|Official Full Name||CD3e molecule, epsilon (CD3-TCR complex)|
|Background||The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.|
|Synonyms||CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit o; T3E; TCRE; IMD18; T-cell antigen receptor complex,|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CD3E involved in several pathways and played different roles in them. We selected most pathways CD3E participated on our site, such as Hematopoietic cell lineage, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD3E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Hematopoietic cell lineage||ITGA2B; Itgam&Itgb2; Il4ra; ITGA3; Flt3l; IL5; CD1C; ITGA1; CSF3R; CD36|
|T cell receptor signaling pathway||MAP2K2; MAPK12; GRB2; IKBKB; LCK; NFATC2; SLA1; NFKB1; RAF1; PIK3R3|
|Chagas disease (American trypanosomiasis)||CD3E; CD3D; IL10; CD3E; TRAF6; MYD88; PPP2R2D; CALR; PIK3CG; GNAI1; CXCL8|
|Measles||GSK3B; OAS1; OAS3; CCND2; EIF3H; AKT1; IFNA10; PIK3R1; IL2RG; Ifna11|
|HTLV-I infection||SRF; HLA-DOB; CD40; ELK1; WNT2; SLC25A6; Adcy4; HLA-DQB1; HRAS; PIK3R3|
|Primary i||CD8A; RAG2; PTPRC; RFXAP; AIRE; TNFRSF13B; CD40; TAP1; CD3D; RFXANK|
|nodeficiency||ZAP70; RFX5; LCK; RAG2; TAP1; UNG; BLNK; RFXAP; CD3E; CD40LG|
CD3E has several biochemical functions, for example, SH3 domain binding, T cell receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD3E itself. We selected most functions CD3E had, and list some proteins which have the same functions with CD3E. You can find most of the proteins on our site.
|SH3 domain binding||ADAM12; ARHGAP6; REPS1; ADAM10; EVLB; NCF1; MICAL1; INPP5D; ARHGAP17; CRB3|
|T cell receptor binding||EPS8L1; FYN; HLA-A; DOCK2; CD1d1; CD3G; H2-Q10; CD3E|
|protein binding||DKK1B; HOPX; CIR1; NEFM; L3MBTL4; AKR7A3; HOMER3; CUTA; PIP4K2B; TLX1|
|protein heterodimerization activity||H2AFJ; PDSS1; YWHAE; TLX1; H2-Q10; SOX17; KATNA1; IL12A; CASP8; HIST1H2BH|
|protein kinase binding||SYK; PPP1R12B; CCNE1; E2F1; PEBP1; LIMS1; GOLGA2; TCF7L2; TELO2; KIF13B|
|receptor signaling complex scaffold activity||CD3G; NCK1; GRIP2A; CARD10; LRRK2; DEDD2; SPAG9A; LDLRAP1; MAPK8IP3; RGS14|
|receptor signaling protein activity||TRAIP; RAF1B; NSMAF; Siglece; DOK4; IL4R; ARF1; cgr2b; TGFBR1; CD19|
|transmembrane signaling receptor activity||FZD1; FZD3A; EMR4; CLDN4; SLC22A17; CD79A; NRXN3; OR4N4; IL11RA; ICAM1|
CD3E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD3E here. Most of them are supplied by our site. Hope this information will be useful for your research of CD3E.
EPS8L1; NCK1; SYK; ZAP70