and IL15 was recently identified and designated IL21. IL21 has been found to be a powerful growth factor for naive B cells. The receptor for IL21 (IL21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL21 signaling. Both IL21R and the gc are necessary for the IL21 function. IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Synonyms IL21; interleukin 21; interleukin-21; IL-21; Il21
    • Species :
    • Bovine
    • Canine
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Salmon
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Yeast
    • Tag :
    • Avi
    • Fc
    • His
    • GST
    • human
    • IgG1
    • Met
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Il21-153M Recombinant Mouse Il21 Protein E.coli
    Human IL21-16H Recombinant Human IL21 Protein, Fc-Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human IL21-298H Recombinant Human IL21 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL21-735H Recombinant Human IL21 Protein E.coli N/A
    Human Il21-001H Recombinant Human Il21, HIgG1 Fc-tagged, mutant CHO Fc
    Human Il21-002H Recombinant Human Il21, MIgG2a Fc-tagged CHO Fc
    Human Il21-003H Recombinant Human Il21, HIgG1 Fc-tagged CHO Fc
    Human IL21-004H Recombinant Human IL21, MIgG2a Fc-tagged CHO Fc
    Human IL21-006H Recombinant Human IL21, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL21-15H Recombinant Human IL21, His-tagged Human Cell His
    Human IL21-1804H Recombinant Human IL21 protein, His & GST-tagged E.coli His/GST
    Human IL21-292H Recombinant Human IL21, StrepII-tagged Human Cell Strep II
    Human IL21-337H Recombinant Human IL21, Fc-tagged CHO Fc
    Human IL21-371H Recombinant Human IL21 protein E.coli N/A
    Human IL21-4334HG GMP Recombinant Human IL21 protein E.coli N/A
    Human IL21-501H Recombinant Human IL21 Protein E.coli N/A
    Human IL21-652H Recombinant Human IL21 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL21-864H Recombinant Human IL21 Protein HEK293 N/A
    Human IL21-866H Recombinant Human IL21 Protein E.coli N/A
    Mouse IL21-021M Recombinant Mouse IL21, MIgG2a Fc-tagged CHO Fc
    Mouse IL21-022M Recombinant Mouse IL21, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse Il21-169M Recombinant Mouse Il21 protein E.coli N/A
    Mouse Il21-1805M Recombinant Mouse Il21 protein, His & GST-tagged E.coli His/GST
    Mouse Il21-338M Recombinant Mouse Il21, Fc-tagged CHO Fc
    Mouse Il21-844M Recombinant Mouse Il21 Protein E.coli N/A
    Rat IL21-001RCL Recombinant Rat IL21 cell lysate Insect Cell N/A
    Rat IL21-3039R Recombinant Rat IL21 Protein Mammalian Cell His
    Rat IL21-378R Recombinant Rat Il21, His tagged Insect Cell Fc
    Rat Il21-581R Recombinant Rat Il21 protein E.coli N/A
    Rhesus Macaque IL21-2244R Recombinant Rhesus monkey IL21 Protein, His-tagged Mammalian Cell His
    Canine IL21-630C Recombinant Canine IL21, Met-tagged E.coli Met
    Bovine IL21-238B Recombinant Bovine Interleukin 21 Yeast N/A
    Chicken IL21-2205C Recombinant Chicken IL21 Mammalian Cell His
    Rabbit IL21-4336R Recombinant Rabbit IL21 Protein Yeast N/A
    Zebrafish IL21-6949Z Recombinant Zebrafish IL21 Mammalian Cell His
    Pig IL21-103S Recombinant Swine IL21 Yeast N/A
    Salmon il21-4335S Recombinant Salmon il21 Protein Yeast N/A

    IL21 involved in several pathways and played different roles in them. We selected most pathways IL21 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TNFSF8; IL6ST; ACVR1B; IL28RA; CSF3; CSF2RA; GDF5; TNFSF10; OSMR; CSF2RB
    Jak-STAT signaling pathway IL15; IFNA5; IFNA6; IFNA16; IFNW1; CCND3; LEP; CSH; IFNA17; IFNA8
    Inflammatory bowel disease (IBD) FOXP3; GATA3; IL6; IFNG; STAT3; IL21R; RORC; IL1B; HLA-DPA1; MAF

    IL21 has several biochemical functions, for example, cytokine activity, cytokine receptor binding, interleukin-2 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL21 itself. We selected most functions IL21 had, and list some proteins which have the same functions with IL21. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity NRG1; IL17A/F1; IL1RN; MSTN; IFNA10; Il2; LFT1; IFNA6; IL28A; GREM2
    cytokine receptor binding IFNPHI1; IL15; IL17F; IL21; IFNT2; IL17C; IL17B; IFNA14; IFNA12; IFNPHI3
    interleukin-2 receptor binding ECM1; IL21; TIMM50; Il2; GATA3

    IL21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL21 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL21.


    Kenefeck, R; Wang, CJ; et al. Follicular helper T cell signature in type 1 diabetes. JOURNAL OF CLINICAL INVESTIGATION 125:292-303(2015).
    Balabko, L; Andreev, K; et al. Increased expression of the Th17-IL-6R/pSTAT3/BATF/Ror gamma T-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung. SCIENTIFIC REPORTS 4:-(2014).

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