IL4R Protein, interleukin 4 receptor

IL4R

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IL4R

Official Full Name interleukin 4 receptor
Background This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
Synonyms IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA
    • Species :
    • Cynomolgus/Rhesus macaque
    • Human
    • Pig
    • Rat
    • Source :
    • A293 cells
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • NSO
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • GST
    • His
    • Avi
    • SUMOstar
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL4R-2037H Recombinant Human IL4R Protein, His-tagged HEK293 His
    Pig IL4R-2388P Recombinant Pig IL4R Protein (33-240 aa), His-tagged E.coli His
    Pig IL4R-2437P Recombinant Pig IL4R Protein (33-240 aa), His-sumostar-tagged Yeast His/SUMOstar
    Human IL4R-390H Recombinant Human IL4R protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL4R-1238H Recombinant Human Interleukin 4 Receptor A293 cells N/A
    Human IL4R-1645H Recombinant Human Interleukin 4 Receptor NSO N/A
    Human IL4R-2719HCL Recombinant Human IL4R cell lysate Human Cell N/A
    Human IL4R-284H Recombinant Human Interleukin 4 Receptor, His-tagged Mammalian Cell His
    Human IL4R-28641TH Recombinant Human IL4R, Fc-tagged Fc
    Human IL4R-5179H Recombinant Human IL4R Protein, GST-tagged Wheat Germ GST
    Human IL4R-5180H Recombinant Human IL4R Protein Wheat Germ N/A
    Human IL4R-586H Recombinant Human Interleukin 4 Receptor HEK293 N/A
    Human IL4R-587H Recombinant Human IL4R protein, His-tagged HEK293 His
    Human IL4R-588H Recombinant Human IL4R Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Rat IL4R-1051RCL Recombinant Rat IL4R cell lysate Human Cell N/A
    Rat Il4r-2131R Recombinant Rat Il4r protein, His-tagged E.coli His
    Rat Il4r-379R Recombinant Rat Il4r, Fc tagged Human Cell Fc
    Cynomolgus/Rhesus macaque IL4R-18C Recombinant Cynomolgus/Rhesus macaque IL4R protein, His-tagged HEK293 His
    Cynomolgus/Rhesus macaque IL4R-19C Recombinant Cynomolgus/Rhesus macaque IL4R protein, Fc-tagged HEK293 human/IgG1/Fc

    IL4R involved in several pathways and played different roles in them. We selected most pathways IL4R participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IFN-a; TNFRSF18; CCR8; CRLF2; IFNB1; CCR6; TNFRSF10A; CCL21; TNFSF8; IL9R
    PIK-Akt signaling pathway Kitl; FOXO3; PKN3; OSMR; PDGFRB; EIF4E1B; RAC1; FGFR3; CREB3L2; Ifna15
    Jak-STAT signaling pathway IL4R; OSM; CRLF2; CRFB16; IL7R; IL28A; PRP2; IL20RB; IL15; BCL2
    Hematopoietic cell lineage IL5; CR2; Il4ra; CD59A; TNF; KITLG; CD3E; CD3D; CD33; IL6; GYPA
    Inflammatory bowel disease (IBD) HLA-DRB4; GATA3; MAF; IL23; IL1B; HLA-DQA2; TGFB3; IL21R; IL17F; Il2

    IL4R has several biochemical functions, for example, interleukin-4 receptor activity, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4R itself. We selected most functions IL4R had, and list some proteins which have the same functions with IL4R. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-4 receptor activity IL4R
    protein binding MIPOL1; C8orf4; FOXRED2; ADAM15; MET; DMKN; NLGN3; UBA2; TFIP11; PPIA
    receptor signaling protein activity KLK1B3; RAF1A; FCGR1A; ARF1; IFITM1; RGS14; RGS12; TYROBP; NGF; FCAR

    IL4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4R.

    IL4; IL2RG; STAT6; IL13RA1

    Biedermann, T; Werfel, T; et al. Status quo and prospects for systemic therapy of atopic dermatitis. Biologics ante portas. HAUTARZT 66:108-113(2015).
    Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).

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