CD3E Protein, CD3e molecule, epsilon (CD3-TCR complex)

CD3E

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CD3E

Official Full Name CD3e molecule, epsilon (CD3-TCR complex)
Background The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Synonyms CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit o; T3E; TCRE; IMD18; T-cell antigen receptor complex,
    • Species :
    • Canine
    • Chicken
    • Cynomolgus
    • Cynomolgus Monkey
    • Cytomegalovirus
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • Flag
    • GST
    • Avi
    • human
    • IgG1
    • Llama
    • IgG2b
    • Myc
    • N/A
    • Strep
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD3E & CD3D-377H Recombinant Human CD3E & CD3D Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Cynomolgus CD3E&CD3G-221C Recombinant Cynomolgus CD3E & CD3G protein, Fc-tagged HEK293 Human/IgG1/Fc
    Cynomolgus CD3E&CD3G-222C Recombinant Cynomolgus CD3E & CD3G protein, Fc-tagged HEK293 Llama/IgG2b/Fc
    Mouse CD3E-1085M Recombinant Mouse CD3E Protein (Met1-Asp108), His-Fc-tagged, Biotinylated HEK293 His/Fc
    Human CD3E-2193H Recombinant Human CD3E Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human CD3E-321H Recombinant Human CD3E Protein, His-tagged CHO His
    Rhesus Cd3e-322R Recombinant Rhesus CD3E Protein, His-tagged HEK293 His
    Human CD3E-463H Recombinant Human CD3E Protein (Met1-Asp126), His-tagged, Biotinylated CHO His
    Rhesus CD3E-982R Recombinant Rhesus CD3E Protein (Met1-Asp117), His-Fc-tagged HEK293 His/Fc
    Human CD3D & CD3E-1714HCL Recombinant Human CD3D & CD3E cell lysate Human Cell N/A
    Human CD3D & CD3E-944HCL Recombinant Human CD3D & CD3E cell lysate Human Cell N/A
    Human CD3E & CD3D-375H Recombinant Human CD3E & CD3D protein, His & Flag-tagged, Biotinylated HEK293 His/Flag
    Human CD3E & CD3D-376H Recombinant Human CD3E & CD3D protein, His-tagged HEK293 His
    Human CD3E & CD3G-251H Recombinant Human CD3E & CD3G protein, His/Fc-tagged HEK293 His/Fc
    Human CD3E & CD3G-342H Recombinant Human CD3E & CD3G protein, His & Fc & Flag-tagged HEK293 His/Fc/Flag
    Human CD3E & CD3G-761HCL Recombinant Human CD3E & CD3G cell lysate Human Cell N/A
    Human CD3E&CD3D-182H Recombinant Human CD3E&CD3D, His-Fc&Flag-Fc tagged HEK293 Flag/Fc/His
    Human CD3E&CD3D-219H Recombinant Human CD3E&CD3D, His&flag-tagged HEK293 His/Flag
    Human CD3E-0803H Recombinant Human CD3E Protein, GST-Tagged Wheat Germ GST
    Human CD3E-10952H Recombinant Human CD3E, GST-tagged E.coli GST
    Human CD3E-1275HCL Recombinant Human CD3E cell lysate Human Cell N/A
    Human CD3E-213H Recombinant Human CD3E protein, His-tagged HEK293 His
    Human CD3E-2194H Recombinant Human CD3E, His tagged Human Cell His
    Human CD3E-2195H Recombinant Human CD3E protein, Strep-tagged HEK293 Strep
    Human CD3E-26926TH Recombinant Human CD3E Wheat Germ N/A
    Human CD3E-275H Recombinant Human CD3E, His-tagged, Biotinylated HEK293 His
    Human CD3E-276H Recombinant Human CD3E protein, Fc-tagged, Biotinylated HEK293 Fc
    Human CD3E-3081H Recombinant Human CD3E Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD3E-576H Recombinant Human CD3E, Fc-tagged Human Cell Fc
    Human CD3E-7071H Recombinant Human CD3E, His-tagged E.coli His
    Human CD3E-829H Recombinant Human CD3E Protein, DDK/His-tagged HEK293 DDK/His
    Human CD3E-8541H Recombinant Human CD3E protein, His/Fc-tagged HEK293 His/human/IgG1/Fc
    Mouse CD3D & CD3E-1076MCL Recombinant Mouse CD3D & CD3E cell lysate Human Cell N/A
    Mouse CD3D & CD3E-1726MCL Recombinant Mouse CD3D & CD3E cell lysate Human Cell N/A
    Mouse Cd3E&D-307M Recombinant Mouse Cd3e&Cd3d, His&Flag tag " Human Cell His/Flag
    Mouse Cd3e-374M Recombinant Mouse Cd3e protein, Fc-tagged HEK293 human/IgG1/Fc
    Rat CD3e-1115R Recombinant Rat CD3e Protein, Fc-tagged HEK293 Fc
    Cynomolgus Monkey CD3D & CD3E-1179CCL Recombinant Cynomolgus CD3D & CD3E cell lysate Human Cell N/A
    Cynomolgus Monkey CD3E&CD3D-187C Recombinant Cynomolgus CD3E&CD3D, His & flag-tagged HEK293 His/Flag
    Cynomolgus Monkey CD3E&CD3D-209C Recombinant Cynomolgus CD3E&CD3D, His-Fc & flag-Fc-tagged HEK293 Flag/Fc/His
    Cynomolgus Monkey CD3E&CD3D-220C Recombinant Cynomolgus CD3E&CD3D, His-Fc&Flag-Fc tagged HEK293 Flag/Fc/His
    Cynomolgus Monkey CD3E-1602CCL Recombinant Cynomolgus CD3E cell lysate Human Cell N/A
    Cynomolgus CD3E-163C Recombinant Cynomolgus CD3E protein, His-tagged HEK293 His
    Cynomolgus CD3E-199C Recombinant Cynomolgus CD3E protein, His/Fc-tagged HEK293 His/human/IgG1/Fc
    Cynomolgus Monkey CD3E-274C Recombinant Cynomolgus CD3E, His-tagged, Biotinylated HEK293 His
    Cynomolgus Monkey CD3E-306C Recombinant Cynomolgus CD3D & CD3E, His-Fc & Flag-Fc tagged Human Cell Fc
    Cynomolgus Monkey CD3E-390C Recombinant Cynomolgus CD3E Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CD3E-1184R Recombinant Rhesus CD3E Protein, Fc-tagged HEK293 Fc
    Canine CD3E-1055C Recombinant Canine CD3E Protein, Fc-tagged HEK293 Fc
    Chicken CD3E-7092C Recombinant Chicken CD3E Mammalian Cell His
    Cytomegalovirus CD3E-113C Recombinant Cynomolgus CD3E, His-tagged HEK293 His
    CD3E&D-308H Recombinant Human CD3E & CD3D, His & Flag tag " Human Cell His/Flag
    Cd3E&D-309M Recombinant Mouse Cd3E&D-309M, His-Fc & Flag-Fc tag Human Cell Flag/Fc/His
    CD3E&D-310H Recombinant Human CD3D & CD3E, Flag-Fc & His-Fc tag Human Cell Flag/Fc/His

    CD3E involved in several pathways and played different roles in them. We selected most pathways CD3E participated on our site, such as Hematopoietic cell lineage, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD3E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hematopoietic cell lineage ITGA2B; Itgam&Itgb2; Il4ra; ITGA3; Flt3l; IL5; CD1C; ITGA1; CSF3R; CD36
    T cell receptor signaling pathway MAP2K2; MAPK12; GRB2; IKBKB; LCK; NFATC2; SLA1; NFKB1; RAF1; PIK3R3
    Chagas disease (American trypanosomiasis) CD3E; CD3D; IL10; CD3E; TRAF6; MYD88; PPP2R2D; CALR; PIK3CG; GNAI1; CXCL8
    Measles GSK3B; OAS1; OAS3; CCND2; EIF3H; AKT1; IFNA10; PIK3R1; IL2RG; Ifna11
    HTLV-I infection SRF; HLA-DOB; CD40; ELK1; WNT2; SLC25A6; Adcy4; HLA-DQB1; HRAS; PIK3R3
    Primary i CD8A; RAG2; PTPRC; RFXAP; AIRE; TNFRSF13B; CD40; TAP1; CD3D; RFXANK
    nodeficiency ZAP70; RFX5; LCK; RAG2; TAP1; UNG; BLNK; RFXAP; CD3E; CD40LG

    CD3E has several biochemical functions, for example, SH3 domain binding, T cell receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD3E itself. We selected most functions CD3E had, and list some proteins which have the same functions with CD3E. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding ADAM12; ARHGAP6; REPS1; ADAM10; EVLB; NCF1; MICAL1; INPP5D; ARHGAP17; CRB3
    T cell receptor binding EPS8L1; FYN; HLA-A; DOCK2; CD1d1; CD3G; H2-Q10; CD3E
    protein binding DKK1B; HOPX; CIR1; NEFM; L3MBTL4; AKR7A3; HOMER3; CUTA; PIP4K2B; TLX1
    protein heterodimerization activity H2AFJ; PDSS1; YWHAE; TLX1; H2-Q10; SOX17; KATNA1; IL12A; CASP8; HIST1H2BH
    protein kinase binding SYK; PPP1R12B; CCNE1; E2F1; PEBP1; LIMS1; GOLGA2; TCF7L2; TELO2; KIF13B
    receptor signaling complex scaffold activity CD3G; NCK1; GRIP2A; CARD10; LRRK2; DEDD2; SPAG9A; LDLRAP1; MAPK8IP3; RGS14
    receptor signaling protein activity TRAIP; RAF1B; NSMAF; Siglece; DOK4; IL4R; ARF1; cgr2b; TGFBR1; CD19
    transmembrane signaling receptor activity FZD1; FZD3A; EMR4; CLDN4; SLC22A17; CD79A; NRXN3; OR4N4; IL11RA; ICAM1

    CD3E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD3E here. Most of them are supplied by our site. Hope this information will be useful for your research of CD3E.

    EPS8L1; NCK1; SYK; ZAP70

    Dickson, MC; Ludbrook, VJ; et al. A model of skin inflammation in humans leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development. INFLAMMATION RESEARCH 64:171-183(2015).
    Chia, LY; Walsh, NC; et al. Isolation and gene expression of haematopoietic-cell-free preparations of highly purified murine osteocytes. BONE 72:34-42(2015).

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