cd40
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  • Official Full Name
  • CD40 antigen
  • Background
  • CD40 is a cell surface receptor that is expressed on the surface of all mature B cells, most mature B -cell malignancies, and some early B-cell acute lymphocytic leukemias, but is not expressed on plasma cells. The CD40 gene is localized to the long arm of chromosome 20, bands q12-q13.2. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
  • Synonyms
  • CD40; CD40 molecule, TNF receptor superfamily member 5; p50; Bp50; CDW40; TNFRSF5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CD_antigen=CD40; CD40 antigen; Dacetuzumab; 880486-59-9; Teneliximab; 299423-37-3
Cat.#:Cd40-87MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd40 protein, His-tagged
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Cat.#:CD40-1087HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40 Protein (Met1-Arg193), His-tagged, Biotinylated
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Cat.#:CD40-1088MTag:HlgG1 Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD40 Protein (Met1-Arg193), HlgG1 Fc-tagged
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Cat.#:CD40-108HATag:Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD40 protein, Fc-tagged, APC labeled
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Cat.#:CD40-108HPTag:Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD40 protein, Fc-tagged, R-PE labeled
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Cat.#:Cd40-325MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD40 Protein, Fc-tagged
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Cat.#:CD40-371HTag:Fc/Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40 Protein, Fc & Avi-tagged, Biotinylated
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Cat.#:CD40-388RTag:Fc
Source (Host):HEK293Species:Rhesus Monkey
Product nameRecombinant Rhesus Monkey CD40 Protein, Fc-tagged
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Cat.#:CD40-389HTag:MIgG2a Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40 Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:CD40-816MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse CD40 Protein (Val24-Arg193), His-tagged
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Cat.#:CD40-928CTag:His
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine CD40 Protein (Glu21-Ala194), His-tagged
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Cat.#:CD40-0810HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD40 Protein
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Cat.#:CD40-0811HTag:His-Flag-StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD40 Protein, His-Flag-StrepII-Tagged
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Cat.#:CD40-0812HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD40 Protein, GST-Tagged
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Cat.#:CD40-493HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40, Fc Chimera
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Cat.#:Cd40-1715MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse CD40 Antigen, Fc-His
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Cat.#:CD40-017HTag:Fc
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CD40 Protein, Fc-tagged
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Cat.#:CD40-105HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD40, MIgG2a Fc-tagged
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Cat.#:CD40-106HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD40, HIgG1 Fc-tagged
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Cat.#:CD40-107HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD40 Protein, His-tagged
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Cat.#:CD40-108HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD40 Protein, Fc-tagged
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Cat.#:CD40-174HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40, Fc-His tagged
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Cat.#:CD40-202HTag:His/Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40 protein, His/Fc-tagged, Biotinylated
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Cat.#:CD40-2221HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40, His tagged
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Cat.#:CD40-2222HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40 Protein, His & Avi-tagged, Biotinylated
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Cat.#:CD40-27810THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human CD40, Fc-tagged
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Cat.#:CD40-369HTag:Hi & Fc & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40 protein, Hi & Fc & Avi-tagged, Biotinylated
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Cat.#:CD40-4980HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40 Molecule, TNF Receptor Superfamily Member 5
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Cat.#:CD40-5119HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40, His-tagged
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Cat.#:CD40-518HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD40 molecule, TNF receptor superfamily member 5, His-tagged
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Cat.#:CD40-577HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD40, Fc-tagged, Biotinylated
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Cat.#:Cd40-4981MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse CD40 Antigen
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Cat.#:Cd40-6717MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd40 protein, His & T7-tagged
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Cat.#:Cd40-6892MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd40, Fc-His tagged
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Cat.#:Cd40-81MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Cd40 protein, His-tagged
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Cat.#:Cd40-86MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd40, His-tagged
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Cat.#:Cd40-6718RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd40 protein, His & T7-tagged
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Cat.#:Cd40-8726RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd40, Fc tagged
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Cat.#:Cd40-8727RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd40, His tagged
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Cat.#:CD40-23CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD40 Protein, His-tagged
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Cat.#:CD40-85CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD40 Protein, His-tagged
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Cat.#:CD40-8823CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD40, Fc tagged
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Cat.#:CD40-740RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD40 Protein, His-tagged
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Cat.#:CD40-741RTag:His
Source (Host):HEK293Species:Rhesus macaque
Product nameRecombinant Rhesus macaque CD40 Protein, His-tagged
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Cat.#:CD40-8824CTag:His
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus CD40 protein, His-tagged
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Cat.#:CD40-153CTag:FC/His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD40, LEVLFQ tagged
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Cat.#:CD40-165CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD40, His-tagged
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Cat.#:CD40-167CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD40, Fc tagged
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Cat.#:CD40-6231CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CD40
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Cat.#:CD40-7316ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CD40
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Cat.#:CD40-2617HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD40 cell lysate
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Cat.#:CD40-1831MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD40 cell lysate
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Cat.#:CD40-1262RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD40 cell lysate
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Cat.#:CD40-1254CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD40 cell lysate
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Cat.#:CD40-001CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD40 cell lysate
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Involved Pathway

CD40 involved in several pathways and played different roles in them. We selected most pathways CD40 participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD40 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
Kitl; CD27; BMPR1BB; GM13304; TGFB1A; CCL22; Ccl21a; KDR; FLT1; CCL28
NF-kappa B signaling pathway
BCL2; BIRC2; CD40; TNFRSF13C; PIDD1; TNFRSF11A; PLAU; IRAK1; CXCL12; TNFSF11
Cell adhesion molecules (CAMs)
CLDN3; LRRC4; CLDNF; CLDNH; NEO1; NFASC; CLDN14; NLGN2A; NRXN3; H2-AA
Toll-like receptor signaling pathway
MAPK8A; IFNA12; MAP2K3; NFKBIA; IFNAR2; IL12BA; AKT3A; CD86; MAP3K7; MAP2K7
Intestinal i
CXCL12A; MHC2A; CD80; HLA-DQB1; CD40LG; CXCR4A; CCR10; CCL27B; BLB2; HLA-DRB1
ne network for IgA production
BMA1; IL5; BMA2; PIGR; BLB2; ICOS; Icosl; CCL28; MAP3K14; TNFRSF13B
Malaria
CD40; CD40LG; PECAM1; KLRC4-KLRK1; IFNG; TLR4; ITGB2; IL18; ITGB2L; GYPC
Toxoplasmosis
HLA-DPA1; BIRC3; CYCS; HSPA1L; PDPK1; MAPK9; HLA-DRA; HSPA1B; TGFB1; ALOX5
HTLV-I infection
STAT5B; PPP3CC; TRP53INP1; H2-AB1; LTBR; XIAP; WNT2; WNT2B; DLG1; FZD3
Epstein-Barr virus infection
HDAC4; GSK3B; SND1; PSMD6; GTF2E1; MAPK12; HLA-DRB3; HSPA8; NFKB1; POLR3B
Transcriptional misregulation in cancer
ZEB1; WT1; PFTK1; MAF; PLAT; WHSC1; CLSTN2; Pdgfa&Pdgfb; MLL1; NGFR
Asthma
HLA-DRB1; IL9; H2-AA; HLA-DOB; HLA-DPA1; HLA-DMB; HLA-DOA; H2-AB1; HLA-DRA; CD40
Autoi
IFNA12; HLA-DMB; HLA-DQA2; HLA-DPA1; IFNA21; HLA-DRB1; HLA-DRA; IFNA13; FAS; H2-AB1
ne thyroid disease
IFNA21; H2-Q10; IFNA7; HLA-DRB4; HLA-DRB3; IFNA6; IFNA8; IFNA2; CD86; HLA-DQA1
Systemic lupus erythematosus
ELANE; HIST2H2BE; H2AFV; H2AFY2; HIST2H3C1; HIST1H2AP; HIST1H3I; HIST1H2BB; HIST1H4E; C9
Allograft rejection
HLA-DRB1; IL5; FAS; CD40; Il2; CD80; HLA-DQB1; Fasl; HLA-DOB; IL12A
Primary i
BTK; ZAP70; TNFRSF13B; ORAI1; TAP1; TAP2; CD19; RFX5; LCK; RAG1
nodeficiency
TAP2; ICOS; IL2RG; IGLL1; PTPRC; RFX5; CD8B; ZAP70; UNG; ORAI1
Viral myocarditis
CASP9; ITGB2; RAC1; HLA-E; HLA-DMA; CAV1; HLA-DPA1; H2-AB1; HLA-DRB1; CD40LG

Protein Function

CD40 has several biochemical functions, for example, antigen binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD40 itself. We selected most functions CD40 had, and list some proteins which have the same functions with CD40. You can find most of the proteins on our site.
Function
Related Protein
Function antigen binding
Related Protein IGLC2; SLAMF1; FCN3; LILRA2; IGJ; LILRA3; PPP2R1A; LAG3; LILRB4; TSPAN4
Function enzyme binding
Related Protein KDM4C; PHB; RAD9A; CYP3A4; HIST1H2AD; UGT1A6B; PTPLA; TSPYL1; SORT1; CSF3
Function protein binding
Related Protein C2orf63; FRMD5; ZDHHC17; Rhox5; PSMB3; MIIP; SH2B1; RPSA; MPHOSPH8; SERPINB3C
Function receptor activity
Related Protein NOTCH1; CLEC4E; ADIPOR1; CRTAM; ITGB4; NPC1; NLGN4Y; SLC40A1; CD86; GRIA2A
Function signal transducer activity
Related Protein TAAR12C; COPS2; MRGPRB8; HMOX1; MRGPRA8; IRS1; ADORA2AB; GNB2; SHISA5; TAAR15
Function tumor necrosis factor-activated receptor activity
Related Protein TNFRSF18; TNFRSF10C; TNFRSF21; NRADD; TNFRSF14; TNFRSF1A; TNFRSF25; CD40; EDA2R; TNFRSF4
Function ubiquitin protein ligase binding
Related Protein GABARAP; CBS; CDC34A; BRCA1; SMAD5; FLJ11011L; PCBP2; BAG5; RFFL; UBE2NA

Interacting Protein

CD40 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD40 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD40.
TRAF2; TRAF6; TRAF3; 21362046; SGK1; OGT; KATNA1; TXN; PCMT1; FBL; CALR

CD40 Related Articles

Chandraratne, S; von Bruehl, ML; et al. Critical Role of Platelet Glycoprotein Iba in Arterial Remodeling. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:589-597(2015).
Cozza, EM; Cooper, TK; et al. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:325-336(2015).

CD40 Related Gene Family

TNF