il4r
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  • Official Full Name
  • interleukin 4 receptor
  • Background
  • This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.
  • Synonyms
  • IL4R; interleukin 4 receptor; interleukin-4 receptor subunit alpha; CD124; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain; IL4RA; IL-4RA
Cat.#:IL4R-2037HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL4R Protein, His-tagged
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Cat.#:IL4R-2388PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL4R Protein (33-240 aa), His-tagged
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Cat.#:IL4R-2437PTag:His-sumostar
Source (Host):YeastSpecies:Pig
Product nameRecombinant Pig IL4R Protein (33-240 aa), His-sumostar-tagged
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Cat.#:IL4R-390HTag:HIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL4R Protein (Met1-His232), HIgG1 Fc-tagged
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Cat.#:IL4R-5179HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL4R Protein, GST-tagged
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Cat.#:IL4R-5180HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL4R Protein
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Cat.#:IL4R-28641THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human IL4R, Fc-tagged
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Cat.#:IL4R-587HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL4R Protein, His-tagged
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Cat.#:IL4R-588HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL4R Protein, His & Avi-tagged, Biotinylated
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Cat.#:Il4r-2131RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il4r protein, His-tagged
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Cat.#:Il4r-379RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il4r, Fc tagged
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Cat.#:IL4R-18CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL4R Protein, His-tagged
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Cat.#:IL4R-19CTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus IL4R Protein, Fc-tagged
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Cat.#:IL4R-1645HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Interleukin 4 Receptor
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Cat.#:IL4R-284HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human Interleukin 4 Receptor, His-tagged
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Cat.#:IL4R-586HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 4 Receptor
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Cat.#:IL4R-1238HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 4 Receptor
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Cat.#:IL4R-2719HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL4R cell lysate
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Cat.#:IL4R-1051RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat IL4R cell lysate
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Involved Pathway

IL4R involved in several pathways and played different roles in them. We selected most pathways IL4R participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL4R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCL17; BMPR1BA; Il4ra; AMH; LTBR; IL11; CSH; IL6ST; GHR; IL4
PIK-Akt signaling pathway
COL27A1; RAC1; GNG10; FASLG; PIK3CB; MAPK3; CRTC2; IFNA17; CCNE1; LAMA2
Jak-STAT signaling pathway
IL12B; GRB2; M17; AKT2L; IL17D; MCL1A; FHL1; IFNA1; CSF3; IL22RA1
Hematopoietic cell lineage
Kitl; CD1E, B2M; HLA-DRB1; Flt3l; Itga10&Itgb1; CD36; CD3G; IL4; ITGA5; FCGR1
Inflammatory bowel disease (IBD)
STAT1; RELA; HLA-DRB1; IL12RB2; Il23a; IL2RG; TLR5; NFKB1; HLA-DPA1; NFATC1

Protein Function

IL4R has several biochemical functions, for example, interleukin-4 receptor activity, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL4R itself. We selected most functions IL4R had, and list some proteins which have the same functions with IL4R. You can find most of the proteins on our site.
Function
Related Protein
Function interleukin-4 receptor activity
Related Protein IL4R
Function protein binding
Related Protein NFYA; HNF4A; REEP5; CALCOCO1; HIPK1; LDLRAD1; DHX9; SNTB1; SGK3; ZBTB7C
Function receptor signaling protein activity
Related Protein RGS12B; FLRT2; DAXX; PLCE1; IL4R; FLRT3; CD3E; TGFBR1; ADRB1; ARF1

Interacting Protein

IL4R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL4R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL4R.
IL4; IL2RG; STAT6; IL13RA1

IL4R Related Articles

Biedermann, T; Werfel, T; et al. Status quo and prospects for systemic therapy of atopic dermatitis. Biologics ante portas. HAUTARZT 66:108-113(2015).
Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).

IL4R Related Gene Family

IL