flt3
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  • Official Full Name
  • fms-related tyrosine kinase 3
  • Background
  • This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; FLK-2; receptor-type tyrosine-protein kinase FLT3; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III
Cat.#:FLT3-1155RTag:His
Source (Host):HEK293Species:Rhesus Monkey
Product nameRecombinant Rhesus Monkey FLT3 Protein, His-tagged
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Cat.#:FLT3-2340HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT3 Protein, MYC/DDK-tagged
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Cat.#:FLT3-4370HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human FLT3 Protein, GST-tagged
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Cat.#:FLT3-4371HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FLT3 Protein, GST-tagged
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Cat.#:FLT3-319HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FLT3, GST-tagged, Active
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Cat.#:FLT3-494HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 3
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Cat.#:FLT3-04HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLT3
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Cat.#:FLT3-12937HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLT3, GST-tagged
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Cat.#:FLT3-140HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Fms-related Tyrosine Kinase 3, Fc Chimera
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Cat.#:FLT3-1550HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human FLT3, Active
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Cat.#:FLT3-155HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human FLT3, Fc Chimera
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Cat.#:FLT3-157HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT3 protein, DDK/His-tagged
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Cat.#:FLT3-158HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FLT3 protein, DDK-tagged
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Cat.#:FLT3-185HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FLT3 protein
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Cat.#:FLT3-208HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human FLT3
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Cat.#:FLT3-2243HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT3, His tagged
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Cat.#:FLT3-2244HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT3, His tagged
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Cat.#:FLT3-259HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FLT3 (D835Y), GST-tagged
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Cat.#:FLT3-28340THTag:His
Source (Host):Species:Human
Product nameRecombinant Human FLT3, His-tagged
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Cat.#:FLT3-28342THTag:
Source (Host):Species:Human
Product nameRecombinant Human FLT3
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Cat.#:FLT3-28413THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLT3
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Cat.#:FLT3-28417THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human FLT3, Fc-tagged
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Cat.#:FLT3-48HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human FLT3 protein, Flag-tagged, Biotinylated
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Cat.#:FLT3-4902HTag:GST/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FLT3 protein, GST/His-tagged
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Cat.#:FLT3-545HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 3, His-tagged
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Cat.#:FLT3-763HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FLT3 protein, His & T7-tagged
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Cat.#:VCL-230HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VCL protein
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Cat.#:FLT3-303MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FLT3, His-tagged
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Cat.#:Flt3-500MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse FMS-like Tyrosine Kinase 3
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Cat.#:Flt3-764MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Flt3 protein, His & T7-tagged
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Cat.#:FLT3-1567RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FLT3 Protein
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Cat.#:FLT3-1568RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FLT3 Protein, hIgG1-tagged
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Cat.#:FLT3-1569RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FLT3 Protein, hIgG4-tagged
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Cat.#:FLT3-1016HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 3, GST-tagged
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Cat.#:FLT3-1225HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 3
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Cat.#:FLT3-1226HTag:N/A
Source (Host):Hordeum vulgare (barley grain)Species:Human
Product nameRecombinant Human Fms-Related Tyrosine Kinase 3
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Cat.#:FLT3-688HTag:GST
Source (Host):S. frugiperdaSpecies:Human
Product nameRecombinant Human FLT3, GST-His
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Cat.#:FLT3-1154RTag:N/A
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Macaque Fms-Related Tyrosine Kinase 3
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Cat.#:FLT3-2561HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FLT3 cell lysate
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Cat.#:FLT3-970MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FLT3 cell lysate
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Cat.#:Kit-1592Tag:
Source (Host):Species:
Product nameFlt3 ActivityAssay Kit
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Cat.#:Kit-1593Tag:
Source (Host):Species:
Product nameFlt3 Activity Assay Kit
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Involved Pathway

FLT3 involved in several pathways and played different roles in them. We selected most pathways FLT3 participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
LTBR; KIT; IFNA3; IL17RB; TNFRSF9A; CCR8L; CCL21B; IL1A; LTB; IFNA5
Hematopoietic cell lineage
ANPEP; CD19; GP9; ITGAM; CD3E; CR1; IL6; KIT; MME; Kitl
Pathways in cancer
FGF19; FGF7; NCOA4; LAMC2; PIK3CD; ITGA2B; ROCK1; WNT5A; CTBP2; NFKB1
Transcriptional misregulation in cancer
MYCN; NCOR1; PFTK1; H3F3C; TMPRSS2; PRCC; CCNA1; WT1; HIST2H3C2; ETV4
Acute myeloid leukemia
LEF1; MYC; PIK3CD; AKT3; PML; CCND1; PIK3CB; NRAS; PIK3R2; CCNA1
Central carbon metabolism in cancer
PIK3R1; HK3; RAF1; PKM; FGFR3; SIRT6; SIRT3; MET; IDH1; FGFR1

Protein Function

FLT3 has several biochemical functions, for example, ATP binding, cytokine receptor activity, phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT3 itself. We selected most functions FLT3 had, and list some proteins which have the same functions with FLT3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CNTN1B; FARS2; CIT; UBE2W; SRPK3; PRKG2; CDC42BPB; BMX; OAS2; ULK3
Function cytokine receptor activity
Related Protein IL28RA; LIFRB; IL12RB2; F3; CRFB16; GHRA; IL13RA2; CRFB6; CRFB17; LEPR
Function phosphatidylinositol 3-kinase binding
Related Protein CALM2; CORO1A; PDGFRB; BECN1; HCST; LCK; IGF1RA; TYRO3; JAK2; CALM3
Function protein binding
Related Protein QKI; HBP1; MSLN; RXFP4; ARHGAP5; UBE2H; METTL1; CDX1; DNAJC15; TNPO1
Function protein homodimerization activity
Related Protein HIF1AN; ASNSD1; SYNE1; PRMT2; NLGN4X; KCNH2; CHMP1A; COQ9; ODC1; PLEK
Function transmembrane receptor protein tyrosine kinase activity
Related Protein TYRO3; RET; INSRA; INSRB; EPHB3A; EPHB2B; CADM2B; KIT; FGFR1A; MERTK
Function vascular endothelial growth factor-activated receptor activity
Related Protein KDR; NRP1B; FLT4; PDGFRA; NRP1A; NRP2A; NRP2; NRP2B; FLT3; FLT1

Interacting Protein

FLT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT3.
SYK

FLT3 Related Articles

Kato, T; Sakata-Yanagimoto, M; et al. Hes1 suppresses acute myeloid leukemia development through FLT3 repression. LEUKEMIA 29:576-585(2015).
Nocturne, G; Mariette, X; et al. Sjogren Syndrome-associated lymphomas: an update on pathogenesis and management. BRITISH JOURNAL OF HAEMATOLOGY 168:317-327(2015).