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Official Full Name CD4 molecule
Background This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
Synonyms CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3;
    • Species :
    • Bovine
    • Chicken
    • Cynomolgus Monkey
    • Feline
    • Ferret
    • Human
    • Monkey
    • Mouse
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Sheep
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Pneumonas aeruginosa exotoxin A
    • Rabbit
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Avi
    • Fc
    • DDDDK
    • His
    • GST
    • S
    • His-Avi
    • human
    • IgG1
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD4-23H Recombinant Human CD4 Protein, Fc & Avi-tagged HEK293 Avi/Fc
    Human CD4-24H Recombinant Human CD4 Protein, His & Avi-tagged HEK293 His/Avi
    Mouse Cd4-160MG GMP Recombinant Mouse Cd4 protein, His-tagged HEK293 His
    Human CD4-2864H Recombinant Human CD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CD4-293H Recombinant Human CD4 protein, His-Avi-tagged HEK293 His-Avi
    Human CD4-313H Recombinant Human CD4 Protein (Lys 26 - Pro 396), His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human CD4-314H Recombinant Human CD4 Protein (Lys 26 - Pro 396), Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Mouse CD4-803M Recombinant Mouse CD4 Protein (Met1-Thr394), His-tagged, Biotinylated HEK293 His
    Mouse Cd4-841M Recombinant Mouse Cd4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CABTT-005RH Rabbit Anti-Human CD4 Monoclonal Antibody Rabbit N/A
    Human CD4-016H Recombinant Human CD4 Protein, Fc-tagged HEK293 Fc
    Human CD4-0806H Recombinant Human CD4 Protein Wheat Germ N/A
    Human CD4-0807H Recombinant Human CD4 Protein, GST-Tagged Wheat Germ GST
    Human CD4-101H Recombinant Human CD4 Molecule, His-tagged (125-202aa) E.coli N/A
    Human CD4-102H Recombinant Human CD4 Molecule, His-tagged(203-317aa) E.coli N/A
    Human CD4-103H Recombinant Human CD4 Molecule(26-226aa) E.coli N/A
    Human CD4-104H Recombinant Human CD4 Molecule (411-459) E.coli N/A
    Human CD4-10954H Recombinant Human CD4, GST-tagged E.coli GST
    Human CD4-1559H Recombinant Human CD4 protein, His-tagged E.coli His
    Human CD4-1905HCL Recombinant Human CD4 cell lysate Human Cell N/A
    Human CD4-19H Recombinant Human CD4 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD4-2219H Recombinant Human CD4, Fc-His tagged Human Cell Fc/His
    Human CD4-234H Recombinant Human CD4, StrepII-tagged Human Cell Strep II
    Human CD4-26367TH Recombinant Human CD4 Sf9 Insect Cell N/A
    Human CD4-27808TH Recombinant Human CD4 E.coli N/A
    Human CD4-27809TH Recombinant Human CD4 E.coli N/A
    Human CD4-3167H Recombinant Human CD4 protein, His-tagged HEK293 His
    Human CD4-3836H Recombinant Human CD4, His tagged Human Cell His
    Human CD4-99H Recombinant Human Soluble CD4 Molecule Insect Cell N/A
    Human CD4-P022H Recombinant Human CD4 therapeutic protein Pneumonas aeruginosa exotoxin A N/A
    Human CDA078P Recombinant Human CD-4 E.coli N/A
    Mouse Cd4-1560M Recombinant Mouse Cd4 protein, His-tagged E.coli His
    Mouse Cd4-2276M Recombinant Mouse Cd4, His tagged Human Cell His
    Mouse CD4-2580MCL Recombinant Mouse CD4 cell lysate Human Cell N/A
    Rat CD4-1075R Recombinant Rat CD4 Protein, His-tagged HEK293 His
    Rat CD4-1252R Recombinant Rat CD4 Protein Mammalian Cell His
    Cynomolgus Monkey CD4-143C Recombinant Cynomolgus CD4, His tagged Human Cell DDDDK
    Cynomolgus Monkey CD4-947CCL Recombinant Cynomolgus CD4 cell lysate Human Cell N/A
    Rhesus monkey CD4-1562R Recombinant Rhesus monkey CD4 protein, His & S-tagged E.coli His/S
    Rhesus CD4-169C Recombinant Rhesus CD4 protein, His-tagged HEK293 His
    Rhesus macaque CD4-377R Recombinant Rhesus macaque CD4 protein, His-tagged HEK293 His
    Rhesus Macaque CD4-739R Recombinant Rhesus monkey CD4 Protein, His-tagged Mammalian Cell His
    Rhesus macaque CD4-740R Recombinant Rhesus macaque CD4 protein, Fc-tagged HEK293 human/IgG1/Fc
    Bovine CSC-H0173 Mouse Anti-Bovine CD4 Hybridoma N/A
    Rabbit CD4-1561R Recombinant Rabbit CD4 protein, His & GST-tagged E.coli His/GST
    Chicken CD4-6217C Recombinant Chicken CD4 Mammalian Cell His
    Zebrafish CD4-7178Z Recombinant Zebrafish CD4 Mammalian Cell His
    Monkey CD4-0809M Recombinant Monkey CD4 Protein, His-Tagged HEK293 His
    Ferret CD4-1023F Recombinant Ferret CD4 Protein, His-tagged HEK293 His
    Ferret CD4-1865FCL Recombinant Ferret CD4 cell lysate Human Cell N/A
    Feline CD4-634F Recombinant Feline CD4, His-tagged NS0 His
    Sheep CSC-H0008 Mouse Anti-Sheep CD4 Hybridoma N/A

    CD4 involved in several pathways and played different roles in them. We selected most pathways CD4 participated on our site, such as Cell adhesion molecules (CAMs), Antigen processing and presentation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) ALCAM; CD80; SELPLG; ITGB8; CD86; NEO1; NLGN2; CDH15; F11R.1; ITGA9
    Antigen processing and presentation KIR3DL1; CTSL1; CD8B1; KIR2DS4; KLRD1; KIR2DS2; KLRC3; TNF; NFYA; PDIA3
    Hematopoietic cell lineage IL1A; CD2; IL2RA; CD1C; HLA-DRA; IL5; CD36; ITGA2B; GP5; HLA-DRB4
    T cell receptor signaling pathway TEC; MUC1; PDCD1; NFKBIE; PRKCQ; NFATC1; PTPN6; PLCG1; DBNLB; NCK2
    Primary i ICOS; RAG2; RFXANK; TAP1; IL7R; IL2RG; CD3E; LCK; CD40LG; BTK
    nodeficiency CD19; ICOS; IGLL1; CD8A; LCK; PTPRC; DCLRE1C; AICDA; CD8B1; RFXANK

    CD4 has several biochemical functions, for example, MHC class II protein binding, coreceptor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD4 itself. We selected most functions CD4 had, and list some proteins which have the same functions with CD4. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein binding LAG3; CD74B; MARCH8; CD4; KRT17; CD74A; CD74
    coreceptor activity CXCR4; CXCR6; ZP2; LRP5; CD80; ACVR2A; PVRL1; ACKR3B; RAMP2; CD8A
    enzyme binding HSPA2; SIRT3; UGT1A9; RAC1; CYP1A2; CYP3A4; XRCC1; ANK1; U2AF2; CAT
    extracellular matrix structural constituent PXDN; COL5A2; COL1A1A; COL5A1; IMPG1; EFEMP2; COL4A5; COL1A2; COL8A2; FBN2B
    glycoprotein binding AZGP1; IGF2R; Serpina1c; CDH1; FBXO6; FLNA; FOXRED2; TFRC; FYN; FBXO2
    protein binding KIF7; ZNF3; MMP9; SKP2; WNK1; STRADB; TAF13; DDA1; NEDD9; FIP1L1
    protein homodimerization activity GDF6; GSTZ1; FLNA; SEPT12; LGALS1; GABRR1; UXS1; GPD1A; ZNF174; NTRK2
    protein kinase binding BCAR1; FGR; RFFL; KAT2B; NME2; MAPK8IP2; RPS6; EPHA1; PRKAG2; STK39
    receptor activity CD226; GRIN1B; TREML2; PVRL4; MCC; FOLR1; TRAM1; VMN1R40; NPR2; ITGB8
    transmembrane signaling receptor activity IL1R1; SIGLEC8; CLEC2H; OR6K3; GPR98; ANTXR1; HIST2H3C2; NCR2; CD79A; CLDN3
    virus receptor activity IDE; GYPA; NCAM1; PVRL4; ACE2; SLC52A2; DPP4; EFNB2; ANPEP; SERPINB3
    zinc ion binding NR2F6B; NSMCE1; C6AST3; CA1; MMP14; DPP3; ZCCHC17; TRIM74; ZKSCAN5; ESRRB

    CD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD4.

    LCK; CCR5; vpu; vpu; vpu; H2-Aa; trfe_chick; NR3C1; H2-Ab1; tip_shv2c; ACTB; vpu; HRD3; INPPL1

    Chang, B; Sheng, R; et al. Prevalence of Howell-Jolly Body-Like Inclusions in HIV Patients and Their Correlation with CD4 Counts and HIV RNA Viral Load. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:23-26(2015).
    Nkala, B; Khunwane, M; et al. Kganya Motsha Adolescent Centre: a model for adolescent friendly HIV management and reproductive health for adolescents in Soweto, South Africa. AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV 27:697-702(2015).

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