il21
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  • Official Full Name
  • interleukin 21
  • Background
  • A novel cytokine related to IL2 and IL15 was recently identified and designated IL21. IL21 has been found to be a powerful growth factor for naive B cells. The receptor for IL21 (IL21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL21 signaling. Both IL21R and the gc are necessary for the IL21 function. IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations.
  • Synonyms
  • IL21; interleukin 21; interleukin-21; IL-21; Il21
Cat.#:IL21-16HTag:Fc-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL21 Protein, Fc-Avi-tagged, Biotinylated
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Cat.#:IL21-735HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IL21 Protein
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Cat.#:IL21-4336RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit IL21 Protein
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Cat.#:il21-4335STag:
Source (Host):YeastSpecies:Salmon
Product nameRecombinant Salmon il21 Protein
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Cat.#:Il21-001HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il21, HIgG1 Fc-tagged, mutant
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Cat.#:Il21-002HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il21, MIgG2a Fc-tagged
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Cat.#:Il21-003HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il21, HIgG1 Fc-tagged
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Cat.#:IL21-004HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL21, MIgG2a Fc-tagged
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Cat.#:IL21-006HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL21, HIgG1 Fc-tagged, mutant
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Cat.#:IL21-15HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL21, His-tagged
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Cat.#:IL21-1804HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL21 protein, His & GST-tagged
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Cat.#:IL21-292HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL21, StrepII-tagged
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Cat.#:IL21-337HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL21, Fc-tagged
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Cat.#:IL21-371HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL21, None tagged
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Cat.#:IL21-501HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL21 Protein
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Cat.#:IL21-652HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL21 protein, MYC/DDK-tagged
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Cat.#:IL21-864HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human IL21 Protein
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Cat.#:IL21-866HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL21 Protein
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Cat.#:IL21-021MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL21, MIgG2a Fc-tagged
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Cat.#:IL21-022MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL21, MIgG2a Fc-tagged, mutant
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Cat.#:Il21-1805MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il21 protein, His & GST-tagged
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Cat.#:Il21-338MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il21, Fc-tagged
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Cat.#:Il21-844MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il21 Protein
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Cat.#:IL21-3039RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL21 Protein
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Cat.#:IL21-378RTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat Il21, His tagged
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Cat.#:Il21-581RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il21
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Cat.#:IL21-2244RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL21 Protein, His-tagged
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Cat.#:IL21-630CTag:Met
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine IL21, Met-tagged
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Cat.#:IL21-2205CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL21
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Cat.#:IL21-6949ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL21
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Cat.#:IL21-103STag:
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine IL21
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Cat.#:Il21-169MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 21
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Cat.#:IL21-238BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Interleukin 21
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Cat.#:IL21-001RCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Rat IL21 cell lysate
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Cat.#:IL21-4334HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL21 protein
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Involved Pathway

IL21 involved in several pathways and played different roles in them. We selected most pathways IL21 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCR8; IL3RA; M17; VEGFA; IL2RGB; CCR6A; CCL4L2; IFNG; CCL6; FIGF
Jak-STAT signaling pathway
LIFRA; IL22RA1; AKT2; CCND3; PTPN6; AOX4; FHL1A; GH2; PIK3R1; IFNG
Inflammatory bowel disease (IBD)
IFNG; Il2; TLR5; IFNGR2; NFATC1; IL23R; TGFB3; IL4; IL17A; RORA

Protein Function

IL21 has several biochemical functions, for example, cytokine activity, cytokine receptor binding, interleukin-2 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL21 itself. We selected most functions IL21 had, and list some proteins which have the same functions with IL21. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein CSF1B; IL33; TNFB; IL36RN; IL1A; TNFSF12; GDF3; Ifnl2; IFNA5; IFN-a
Function cytokine receptor binding
Related Protein IFNPHI2; IFNW1; IFNA21; IL17C; IL17A/F2; IL17A/F3; MIF; IFNPHI1; IL15; IFNA5
Function interleukin-2 receptor binding
Related Protein ECM1; TIMM50; GATA3; IL21; Il2

Interacting Protein

IL21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL21 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL21.
PARP2; DGKA

IL21 Related Articles

Kenefeck, R; Wang, CJ; et al. Follicular helper T cell signature in type 1 diabetes. JOURNAL OF CLINICAL INVESTIGATION 125:292-303(2015).
Balabko, L; Andreev, K; et al. Increased expression of the Th17-IL-6R/pSTAT3/BATF/Ror gamma T-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung. SCIENTIFIC REPORTS 4:-(2014).