FLT3 Protein, fms-related tyrosine kinase 3

FLT3

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FLT3

Official Full Name fms-related tyrosine kinase 3
Background This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]
Synonyms FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; FLK-2; receptor-type tyrosine-protein kinase FLT3; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III
    • Species :
    • Human
    • Mouse
    • Rhesus
    • Rhesus monkey
    • Source :
    • E.coli
    • E.coli-derived, PGEX-4T
    • HEK293
    • Hordeum Vulgare
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Nicotiana Benthamiana
    • NS0
    • NSO
    • S.frugiperda
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • DDK
    • His
    • Fc
    • Fc Chimera
    • Flag
    • GST
    • hIgG1
    • hIgG4
    • T7
    • His-Avi
    • Human
    • IgG1
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rhesus Monkey FLT3-1155R Recombinant Rhesus Monkey FLT3 Protein, His-tagged HEK293 His
    Human FLT3-05H Recombinant Human FLT3 protein, Fc-tagged HEK293 Human/IgG1/Fc
    Human FLT3-088H Recombinant Human FLT3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human FLT3-107H Recombinant Human FLT3 protein, His-Avi-tagged HEK293 His-Avi
    Human FLT3-04H Recombinant Human FLT3 E.coli-derived, PGEX-4T N/A
    Human FLT3-1016H Recombinant Human Fms-Related Tyrosine Kinase 3, GST-tagged Sf9 Insect Cell GST
    Human FLT3-1225H Recombinant Human Fms-Related Tyrosine Kinase 3 HEK293 N/A
    Human FLT3-1226H Recombinant Human Fms-Related Tyrosine Kinase 3 Hordeum Vulgare N/A
    Human FLT3-12937H Recombinant Human FLT3, GST-tagged E.coli GST
    Human FLT3-140H Recombinant Human Fms-related Tyrosine Kinase 3, Fc Chimera HEK293 Fc
    Human FLT3-1550H Recombinant human FLT3, Active Nicotiana Benthamiana N/A
    Human FLT3-155H Recombinant Human FLT3, Fc Chimera NS0 Fc Chimera
    Human FLT3-157H Recombinant Human FLT3 protein, DDK/His-tagged HEK293 DDK/His
    Human FLT3-158H Recombinant Human FLT3 protein, DDK-tagged Insect Cell DDK
    Human FLT3-185H Recombinant Human FLT3 protein Insect Cell N/A
    Human FLT3-208H Recombinant Human FLT3 Mammalian Cell His
    Human FLT3-2243H Recombinant Human FLT3, His tagged Human Cell His
    Human FLT3-2340H Recombinant Human FLT3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human FLT3-2561HCL Recombinant Human FLT3 cell lysate Human Cell N/A
    Human FLT3-259H Recombinant Human FLT3 (D835Y), GST-tagged Sf9 Insect Cell GST
    Human FLT3-28340TH Recombinant Human FLT3, His-tagged His
    Human FLT3-28342TH Recombinant Human FLT3 N/A
    Human FLT3-28413TH Recombinant Human FLT3 E.coli N/A
    Human FLT3-28417TH Recombinant Human FLT3 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human FLT3-319H Recombinant Human FLT3, GST-tagged, Active Sf9 Insect Cell GST
    Human FLT3-4370H Recombinant Human FLT3 Protein, GST-tagged Insect Cell GST
    Human FLT3-4371H Recombinant Human FLT3 Protein, GST-tagged Wheat Germ GST
    Human FLT3-48H Recombinant Human FLT3 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human FLT3-4902H Recombinant Human FLT3 protein, GST/His-tagged Insect Cell GST/His
    Human FLT3-494H Recombinant Human Fms-related Tyrosine Kinase 3 NSO N/A
    Human FLT3-545H Recombinant Human Fms-Related Tyrosine Kinase 3, His-tagged Sf9 Insect Cell His
    Human FLT3-688H Recombinant Human FLT3, GST-His S.frugiperda GST
    Human FLT3-763H Recombinant Human FLT3 protein, His & T7-tagged E.coli His/T7
    Human VCL-230H Recombinant Human VCL protein E.coli N/A
    Mouse FLT3-303M Recombinant Mouse FLT3, His-tagged Human Cell His
    Mouse Flt3-500M Recombinant Mouse FMS-like Tyrosine Kinase 3 NSO N/A
    Mouse Flt3-764M Recombinant Mouse Flt3 protein, His & T7-tagged E.coli His/T7
    Mouse FLT3-970MCL Recombinant Mouse FLT3 cell lysate Human Cell N/A
    Rhesus FLT3-1154R Recombinant Rhesus FLT3 protein E.coli N/A
    Rhesus monkey FLT3-1567R Recombinant Rhesus Monkey FLT3 Protein HEK293 N/A
    Rhesus monkey FLT3-1568R Recombinant Rhesus Monkey FLT3 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey FLT3-1569R Recombinant Rhesus Monkey FLT3 Protein, hIgG4-tagged HEK293 hIgG4
    Kit-1592 Flt3 ActivityAssay Kit N/A
    Kit-1593 Flt3 Activity Assay Kit N/A

    FLT3 involved in several pathways and played different roles in them. We selected most pathways FLT3 participated on our site, such as Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL12A; IL4; VEGFA; NGFRB; CD40LG; CCR3; LEPR; TNFRSF1B; CNTFR; TNFRSF21
    Hematopoietic cell lineage CD34; GP1BA; ITGA2B; CD3D; CD1C; CSF3; IL4; HLA-DRB4; HLA-DRB3; CSF3R
    Pathways in cancer CASP9; SMO; CBLC; LPAR4; HSP90AA1; Fgf15; Ar; CTBP2; MMP1A; AXIN1
    Transcriptional misregulation in cancer DDX5; PBX3; ITGB7; IGF1R; NGFR; MMP9; ERG; MEIS1; BCL2A1A; RUNX1
    Acute myeloid leukemia ARAF; RARA; RPS6KB1; PIK3CG; NFKB1; PIK3R3; MAP2K1; LEF1; IKBKB; TCF7
    Central carbon metabolism in cancer PFKL; PKM; HK1; HK2; KIT; G6PDX; KRAS; PDGFRA; GLS; GLS2

    FLT3 has several biochemical functions, for example, ATP binding, cytokine receptor activity, phosphatidylinositol 3-kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLT3 itself. We selected most functions FLT3 had, and list some proteins which have the same functions with FLT3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PSMC6; PRKCHA; MYH9A; P2RY1; SCYL2; HNRNPU; ERBB4A; NEK10; DCLK3; TNNI3K
    cytokine receptor activity Ifnlr1; CD74; IL21R.2; Il6ra; IL11RA; IL12RB2; IL20RB; IL2RGB; F3B; CRFB15
    phosphatidylinositol 3-kinase binding PIK3R1; JAK2; IGF1RB; ATP1A1; INSRR; INSR; IRS2; HCST; CALM2; IGF1R
    protein binding PIR; ELOVL6; RBKS; STARD13; ARHGEF7; SNX17; IFT43; RAB2A; RUVBL1; NCAPH2
    protein homodimerization activity MAP3K13; ACTN3; CAMK2A; CTBP2; PPP2R4; RRAGA; ATF3; XDH; NR2C1; IRAK1
    transmembrane receptor protein tyrosine kinase activity TEK; ERBB4A; LTK; AXL; ERBB4; INSRA; EPHB4; ERBB3B; INSRR; IGF1RA
    vascular endothelial growth factor-activated receptor activity NRP1A; FLT1; FLT4; NRP1B; KDR; NRP1; NRP2A; NRP2B; PDGFRA; NRP2

    FLT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FLT3.

    SYK

    Kato, T; Sakata-Yanagimoto, M; et al. Hes1 suppresses acute myeloid leukemia development through FLT3 repression. LEUKEMIA 29:576-585(2015).
    Nocturne, G; Mariette, X; et al. Sjogren Syndrome-associated lymphomas: an update on pathogenesis and management. BRITISH JOURNAL OF HAEMATOLOGY 168:317-327(2015).

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