cd4
Share
  • Official Full Name
  • CD4 molecule
  • Background
  • This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
  • Synonyms
  • CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3;
Cat.#:CD4-23HTag:Fc & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4 Protein, Fc & Avi-tagged
+Inquiry
Cat.#:CD4-24HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4 Protein, His & Avi-tagged
+Inquiry
Cat.#:CD4-313HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4 Protein (Lys 26 - Pro 396), His & Avi-tagged, Biotinylated
+Inquiry
Cat.#:CD4-314HTag:Fc/Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4 Protein (Lys 26 - Pro 396), Fc & Avi-tagged, Biotinylated
+Inquiry
Cat.#:CD4-803MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD4 Protein (Met1-Thr394), His-tagged, Biotinylated
+Inquiry
Cat.#:CD4-0806HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD4 Protein
+Inquiry
Cat.#:CD4-0807HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD4 Protein, GST-Tagged
+Inquiry
Cat.#:CD4-3030HTag:Fc Chimera
Source (Host):HEK293(Human Cells)Species:Human
Product nameRecombinant Human CD4, Fc Chimera
+Inquiry
Cat.#:CD4-0809MTag:His
Source (Host):HEK293Species:Monkey
Product nameRecombinant Monkey CD4 Protein, His-Tagged
+Inquiry
Cat.#:CD4-101HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD4 Molecule, His-tagged (125-202aa)
+Inquiry
Cat.#:CD4-102HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD4 Molecule, His-tagged(203-317aa)
+Inquiry
Cat.#:CD4-103HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD4 Molecule(26-226aa)
+Inquiry
Cat.#:CD4-104HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD4 Molecule (411-459)
+Inquiry
Cat.#:CD4-99HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Soluble CD4 Molecule
+Inquiry
Cat.#:CD4-016HTag:Fc
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human CD4 Protein, Fc-tagged
+Inquiry
Cat.#:CD4-10954HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD4, GST-tagged
+Inquiry
Cat.#:CD4-1559HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD4 protein, His-tagged
+Inquiry
Cat.#:CD4-19HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4 protein, MYC/DDK-tagged
+Inquiry
Cat.#:CD4-2219HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4, Fc-His tagged
+Inquiry
Cat.#:CD4-2220HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4 Protein, Fc-tagged
+Inquiry
Cat.#:CD4-234HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4, StrepII-tagged
+Inquiry
Cat.#:CD4-26367THTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CD4
+Inquiry
Cat.#:CD4-27808THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD4
+Inquiry
Cat.#:CD4-27809THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD4
+Inquiry
Cat.#:CD4-3167HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4 protein, His-tagged
+Inquiry
Cat.#:CD4-3836HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4, His tagged
+Inquiry
Cat.#:Cd4-1560MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd4 protein, His-tagged
+Inquiry
Cat.#:Cd4-2276MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd4, His tagged
+Inquiry
Cat.#:CD4-1075RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD4 Protein, His-tagged
+Inquiry
Cat.#:CD4-1252RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CD4 Protein
+Inquiry
Cat.#:CD4-143CTag:DDDDK
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD4, His tagged
+Inquiry
Cat.#:CD4-1562RTag:His/S
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey CD4 protein, His & S-tagged
+Inquiry
Cat.#:CD4-169CTag:His
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus CD4 protein, His-tagged
+Inquiry
Cat.#:CD4-377RTag:His
Source (Host):HEK293Species:Rhesus macaque
Product nameRecombinant Rhesus macaque CD4 protein, His-tagged
+Inquiry
Cat.#:CD4-739RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD4 Protein, His-tagged
+Inquiry
Cat.#:CD4-740RTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD4, Fc-tagged
+Inquiry
Cat.#:CD4-1561RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit CD4 protein, His & GST-tagged
+Inquiry
Cat.#:CD4-6217CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CD4
+Inquiry
Cat.#:CD4-7178ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CD4
+Inquiry
Cat.#:CD4-1023FTag:His
Source (Host):HEK293Species:Ferret
Product nameRecombinant Ferret CD4 Protein, His-tagged
+Inquiry
Cat.#:CD4-634FTag:His
Source (Host):NSO cellsSpecies:Feline
Product nameRecombinant Feline CD4, His-tagged
+Inquiry
Cat.#:CD4-1905HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD4 cell lysate
+Inquiry
Cat.#:CD4-2580MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD4 cell lysate
+Inquiry
Cat.#:CD4-947CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD4 cell lysate
+Inquiry
Cat.#:CD4-1865FCLTag:
Source (Host):HEK293Species:Ferret
Product nameRecombinant Ferret CD4 cell lysate
+Inquiry
Cat.#:CD4-P022HTag:
Source (Host):Pneumonas aeruginosa exotoxin ASpecies:Human
Product nameRecombinant Human CD4 therapeutic protein
+Inquiry
Cat.#:CDA078PTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD-4
+Inquiry
Cat.#:CSC-H0173Tag:
Source (Host):Species:Bovine
Product nameMouse Anti-Bovine CD4 Hybridoma
+Inquiry
Cat.#:CSC-H0008Tag:
Source (Host):Species:Sheep
Product nameMouse Anti-Sheep CD4 Hybridoma
+Inquiry

Involved Pathway

CD4 involved in several pathways and played different roles in them. We selected most pathways CD4 participated on our site, such as Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
HLA-C; TIGIT; SPN; SDC3; NRXN2A; NLGN2; NCAM1A; Itgam&Itgb2; NFASCA; SELL
Antigen processing and presentation
CTSL1; HSPA1A; NFYC; HLA-E; HLA-DQA1; NFYA; KIR2DS3; HLA-DRA; KIR2DS2; CTSB
Hematopoietic cell lineage
IL1A; CD22; Itgam&Itgb2; CR2; CD34; IL11RA2; ITGA3; HLA-DRA; CD3D; CD3G
T cell receptor signaling pathway
MAPK11; OXSR1A; GRB2; RAF1; VAV2; NFKBIB; PPP3CA; MAPK9; CD8A; GRAPA
Primary i
RFXANK; IGLL1; CD4; ORAI1; CD3D; CD8B; Cd79a, Cd79b; IKBKG; CD40; IL2RG
nodeficiency
UNG; RFX5; TNFRSF13B; RAG1; ICOS; RAG2; Cd79a, Cd79b; RFXAP; CD8A; CD3E

Protein Function

CD4 has several biochemical functions, for example, MHC class II protein binding, coreceptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD4 itself. We selected most functions CD4 had, and list some proteins which have the same functions with CD4. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class II protein binding
Related Protein MARCH8; CD74B; CD74A; LAG3; CD74; KRT17; CD4
Function coreceptor activity
Related Protein RAMP3; CXCR7B; IGSF1; CXCR6; PVRL1; ACKR3B; CXCR4; NRP1; CD8B; CD4
Function enzyme binding
Related Protein PPP3CB; CYP2A4; HAND1; TMBIM6; PLSCR1; UGT1A2; RARA; H2AFX; MST1R; PRKCE
Function extracellular matrix structural constituent
Related Protein CHI3L1; IMPG1; FBN1; COL3A1; COL4A5; COL4A3; COL5A1; COL2A1B; TFPI2; PRELP
Function glycoprotein binding
Related Protein LMAN2; LDLR; Itgam&Itgb2; TFR2; LRRK2; EDEM1; CD4; BMPR1B; ERBB2; RGMA
Function protein binding
Related Protein ASAP2; NAP1L1; ZFYVE16; CD200R1; EIF3D; LRRC3; NUDT1; MAST2; HSPA9; MX1
Function protein homodimerization activity
Related Protein ANO2; NUDT16; HAND1; FGFR1; FZD9; KCNE2; S100A5; KLRB1B; GREM2; SLC30A8
Function protein kinase binding
Related Protein VDAC1; HIF1A; PEBP1; MAP2K6; CAMK2N2; CHEK2; IL31RA; HSP90AB1; TRIM6; MAP2K7
Function receptor activity
Related Protein HTR3A; NLGN1; LDLR; CADM1; ANTXRL; GRIA2A; MED30; GFRA4A; CCR6; TACSTD2
Function transmembrane signaling receptor activity
Related Protein FZD3A; IL1R1; FZD1; DNER; ICAM1; CD4; LILRB5; TLR2; TLR1; NRXN3
Function virus receptor activity
Related Protein SCARB1; ITGB5; AXL; HYAL2; MRC1; ITGA2; NCAM1; EFNB2; ITGAV; CR2
Function zinc ion binding
Related Protein MARCH5L; ANPEPA; TXNDC17; TRIM69; CAR7; ZDHHC15A; PPARAB; CSRP1B; YAF2; NR4A2B

Interacting Protein

CD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD4.
LCK; CCR5; vpu; vpu; vpu; H2-Aa; trfe_chick; NR3C1; H2-Ab1; tip_shv2c; ACTB; vpu; HRD3; INPPL1

CD4 Related Articles

Chang, B; Sheng, R; et al. Prevalence of Howell-Jolly Body-Like Inclusions in HIV Patients and Their Correlation with CD4 Counts and HIV RNA Viral Load. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:23-26(2015).
Nkala, B; Khunwane, M; et al. Kganya Motsha Adolescent Centre: a model for adolescent friendly HIV management and reproductive health for adolescents in Soweto, South Africa. AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV 27:697-702(2015).

CD4 Related Gene Family

Immunoglobulins