Ifng
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Official Full Name
interferon, gamma
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Overview
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009] -
Synonyms
IFNG; interferon, gamma; IFG; IFI; interferon gamma; IFN-gamma; immune interferon;
- Recombinant Proteins
- GMP Proteins
- Cell & Tissue Lysates
- Therapeutic Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Bovine
- Canine
- Cattle
- Chicken
- Cynomolgus Monkey
- Dog
- Equine
- Ferret
- Goat
- Guinea pig
- Horse
- Human
- Marmota monax (Woodchuck)
- Mouse
- Ovine
- Pig
- Porcine
- Rabbit
- Rat
- Rhesus
- Rhesus Macaque
- Sheep
- Siniperca chuatsi (Mandarin fish)
- Barley Grain
- CHO
- CHO-K1
- COS-7 cells
- E. coli
- E.coli
- HEK293
- HEK293F
- Hordeum Vulgare
- Human Cell
- Human cells
- Mammalian Cell
- Mammalian cells
- Yeast
- C
- His
- Fc
- Fc|His
- His(C
- ter)
- Flag
- GST
- hFc
- His (Fc)
- Avi
- Myc
- His|GST
- His|T7
- Met
- Myc|DDK
- N/A
- N
- Strep II
- Tag free
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- Ifng Related Articles
- Ifng Related Research Area
- Ifng Related Signal Pathway
Ifng involved in several pathways and played different roles in them. We selected most pathways Ifng participated on our site, such as Proteasome, Cytokine-cytokine receptor interaction, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ifng were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Proteasome | PSME4;PSMD11;PSME2;PSMD8;PSMD11B;PSME4B;PSMC1B;PSMA6A;PSMB6 |
Cytokine-cytokine receptor interaction | TNFRSF8;TGFB1A;IL1A;IL9R;IL19;TNFRSF17;CXCL2;IFNAR1;CCL20B |
HIF- signaling pathway | PIK3R5;TIMP1;TFRC;ANGPT4;LTBR;ENO1;EIF4E1B;CAMK2B;AKT2 |
Regulation of autophagy | INS1;Ifna11;ULK1;GABARAPA;IFNA16;BECN1;ATG16L1;IFNA1;ATG3 |
TGF-beta signaling pathway | TGFBR2;NBL1;SMAD3A;MYCB;BMPR1A;SMAD2;MAPK1;ACVR1BA;RPS6KB2 |
Osteoclast differentiation | RAC1;PIK3R2;NFKB1;TAB2;BLNK;SFPI1;SOCS3;GAB2;IKBKB |
Antigen processing and presentation | TAP2;KIR2DL3;H2-Q10;HLA-DQB1;HLA-DMB;CD8B1;KIR3DL2;KLRC1;HLA-E |
Jak-STAT signaling pathway | AKT1;STAT2;AOX3;JAK2B;IL27RA;IL24;IFNA12;PIK3R5;IL23 |
Natural killer cell mediated cytotoxicity | KLRA8;IFNA1;SHC1;Raet1a;NCR3;PPP3R1;KIR3DL2;Ifna11;HRAS |
T cell receptor signaling pathway | NFATC3;IFNG;PLCG1;CD8B1;PIK3CA;CDC42;KRAS;NFKBIA;MAP3K7 |
Type I diabetes mellitus | HLA-DPB1;HLA-DQB1;HLA-DQA2;HLA-DMA;TNF;HLA-F;IL1A;ICA1;HLA-DQA1 |
Salmonella infection | NOS2;WASLB;ROCK2A;RAB7B;ACTG1;KLC2;CCL3L3;CDC42L;ACTB1 |
Leishmaniasis | IFNGR2;CR1;HLA-DQA1;FCGR4;ITGB1;IL12B;H2-AB1;HLA-DMA;MARCKSL1 |
Chagas disease (American trypanosomiasis) | MAPK8;TGFBR1;PPP2R1B;PIK3R1;CASP8;IRAK4;PIK3CG;GNAO1;CD247 |
African trypanosomiasis | ICAM1;IFNG;PLCB1;FAS;HBA-A2;IL12B;MYD88;APOA1;LAMA4 |
Malaria | SELE;KLRC4-KLRK1;SDC1;HGF;LRP1;KLRK1;TGFB1;GYPC;IL18 |
Toxoplasmosis | LAMB1;IRAK1;HSPA1L;HLA-DRB5;LAMA5;HLA-DMB;MAPK8;IFNGR1;NFKB1 |
Amoebiasis | CD1d1;MUC2;SERPINB9;IL1R1;CXCL8;PRKCB;ACTN4;ARG2;SERPINB1 |
Tuberculosis | CLEC4M;MAPK12;CALML5;CORO1A;IL10RB;IFNA12;PMAP-36;ATP6V0D1;HLA-DRB3 |
Measles | CBLB;Ifna11;IL1B;IFNA21;TNFAIP3;IFNA7;TLR7;IFNA2;PIK3R2 |
Influenza A | NLRP3;TMPRSS2;AKT1;MAPK13;CPSF4;IFNA21;AGFG1;NLRX1;XPO1 |
Herpes simplex infection | EP300;RELA;PILRA;GLTSCR2;EEF1DA;BMA2;HLA-DRA;IRF3;C5 |
Epstein-Barr virus infection | PSMD4;PSMC4;POLR2I;YWHAG;RELA;SFPI1;PSMD7;POLR3C;HSPB1 |
Inflammatory bowel disease (IBD) | TBX21;TLR4;NFATC1;IL23R;Il4ra;HLA-DQA2;IL5;TLR5;IL21 |
Systemic lupus erythematosus | C7;FCGR3;HIST1H2AJ;HIST1H4G;HIST1H3D;HIST1H2BC;HIST1H4C;H2AFY2;HIST2H2AA4 |
Rheumatoid arthritis | Ctsl;ATP6V1G2;ATP6V0E1;MMP1A;CD86;TNFRSF11A;HLA-DMA;LTB;IFNG |
Allograft rejection | HLA-G;PRF1;HLA-DRB5;CD80;H2-AB1;IL12A;HLA-E;HLA-A;MICA |
Graft-versus-host disease | HLA-DOA;HLA-G;HLA-DQA2;H2-AA;HLA-A;KLRD1;HLA-DQA1;HLA-DOB;H2-AB1 |
Ifng has several biochemical functions, for example, cytokine activity, interferon-gamma receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ifng itself. We selected most functions Ifng had, and list some proteins which have the same functions with Ifng. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
cytokine activity | TNFSF13B;IL9;IL26;GDF15;IFNA5;FGF2;TNFSF18;HMGB1B;VSTM1 |
interferon-gamma receptor binding | IFNG1-1;IFNG1-2;DNAJA3;IFNG |
Ifng has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ifng here. Most of them are supplied by our site. Hope this information will be useful for your research of Ifng.
IFNGR1; b8_vaccw
- Q&As
- Reviews
Q&As (6)
Ask a questionIFNG plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.
The development of drugs for IFNG is currently in clinical trials, including monoclonal antibodies against IFNG receptors and inhibitors against IFNG signaling pathways.
Studies have shown that IFNG can inhibit the occurrence of muscle atrophy, but the specific mechanism is not clear.
In clinical practice, the expression level of IFNG can be measured to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen.
Yes, there are other coding variants in the IFNG gene that may have different functions and expression patterns.
Such as nutritional status, inflammation levels, etc. Yes, the expression of IFNG is affected by environmental factors, such as nutritional status, inflammation level, etc.
Customer Reviews (3)
Write a reviewIt is analyzed by X-ray crystallography or other crystallization techniques and has good crystallization properties.
Easy to attach to the surface of cells or materials.
IFNG products have a complete range of specifications for experimental designs of different sizes and needs.
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