il23a
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  • Official Full Name
  • interleukin 23, alpha subunit p19
  • Background
  • Interleukin-23 (IL-23) is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit). IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation. Knockout mice deficient in either p40 or p19, or in either subunit of the IL-23 receptor (IL-23R and IL12R-β1) develop less severe symptoms of multiple sclerosis and inflammatory bowel disease highlighting the importance of IL-23 in the inflammatory pathway.
  • Synonyms
  • IL23A; interleukin 23, alpha subunit p19; P19; SGRF; IL-23; IL-23A; IL23P19; MGC79388; interleukin-23 subunit alpha; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation
Cat.#:IL23A-451HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL23A Protein, Fc-tagged
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Cat.#:Il23A-23HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Il23A&IL12B Protein, His-tagged
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Cat.#:Il23a-1927MTag:
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Il23a Protein
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Cat.#:Il23A-001HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il23A, HIgG1 Fc-tagged, mutant
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Cat.#:Il23A-002HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il23A, MIgG2a Fc-tagged
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Cat.#:Il23A-003HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il23A, HIgG1 Fc-tagged
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Cat.#:Il23A-053HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human Il23A protein, GST-tagged
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Cat.#:IL23A-1823HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL23A protein, His & Avi-tagged, Biotinylated
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Cat.#:IL23A-29781THTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL23A, FLAG-tagged
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Cat.#:IL23A-29782THTag:
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human IL23A
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Cat.#:IL23A-553HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL23A Protein, His-tagged
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Cat.#:IL23A-966HTag:
Source (Host):Hi-5 insect cellsSpecies:Human
Product nameRecombinant Human IL23A Protein
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Cat.#:IL23A-967HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IL23A Protein
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Cat.#:IL23A-159MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il23a & Il12b, His tagged
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Cat.#:Il23a-1784MTag:His/SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il23a protein, His & SUMO-tagged
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Cat.#:IL23A-8156MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IL23A Protein
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Cat.#:Il12b&Il23a-747RTag:
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Rat
Product nameRecombinant Rat Il12b&Il23a
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Cat.#:Il23a&Il12b-556RTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il23a&Il12b
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Cat.#:IL23A-3041RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL23A Protein
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Cat.#:IL23A-617CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL23A Protein, His-tagged
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Cat.#:IL23A-2246RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL23A Protein, His-tagged
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Cat.#:IL23A-162MTag:Fc
Source (Host):HEK293Species:Marmoset
Product nameRecombinant Marmoset IL23A & IL12B, His tagged
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Cat.#:Il23a-651MTag:N/A
Source (Host):S. frugiperdaSpecies:Mouse
Product nameRecombinant Mouse Interleukin 23, Alpha Subunit P19
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Cat.#:L23A-269HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Iinterleukin 23, Alpha Subunit P19
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Cat.#:IL23A-239BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Interleukin 23, Alpha Subunit P19
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Cat.#:IL23A-5231HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IL23A 293 Cell Lysate
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Involved Pathway

IL23A involved in several pathways and played different roles in them. We selected most pathways IL23A participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL23A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFRSF11B; CSF1R; PDGFRB; PDGFAA; TNFRSF10B; LIFR; IL12BA; LIFRA; PRP2; CCL8
Jak-STAT signaling pathway
CSF3; IL5; Il2; IFNA10; GRB2; GRB2A; STAT1B; HRASB; IL-15RA; CCND2
Pertussis
IRF1; C1QA; IL12A; Il23a; Il12b; CFL2; RELA; NOS2; CALM2; FOS; CXCL6
Tuberculosis
IFNA5; BCL2; CEBPG; ATP6V0C; RELA; IL18; H2-AB1; MAPK1; HLA-DRB5; TGFB3
Inflammatory bowel disease (IBD)
Il4ra; IFNG; IL5; IL17F; IL22; IL12RB1; STAT1; HLA-DRB3; IL12B; TNF
Rheumatoid arthritis
ATP6V0C; GM-CSF; CD86; HLA-DMA; CCL3L1; MMP3; ITGAL; ATP6V1F; ATP6V1G2; HLA-DOA

IL23A Related Articles

Masaki, K; Suzuki, Y; et al. Dual Role of Interleukin-23 in Epicutaneously-Sensitized Asthma in Mice. ALLERGOLOGY INTERNATIONAL 63:13-22(2014).
Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).