il12b
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  • Official Full Name
  • interleukin 12B
  • Background
  • This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
  • Synonyms
  • 40 kD Subunit; CLMF 2; CLMF; CLMF p40; CLMF2; Cytotoxic lymphocyte maturation factor 2; Cytotoxic lymphocyte maturation factor 2 p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; HGNC:5970; IL 12 subunit p40; IL 12B; IL-12 subunit p40; IL-12B; IL12 subunit p40; IL12B; IL12B_HUMAN; Interleukin 12 p40; Interleukin 12 subunit beta; Interleukin 12B; Interleukin-12 subunit beta; Interleukin12B; NK cell stimulatory factor chain 2; NKSF; NKSF2; p40; IL12 p40-Carboxyterminal end
Cat.#:IL12B-576STag:His
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep IL12B Protein (23-327 aa), His-tagged
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Cat.#:IL12B-4330STag:
Source (Host):YeastSpecies:Sheep
Product nameRecombinant Sheep IL12B Protein
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Cat.#:IL12A & IL12B-357HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A & IL12B protein
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Cat.#:IL12B-141HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human IL12B, His-tagged
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Cat.#:IL12B-145HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12B, His tagged
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Cat.#:IL12B-172HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12B, His-tagged
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Cat.#:IL12B-177HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 12B
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Cat.#:IL12B-179HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IL12B Protein, DDK-tagged
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Cat.#:IL12B-272HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12B, StrepII-tagged
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Cat.#:IL12B-29638THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12B, His-tagged
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Cat.#:IL12B-310HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12B, Fc tagged
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Cat.#:IL12B-35HTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 12B, Fc-Tagged
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Cat.#:IL12B-43HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL12B, His-tagged
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Cat.#:Il12b-750HTag:Fc
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human Il12b Protein, Fc Chimera
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Cat.#:Il12b-178MTag:N/A
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Murine Interleukin 12b
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Cat.#:Il12b-348MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il12b, Fc-tagged
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Cat.#:IL12B-435MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il12b, LEVLFQ tagged
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Cat.#:Il12b-5647MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Interleukin 12b, His-tagged
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Cat.#:Il12b-738MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il12b, Fc tagged
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Cat.#:Il12b-847MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il12b protein, His & T7-tagged
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Cat.#:Il12b-8693MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il12b, His tagged
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Cat.#:IL23A-159MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il23a & Il12b, His tagged
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Cat.#:Il12b&Il12a-748RTag:
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Rat
Product nameRecombinant Rat Il12b&Il12a
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Cat.#:Il12b&Il23a-747RTag:
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Rat
Product nameRecombinant Rat Il12b&Il23a
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Cat.#:Il12b-1104RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il12b Protein, Fc-tagged
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Cat.#:Il12b-849RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il12b protein, His & T7-tagged
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Cat.#:Il12b-86RTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Rat
Product nameRecombinant Rat Interleukin 12b
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Cat.#:Il12b-8789RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il12b, His tagged
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Cat.#:Il23a&Il12b-556RTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il23a&Il12b
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Cat.#:IL12B-614CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12B Protein, His-tagged
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Cat.#:IL12B-2230RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL12B Protein, His-tagged
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Cat.#:IL12B-03CTag:His
Source (Host):NS0Species:Canine
Product nameRecombinant Canine IL12B protein, His-tagged
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Cat.#:IL12B-845DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL12B protein, His & T7-tagged
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Cat.#:IL12B-1028RTag:His
Source (Host):HEK293Species:Rabbit
Product nameRecombinant Rabbit IL12B Protein, His-tagged
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Cat.#:IL12B-7124CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL12B
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Cat.#:IL12B&IL12A-903FTag:
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Feline
Product nameRecombinant Feline IL12B&IL12A
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Cat.#:IL12B-100ETag:
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine IL-12 p40
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Cat.#:IL12B-154MTag:His
Source (Host):HEK293Species:Marmoset
Product nameRecombinant Marmoset IL12B, Fc tagged
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Cat.#:IL12B-844CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL12B protein, His & T7-tagged
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Cat.#:IL12B-846HTag:His/T7
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse IL12B protein, His & T7-tagged
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Cat.#:IL12B-848PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL12B protein, His & GST-tagged
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Cat.#:IL12B-84STag:
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine IL-12 p40
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Cat.#:IL12B-902FTag:His
Source (Host):NSO CellsSpecies:Feline
Product nameRecombinant Feline IL12B Protein, His-tagged
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Cat.#:IL23A-162MTag:Fc
Source (Host):HEK293Species:Marmoset
Product nameRecombinant Marmoset IL23A & IL12B, His tagged
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Cat.#:Il12b-643MTag:N/A
Source (Host):S. frugiperdaSpecies:Mouse
Product nameRecombinant Mouse Interleukin 12b
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Cat.#:Il12b-644MTag:N/A
Source (Host):S. frugiperdaSpecies:Mouse
Product nameRecombinant Mouse Interleukin 12b
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Cat.#:IL12B-220HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human IL12B
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Cat.#:IL12B-233BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Interleukin 12B
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Cat.#:IL12A & IL12B-1908HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12A & IL12B cell lysate
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Cat.#:IL12B-2731HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL12B cell lysate
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Cat.#:IL12A & IL12B-1779MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
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Cat.#:IL12A & IL12B-1780MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
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Cat.#:IL12A & IL12B-1781MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
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Cat.#:IL12A & IL12B-1782MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12A & IL12B cell lysate
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Cat.#:IL12B-1101MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL12B cell lysate
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Cat.#:IL12B-1197RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat IL12B cell lysate
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Cat.#:IL12A & IL12B-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL12A & IL12B cell lysate
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Cat.#:IL12B-1000MCLTag:
Source (Host):HEK293Species:Marmoset
Product nameRecombinant Marmoset IL12B cell lysate
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Cat.#:IL12B-128HGTag:
Source (Host):Insect cellSpecies:Human
Product nameGMP Recombinant Human IL12B Protein
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Cat.#:CAB-T9002HTag:
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Anti-Human IL 12B Monoclonal Antibody
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Involved Pathway

IL12B involved in several pathways and played different roles in them. We selected most pathways IL12B participated on our site, such as Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CRFB16; TNFSF13B; CCL18; CCL23; CSF1RA; BMP7A; IFNA1; CCL6; XCR1; TNFRSF12A
Toll-like receptor signaling pathway
MAPK12B; TOLLIP; TLR4; RIPK1; IFNPHI3; CD40; NFKBIAA; TRAF3; MAPK13; CCL3
RIG-I-like receptor signaling pathway
IRF3; MAPK13; DDX3X; IFNB; MAPK12A; DDX58; CXCL10; IFNA10; TANK; IFNPHI1
Jak-STAT signaling pathway
CSH; PTPN6; IFNA1; IFNA7; SOCS6B; HRAS; IL9R; LEP; STAT1A; RAF1B
Type I diabetes mellitus
INS2; IL12A; HLA-DRA; PTPRN2; HLA-DOB; GZMB; HLA-DRB4; HLA-DQB1; HLA-DMB; CD86
Pertussis
IRF1; GNAI1; CFL2; Itgam&Itgb2; C2; C4BPB; CALM4; MAPK11; C1R; C1QA
Legionellosis
NLRC4; IL12B; RAB1B; BCL2L13; NAIP7; NFKB1; TNF; CASP9; ITGAM; Itgam&Itgb2
Leishmaniasis
IRAK4; MARCKSL1; PRKCB; HLA-DQA2; HLA-DPB1; MAPK13; IFNGR1; IL1A; NFKB1; FCGR2A
Chagas disease (American trypanosomiasis)
GNAS; GNA14; IL1B2; PIK3CB; GNAI2; IL-8; Ccl12; IL12A; PPP2R2D; PLCB1
African trypanosomiasis
HPR; PLCB3; PLCB1; APOA1; HBB-B2; TLR9; IL12A; FAS; MYD88; IL12B
Toxoplasmosis
IRGM1; MAPK11; GNAI1; PIK3R3; TYK2; PIK3R2; LAMA3; HLA-DOA; IFNGR1; XIAP
Amoebiasis
PIK3R3; GM-CSF; CXCL1; VCL; SERPINB6; IL1B; PRKACG; MUC2; CD1D; SERPINB3C
Tuberculosis
IFNA21; ATP6V0D2; RAF1; IL1A; HLA-DQA1; HLA-DMB; STAT1; HLA-DOB; LSP1; SYK
Measles
RCHY1; IFNA5; IFNA1; CD209C; IL6; HSPA1B; IL1A; STAT1; CBLB; IFNA6
Influenza A
OAS1B; MAPK12; FURIN; PABPN1L; MAP2K4; AKT2; IL12A; IL33; NXT2; MYD88
Herpes simplex infection
CDC34A; SRSF7; HNRPK; ALYREF; TRAF6; IL12B; GTF2I; TNFSF14; Hc; SRSF5B
Proteoglycans in cancer
VAV2; ELK1; PIK3R5; RPS6; RRAS2; NRAS; Casp3; WNT3A; FZD5; HCLS1
Inflammatory bowel disease (IBD)
IL12B; TGFB3; NFATC1; HLA-DRB4; HLA-DMB; Il23a; Il12b; TNF; HLA-DOB; H2-AB1; IFNGR2
Allograft rejection
FAS; CD80; CD40; HLA-DRA; IL12B; H2-AA; HLA-F; HLA-DRB4; IL4; MICA

Protein Function

IL12B has several biochemical functions, for example, contributes_to cytokine activity, cytokine receptor activity, contributes_to growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12B itself. We selected most functions IL12B had, and list some proteins which have the same functions with IL12B. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to cytokine activity
Related Protein CLCF1; CRLF1; IL12A; IL12B
Function cytokine receptor activity
Related Protein IL12RB1; CRFB16; GHR; LEPR; IL17RB; PRLRA; IL21R.2; IL20RB; CRFB6; IRX1
Function contributes_to growth factor activity
Related Protein IL12A; IL12B
Function identical protein binding
Related Protein DYNLT3; PCNA; BAIAP2; VCP; PVRL2; PTEN; SNX16; C1QL4; RAF1; DAPK1
Function interleukin-12 alpha subunit binding
Related Protein IL12BA; IL12B
Function interleukin-12 receptor binding
Related Protein JAK2; IL12A; IL12BA; IL12B
Function contributes_to interleukin-12 receptor binding
Related Protein IL12RB1; IL12B; IL23R
Function contributes_to interleukin-23 receptor binding
Related Protein Il23a; Il12b; IL12B; IL23
Function protein binding
Related Protein GALR2; COPS8; ZYX; NDUFA4; TNFSF13B; SLC19A2; GSTM4; RSPH3; RNF216; LCE3E
Function protein heterodimerization activity
Related Protein ADD2; SMAD4; NR4A2; POLE4; ALG2; KHDRBS2; BMP7A; HIST1H2AK; VEGFB; SMAD3
Function protein homodimerization activity
Related Protein VPS24; TBX1; CTBP2; NTRK2; PVRL1B; DGAT2; SDCBP; VPS4B; DDX1; PDK2

Interacting Protein

IL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12B.
IL23A; IL12A; Il23a; IL12RB1; IL12RB1

IL12B Related Articles

Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
Ovsyannikova, IG; Salk, HM; et al. Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines. IMMUNOGENETICS 66:663-669(2014).

IL12B Related Gene Family

IL