IL21
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Official Full Name
interleukin 21
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Overview
A novel cytokine related to IL2 and IL15 was recently identified and designated IL21. IL21 has been found to be a powerful growth factor for naive B cells. The receptor for IL21 (IL21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL21 signaling. Both IL21R and the gc are necessary for the IL21 function. IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations. -
Synonyms
IL21; interleukin 21; interleukin-21; IL-21; Il21;
- Recombinant Proteins
- GMP Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Canine
- Chicken
- Cynomolgus
- Cynomolgus Monkey
- Dog
- Human
- Mouse
- Pig
- Rabbit
- Rat
- Rhesus Macaque
- Rhesus monkey
- Salmon
- Zebrafish
- CHO
- CHO-K1
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Cell
- Human cells
- Insect Cell
- Insect Cells
- Mamanlian cells
- Mammalian Cell
- Yeast
- Avi|Fc
- C
- His
- Fc
- Avi
- Flag
- His (Fc)
- His(C
- ter)
- His|GST
- human|IgG1|Fc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- hFc
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- IL21 Related Articles
- IL21 Related Research Area
IL21 involved in several pathways and played different roles in them. We selected most pathways IL21 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | XCL1;CCL4;IFNE;CCR6;MPL;TNFSF13;CCR1L1;PDGFA;IL12A |
Jak-STAT signaling pathway | IL12RB1;Il2;IL12B;GM13305;IL6R;IL2RG;IL20RA;STAT1A;CNTF |
Inflammatory bowel disease (IBD) | IL18R1;HLA-DRB3;IL1A;H2-AA;Il23a; Il12b;HLA-DMB;SMAD2;IL21R;TNF |
IL21 has several biochemical functions, for example, cytokine activity, cytokine receptor binding, interleukin-2 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL21 itself. We selected most functions IL21 had, and list some proteins which have the same functions with IL21. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | IL17A/F3;IL32;GM13279;NAMPT;IFNE;IL26;TNFSF9;Cxcl15;BMP2 |
cytokine receptor binding | IL17C;IL15L;IFNPHI3;IL15;IFNA13;IFNA3;IFNA8;IL17A/F1;IFNPHI4 |
interleukin-2 receptor binding | Il2;TIMM50;ECM1;IL21;GATA3 |
IL21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL21 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL21.
PARP2; DGKA
- Q&As
- Reviews
Q&As (5)
Ask a questionIL21 has demonstrated efficacy in preclinical and clinical studies for various cancers, including melanoma, renal cell carcinoma, and lymphoma.
Common side effects may include fatigue, fever, and flu-like symptoms. However, the severity and type of side effects can vary among individuals.
IL21 is often investigated in combination with other cancer therapies to enhance its effectiveness, and it has shown promise in combination treatments.
Yes, several clinical trials are investigating the efficacy and safety of IL21 in autoimmune diseases, such as rheumatoid arthritis and lupus.
IL21 promotes the differentiation and survival of memory T cells, contributing to the long-term immune response against pathogens.
Customer Reviews (3)
Write a reviewWith the IL21 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.
I am confident that incorporating the IL21 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes
Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.
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