Il1b Protein, interleukin 1 beta


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Official Full Name interleukin 1 beta
Background Interleukin-1 beta (IL-1β) also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1β. This antibody is a human monoclonal anti-human IL1Beta antibody of the IgG1/ Kappa isotype. It binds to human IL1Beta and neutralizes its activity by blocking its interaction with IL1 receptors, but it does not bind IL1α or IL1 receptor antagonist (IL1 ra).
Synonyms Il1b; RP23-384K11.2; IL-1beta; Il-1b; Catabolin; IL-1; Lymphocyte-activating factor; LAF; Endogenous Pyrogen; EP; Leukocyte Endogenous Mediator; LEM; Mononuclear Cell Factor; MCF; IL1F2, Interleukin-1 beta; pro-interleukin-1-beta; Interleukin-1 beta precursor; preinterleukin 1 beta; H1; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL-1 beta; IL1 BETA; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; Interleukin-1 beta; OAF; Osteoclast activating factor; OTTHUMP00000162031; Preinterleukin beta; Pro interleukin 1 beta; Gene name: IL1B; NM_000576.2; NP_000567.1; UniProt ID: P01584; P01584; 2q14; Canakinumab; Ilaris; Entrez: 3553; Entrez Gene: 3553; Gene ID: 3553; MIM: 147720; IL1-BETA
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus Monkey
    • Dog
    • Feline
    • Guinea pig
    • Horse
    • Human
    • Monkey
    • Mouse
    • Ovine
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Sheep
    • Zebrafish
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Human Cells
    • Mammalian Cell
    • Monkey
    • Rabbit
    • Yeast
    • Tag :
    • Fc
    • GST
    • HIgG1 Fc
    • His
    • S
    • T7
    • Met
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL1B-132H Recombinant Human IL1B Protein E. coli N/A
    Human IL1B-364H Recombinant Human IL1B Protein Human Cells N/A
    Human Il1B-466H Recombinant Human Il1B, HIgG1 Fc-tagged CHO HIgG1 Fc
    Mouse Il1b-100M Recombinant Mouse Il1b Protein E.coli
    Mouse Il1b-101M Recombinant Mouse Il1b Protein E.coli
    Mouse Il1b-102M Recombinant Mouse Il1b Protein E.coli
    Mouse Il1b-103M Recombinant Mouse Il1b Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human Il1B-39H Recombinant Human Il1B protein, low endotoxin E.coli
    Pig IL1B-82P Recombinant Pig IL1B protein E.coli N/A
    Canine IL1B-920C Recombinant Canine IL1B Protein (Ala115-Ser266) E.coli N/A
    Human CAB11564RH Rabbit Anti-Human IL1B / IL1F2 Monoclonal Antibody Rabbit N/A
    Human IL1B-027E Recombinant Human IL1B (117-269aa) E.coli N/A
    Human IL1B-02H Recombinant Human IL1B protein E.coli N/A
    Human IL1B-134H Recombinant Human Interleukin 1, Beta, His-tagged E.coli His
    Human IL1B-14167H Recombinant Human IL1B, GST-tagged E.coli GST
    Human IL1B-23H Recombinant Human IL1B E.coli N/A
    Human IL1B-321H Recombinant Human IL1B, His-tagged E.coli His
    Human IL1B-339H Recombinant Human IL1B Human N/A
    Human IL1B-4316HG GMP Recombinant Human IL1B protein E.coli N/A
    Human IL1B-460H Recombinant Human IL1B protein, His-tagged HEK293 His
    Human IL1B-461H Recombinant Human Interleukin 1, Beta E.coli N/A
    Human Il1B-464H Recombinant Human Il1B, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL1B-465H Recombinant Human IL1B, MIgG2a Fc-tagged CHO Fc
    Human IL1B-60H Recombinant Human IL1B, His-tagged E.coli His
    Human IL1B-744H Recombinant Human IL1B, His tagged E.coli His
    Human IL1b-82H Recombinant Human IL-1 beta Yeast N/A
    Human IL1B-83H Human Interleukin-1 Beta (rDNA derived) Reference standard N/A
    Human IL1B-853HCL Recombinant Human IL1B cell lysate N/A
    Human IL1B-9908H Recombinant Human IL1B CHO N/A
    Mouse Il1b-040E Recombinant Mouse Il1b (118-269aa), Met tagged E.coli N/A
    Mouse Il1b-04M Recombinant Mouse Il1b protein E.coli N/A
    Mouse Il1b-105M Recombinant Mouse Interleukin 1 Beta, His-tagged E.coli His
    Mouse Il1b-133M Mouse Interleukin-1 beta (rDNA derived) Reference standard N/A
    Mouse Il1b-2830M Recombinant Mouse Il1b protein, His & GST-tagged E.coli His/GST
    Mouse Il1b-2831M Recombinant Mouse Il1b protein, His & T7-tagged E.coli His/T7
    Mouse Il1b-383M Recombinant Mouse Il1b, None tagged E.coli N/A
    Mouse Il1b-462M Recombinant Mouse Interleukin 1 Beta E.coli N/A
    Mouse Il1b-509M Recombinant Mouse Il1b protein, His-tagged HEK293F His
    Mouse Il1b-603M Recombinant Mouse Il1b E.coli Met
    Mouse IL1B-8135M Recombinant Mouse IL1B Protein Mammalian Cell His
    Mouse Il1b-8899M Recombinant Mouse Il1b CHO N/A
    Rat Il1b-384R Recombinant Rat Il1b, His tagged E.coli His
    Rat Il1b-463R Recombinant Rat Interleukin-1 beta E.coli N/A
    Rat IL1B-577R Recombinant Rat IL1B, His tagged E.coli His
    Rat Il1b-93R Recombinant Rat Il1b protein E.coli N/A
    Cynomolgus Monkey IL1B-1167C Recombinant Cynomolgus IL1B Protein E.coli N/A
    Rhesus Macaque IL1B-2239R Recombinant Rhesus monkey IL1B Protein, His-tagged Mammalian Cell His
    Rhesus IL1B-559R Recombinant Rhesus IL1B protein E.coli N/A
    Canine IL1B-243C Recombinant Canine Interleukin 1, Beta Yeast N/A
    Canine Il1b-25C Recombinant Canine IL-1 beta Yeast N/A
    Dog IL1B-2827D Recombinant Dog IL1B protein, His-tagged E.coli His
    Canine IL1B-656C Recombinant Canine IL1B E.coli N/A
    Bovine IL1B-232B Recombinant Bovine Interleukin 1, Beta Yeast N/A
    Chicken IL1B-1782C Recombinant Chicken IL1B protein, His-tagged E.coli His
    Rabbit IL1B-2834R Recombinant Rabbit IL1B protein, His & T7-tagged E.coli His/T7
    Chicken IL1B-589C Recombinant Chicken Interleukin 1, Beta E.coli N/A
    Chicken IL1B-6093C Recombinant Chicken IL1B Mammalian Cell His
    Rabbit IL1B-667R Recombinant Rabbit IL1B E.coli N/A
    Zebrafish IL1B-12106Z Recombinant Zebrafish IL1B Mammalian Cell His
    Pig IL1B-1024P Recombinant Pig IL1B Protein E.coli N/A
    Feline IL1B-1030F Recombinant Feline IL1B Protein E.coli N/A
    Horse IL1B-251E Recombinant Horse IL1B protein E.coli N/A
    Feline IL1B-259F Recombinant Feline Interleukin 1, Beta Yeast N/A
    Cattle IL1B-2826C Recombinant Cattle IL1B protein, His & T7-tagged E.coli His/T7
    Horse IL1B-2828H Recombinant Horse IL1B protein, His-tagged E.coli His
    Guinea pig Il1b-2829G Recombinant Guinea pig Il1b protein, His & S-tagged E.coli His/S
    Sheep IL1B-2832S Recombinant Sheep IL1B protein, His & T7-tagged E.coli His/T7
    Pig IL1B-2833P Recombinant Pig IL1B protein, His-tagged E.coli His
    Cotton Rat Il1b-390C Recombinant Cotton Rat Il1b, Met-tagged E.coli Met
    Monkey IL1B-394M Recombinant Monkey Interleukin 1 Beta Monkey N/A
    Ovine IL1b-56O Recombinant Ovine IL-1 beta Yeast N/A
    Pig IL1β-82P Recombinant Porcine Interleukin-1 beta E.coli N/A

    Il1b involved in several pathways and played different roles in them. We selected most pathways Il1b participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway DDIT3; GNG12A; GRB2B; HSPA1B; RRAS2; RAP1A; MAP3K4; PPM1A; FGF4; MAPK8IP3
    Cytokine-cytokine receptor interaction CLCF1; IFNA4; CXCR5; PDGFB; IL12RB2; IFNL3; CCR10; CXCL11; CXCL6; CX3CL1
    NF-kappa B signaling pathway CFLAR; MAP3K7; LY96; CD40; GM10591; CCL4L2; MAP3K14; LTBR; Ccl21a; RELA
    Osteoclast differentiation FOSL1; ACP5; LCP2; AKT2; MAP2K7; SYK; PLCG2; SIRP-BETA; IKBKG; TGFB2
    Toll-like receptor signaling pathway IL12B; CD40; AKT2L; IFNA2; MAP2K3; NFKBIA; IFNA17; MAP2K4B; IKBKB; PIK3R2
    NOD-like receptor signaling pathway MAPK13; CASP5; SGUT1; NFKBIAB; PSTPIP1A; MAPK10; PYDC1; LOC100033925; IL-8; PYCARD
    Cytosolic DNA-sensing pathway IRF3; DDX58; IL18; LOC100033925; IFNA16; POLR3GL; NFKBIAA; TMEM173; CASP1; IFNA10
    Hematopoietic cell lineage Flt3l; CD36; IL1R1; THPO; ITGA5; CD1D; ITGA6; CD1D2; CD22; CD1C
    TNF signaling pathway MAP2K1; BAG4; TNFRSF1A; RPS6KA5; LIF; MAPK12; CXCL1; MLKL; RPS6KA4; TRAF2
    Inflammatory mediator regulation of TRP channels IGF1; PTGER4; PLA2G4C; ITPR3; CALM2; PLCG2; PIK3CD; CYP4A10; CYP2J5; HTR2B
    Non-alcoholic fatty liver disease (NAFLD) BAX; RXRA; UQCRC2; DDIT3; NDUFA6; AKT1; NDUFC1; NDUFB4; Il6ra; NDUFA10
    Type I diabetes mellitus ICA1; CD28; PTPRN2; IL1B; GAD1; Fasl; CD86; FAS; IL12B; HLA-A
    Alzheimers disease BAD; BACE1; NDUFC2; ATP5B; ATP5A1; SDHD; COX6C; NDUFB2; CASP12; CDK5
    Prion diseases HSPA5; MAP2K1; PRKACB; SOD1; C5; FYN; PRKACA; PRNP; IL6; C8A
    Salmonella infection RAC1A; CCL3; NOS2B; ROCK1; PYCARD; DYNC1LI2; FLNC; LBP; ACTB2; DYNC1I2A
    Pertussis MAPK9; GNAI2; Itgam&Itgb2; ITGAM; C3; MAPK1; IL23; ITGA5; Casp3; TRAF6
    Legionellosis RAB1; MYD88; NAIP6; HSPA1A; BCL2L13; CR1; VCP; HSPA2; EEF1A1; HBS1L
    Leishmaniasis NCF2; IFNGR2; TAB2; HLA-DRB1; ITGB2; ELK1; FCGR3; PTPN6; FCGR4; HLA-DQB1
    Chagas disease (American trypanosomiasis) C3; TICAM1; TNF; IRAK4; TLR4; IKBKG; FAS; TGFB2; PLCB3; NFKBIA
    African trypanosomiasis PLCB1; IL18; VCAM1; PLCB2; PRKCG; IDO1; IL12B; HBA2; APOA1; LAMA4
    Malaria IL18; HBA1; SELE; THBS2; SELP; VCAM1; CD81; GYPC; MYD88; DARC
    Tuberculosis VDR; TNF; ATP6AP1; FCGR2A; IRAK2; IFNA21; ATP6V0C; TGFB3; TLR1; HLA-DOB
    Measles IFNGR2; CD3G; MX1; PIK3CA; IFNB1; CCND3; CD3E; CD3D; IFNA12; RELA; IL1A
    Herpes simplex infection Ifna11; JAK2B; TAP1; PTPN11; STAT1B; C3A.3; DAXX; THOC4; MHC2DAB; POU2F3
    Inflammatory bowel disease (IBD) IL12RB2; RORC; TLR4; Il23a; Il12b; Il23a; STAT4; H2-AB1; SMAD3; RORA; TLR2
    Rheumatoid arthritis IL18; ATP6V0D2; CD28; HLA-DPA1; ATP6V0D1; CTLA4; ICAM1; ATP6V1B2; TNFSF11; TNFRSF11A
    Graft-versus-host disease HLA-DQA1; IL6; GZMB; HLA-DRA; CD28; HLA-DQA2; HLA-A; KIR3DL2; FAS; HLA-G

    Il1b has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding, protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1b itself. We selected most functions Il1b had, and list some proteins which have the same functions with Il1b. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity BMP15; CLCF1; GM13288; IL36B; GPR19; LTA; LTB; IL7; IL1RN; GM13289
    interleukin-1 receptor binding IL1B; Il1f6; IL36A; IL36G; IL36B; IL1RN; IRAK4; IL36RN; TLR5; IL37
    protein domain specific binding YWHAG1; RXRA; WNT3; STX1A; CNTLN; ABCC2; HIST1H4H; ZNF521; PRKCI; BASP1

    Il1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1b here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1b.

    IL1RAP; saicar; PKM; IL1R1; A2M; IKBKG; MYC

    McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
    Leal, RF; Planell, N; et al. Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNF alpha therapy. GUT 64:233-242(2015).

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