il22
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  • Official Full Name
  • interleukin 22
  • Background
  • Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.
  • Synonyms
  • IL22; interleukin 22; TIFa; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; MGC79382; MGC79384; TIFIL-23; IL-10-related T-cell-derived inducible factor
Cat.#:IL22-002HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IL22 Protein, His-tagged
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Cat.#:IL22-449HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL22 Protein, His-tagged
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Cat.#:IL22-4375CTag:
Source (Host):YeastSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey IL22 Protein
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Cat.#:IL22-4348STag:
Source (Host):YeastSpecies:Sheep
Product nameRecombinant Sheep IL22 Protein
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Cat.#:IL22-4349CTag:
Source (Host):YeastSpecies:Caprine
Product nameRecombinant Caprine IL22 Protein
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Cat.#:IL22-135HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL22 protein
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Cat.#:IL22-14185HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL22, GST-tagged
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Cat.#:IL22-15HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL22 protein, His-tagged
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Cat.#:IL22-215HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL22, StrepII-tagged
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Cat.#:IL22-342HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL22, Fc-tagged
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Cat.#:IL22-461HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL22
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Cat.#:IL22-561HTag:Fc
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human IL22, MIgG2a Fc-tagged
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Cat.#:IL22-562HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL22, HIgG1 Fc-tagged, mutant
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Cat.#:IL22-563HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL22, HIgG1 Fc-tagged
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Cat.#:Il22-344MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il22, His-tagged
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Cat.#:Il22-345MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il22, Fc-tagged
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Cat.#:Il22-549MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il22
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Cat.#:IL22-600MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL22, MIgG2a Fc-tagged, mutant
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Cat.#:IL22-601MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Interleukin 22, MIgG2a Fc-tagged
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Cat.#:IL22-90MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IL-22
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Cat.#:Il22-001RTag:Fc
Source (Host):CHOSpecies:Rat
Product nameRecombinant Rat Il22, HIgG1 Fc-tagged
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Cat.#:Il22-582RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il22
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Cat.#:IL22-2245RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL22 Protein, His-tagged
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Cat.#:IL22-4423CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL22
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Cat.#:IL22-2926ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL22
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Cat.#:IL22-555HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 22
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Cat.#:IL22-637HTag:HQ
Source (Host):Hordeum vulgare (barley grain)Species:Human
Product nameRecombinant Human Interleukin 22, HQ-tagged
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Cat.#:Il22-439MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 22, PEG-tagged
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Cat.#:Il22-639MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 22
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Cat.#:Il22-28MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin-22
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Cat.#:IL22-5232HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IL22 293 Cell Lysate
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Cat.#:IL22-4335HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL22 protein
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Involved Pathway

IL22 involved in several pathways and played different roles in them. We selected most pathways IL22 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL1R2; IL12B; HGF; TNFSF11; IL7R; TNFRSF14; IL19; CSF1R; RELT; CCR1
Jak-STAT signaling pathway
PIAS4B; SOS1; LEPB; IL4; SOCS4; STAT4; IL3; IL13RA2; IL2RGA; Ifna15
Inflammatory bowel disease (IBD)
IL23; TGFB3; HLA-DRA; NFKB1; IL12B; IL4R; HLA-DOB; IL18R1; MAF; HLA-DQA2

Protein Function

IL22 has several biochemical functions, for example, cytokine activity, interleukin-22 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22 itself. We selected most functions IL22 had, and list some proteins which have the same functions with IL22. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein LFT2; IFNA2; IFNA3; MIF; OSTN; NAMPT; GM13278; NDR1; BMP10; TXLNA
Function interleukin-22 receptor binding
Related Protein IL22; IL20

Interacting Protein

IL22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22.
IL22RA1; IL22RA2

IL22 Related Articles

Akha, AAS; McDermott, AJ; et al. Interleukin-22 and CD160 play additive roles in the host mucosal response to Clostridium difficile infection in mice. IMMUNOLOGY 144:587-597(2015).
Ali, IM; Evehe, MSB; et al. Host candidate gene polymorphisms and associated clearance of P. falciparum amodiaquine and fansidar resistance mutants in children less than 5 years in Cameroon. PATHOGENS AND GLOBAL HEALTH 108:323-333(2014).

IL22 Related Gene Family

IL