ctla4
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  • Official Full Name
  • Ctla4 cytotoxic T-lymphocyte-associated protein 4
  • Background
  • CD152 is a 33 kD member of the immunoglobulin superfamily also known as CTLA-4 or Ly-56. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cellmediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance, as well as the development of protective immunity and thymocyte regulation.
  • Synonyms
  • CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Ipilimumab; Yervoy; 477202-00-9; Ticilimumab (= tremelimumab); 745013-59-6
Cat.#:CTLA4-1106HTag:HlgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 Protein (Met1-Phe162), HlgG1 Fc-tagged, Biotinylated
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Cat.#:CTLA4-257HTag:His|Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 Protein, His-Avi-tagged, Biotinylated
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Cat.#:CTLA4-369CTag:His
Source (Host):HEK293Species:Cynomolgus / Rhesus Monkey
Product nameRecombinant Cynomolgus / Rhesus Monkey CTLA4 Protein, His-tagged
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Cat.#:CTLA4-370CTag:Fc
Source (Host):HEK293Species:Cynomolgus / Rhesus Monkey
Product nameRecombinant Cynomolgus / Rhesus Monkey CTLA4 Protein, Fc-tagged
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Cat.#:CTLA4-371HTag:MIgG2a Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 Protein, MIgG2a Fc-tagged, low endotoxin
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Cat.#:CTLA4-372RTag:Fc
Source (Host):HEK293Species:Rabbit
Product nameRecombinant Rabbit CTLA4 Protein, Fc-tagged
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Cat.#:CTLA4-499HTag:HIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 Protein (Met1-Phe162), HIgG1 Fc-tagged
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Cat.#:CTLA4-500HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 Protein (Met1-Asp161)
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Cat.#:CTLA4-2073PTag:His|Flag|StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant CTLA4 Protein, His-Flag-StrepII-tagged
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Cat.#:CTLA4-2075HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CTLA4 Protein, GST-tagged
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Cat.#:CTLA4-3358MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse CTLA4 Protein, Fc-tagged
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Cat.#:CTLA4-4413BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine CTLA4 Protein
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Cat.#:CTLA4-137HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Humancytotoxic T-lymphocyte-Associated Protein 4
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Cat.#:CTLA4-1598HTag:Fc|His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Cytotoxic T-lymphocyte-associated Protein 4, Fc-His
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Cat.#:CTLA4-160HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CTLA4, Fc-tagged
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Cat.#:CTLA4-1913HTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTLA4, Fc Chimera
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Cat.#:CTLA4-2232HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4, His tagged
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Cat.#:CTLA4-2233HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4, Fc-His tagged
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Cat.#:CTLA4-2234HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 protein, Fc-tagged
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Cat.#:CTLA4-2235HTag:Twin Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 protein, Twin Strep-tagged
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Cat.#:CTLA4-228HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4, C13&N15-labeled
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Cat.#:CTLA4-255HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4, His-tagged, Biotinylated
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Cat.#:CTLA4-256HTag:Avi|Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 protein, Fc/Avi-tagged, Biotinylated
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Cat.#:CTLA4-28029THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human CTLA4, Fc-tagged
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Cat.#:CTLA4-3256HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human CTLA4, MIgG2a Fc-tagged
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Cat.#:CTLA4-3258HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CTLA4, HIgG1 Fc-tagged, mutant
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Cat.#:CTLA4-344HTag:DDK|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 Protein, DDK/His-tagged
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Cat.#:CTLA4-54HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CTLA4 protein, His-tagged
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Cat.#:CTLA4-593HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CTLA4, Fc-tagged, Biotinylated
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Cat.#:CTLA4-7259HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CTLA4, His-tagged
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Cat.#:Ctla4-1717MTag:Fc|His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ctla4, Fc-His
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Cat.#:Ctla4-3261MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ctla4, Fc tagged
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Cat.#:Ctla4-3307MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ctla4, His tagged
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Cat.#:Ctla4-333MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ctla4, MIgG2a Fc-tagged, mutant
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Cat.#:Ctla4-41MTag:His|HIgG
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Ctla4 Protein, hIgG-His-tagged
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Cat.#:Ctla4-4556MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Ctla4, MIgG2a Fc-tagged
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Cat.#:Ctla4-4557MTag:MIgG2a Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ctla4 Protein, MIgG2a Fc-tagged
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Cat.#:Ctla4-5839MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ctla4 protein, His & T7-tagged
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Cat.#:Ctla4-1143RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ctla4 Protein, Fc-tagged
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Cat.#:Ctla4-1144RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ctla4 Protein, His-tagged
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Cat.#:Ctla4-5840RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ctla4 protein, His & T7-tagged
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Cat.#:CTLA4-109CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CTLA4 protein, His-tagged
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Cat.#:CTLA4-192CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey CTLA4 protein, Fc-tagged
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Cat.#:CTLA4-354CTag:Avi|His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CTLA4 protein, Avi & His-tagged, Biotinylated
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Cat.#:CTLA4-8852CTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CTLA4 protein, Fc-tagged
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Cat.#:CTLA4-1077RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CTLA4 Protein, His-tagged
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Cat.#:CTLA4-1060CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CTLA4 Protein, Fc-tagged
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Cat.#:CTLA4-1061CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CTLA4 Protein, His-tagged
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Cat.#:CTLA4-3408CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CTLA4
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Cat.#:CTLA4-2526HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human CTLA4 cell lysate
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Cat.#:CTLA4-2179MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CTLA4 cell lysate
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Cat.#:CTLA4-1047CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CTLA4 cell lysate
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Cat.#:Kit-1712Tag:N/A
Source (Host):Species:
Product nameCTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit
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Cat.#:Kit-1713Tag:N/A
Source (Host):Species:
Product nameCTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit
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Cat.#:CTLA4-155HGTag:Fc
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human CTLA4 Protein
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Cat.#:CTLA4-P03HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CTLA4, Fc-tagged therapeutic protein
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Involved Pathway

Ctla4 involved in several pathways and played different roles in them. We selected most pathways Ctla4 participated on our site, such as Adaptive Immune System, Autoimmune thyroid disease, CTLA4 inhibitory signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctla4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
UBE2V1; SEC24A; ASB9; MGC174152; MAPKAP1; UBE2E3; CTSC; SIGLEC9; AP1S1; KLRB1B
Autoimmune thyroid disease
CTLA4; IFN-a; IL10; CGA; OSTN
CTLA4 inhibitory signaling
CTLA4
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
EGR1; BATF3; DGKA; EGR3; IRF4; CTLA4; EGR4; CSF2; POU2F1; EGR2
Cell adhesion molecules (CAMs)
ICAM3; CDH3; JAM3; CLDN2; MPZ; PDCD1; CLDN11B; JAM2A; OCLNB; ITGA4
Costimulation by the CD28 family
CSK; HLA-DQB2; PDPK1A; BTLA; MAPKAP1; MAP3K8; THEM4; CTLA4
Immune System
CTSC; TRIM38; WIPF2; NLRP4C; CR1; PVRL2L; TXNIPB; CFHL4; SPSB4; SAMHD1
Rheumatoid arthritis
LTB; ATP6V1F; GM-CSF; IL6; TNFSF13B; Ccl12; HLA-DRB4; ATP6V1B1; CXCL5; CCL5

Protein Function

Ctla4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctla4 itself. We selected most functions Ctla4 had, and list some proteins which have the same functions with Ctla4. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein FOXR2; VAMP8; U2AF1; KCNE2; RPLP0; NR4A1; TOPORS; ERP27; PLXND1; TNNI2

Interacting Protein

Ctla4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctla4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctla4.
CD86; PIK3R1; CD80; FYN; STAT5A; STAT5B; RAPGEF1; RAB8A; TRIM25; LAX1

Ctla4 Related Articles

Venditti, O; De Lisi, D; et al. Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis. BMC CANCER 15:-(2015).
Garin, EH; Reiser, J; et al. Case series: CTLA4-IgG1 therapy in minimal change disease and focal segmental glomerulosclerosis. PEDIATRIC NEPHROLOGY 30:469-477(2015).