il13
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  • Official Full Name
  • interleukin 13
  • Background
  • This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
  • Synonyms
  • ALRH; BHR1; P600; IL-13; interleukin-13; allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma); NC30; Tralokinumab; 1044515-88-9; Lebrikizumab; 953400-68-5; Anrukinzumab (= IMA-638); 910649-32-0
Cat.#:IL13-4350RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit IL13 Protein
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Cat.#:IL13-4328ZTag:
Source (Host):YeastSpecies:Zebrafish
Product nameRecombinant Zebrafish IL13 Protein
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Cat.#:IL13-481HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 13
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Cat.#:IL13-124HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL13 protein
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Cat.#:IL13-1251HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL13
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Cat.#:IL13-14149HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL13, His-tagged
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Cat.#:IL13-147HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL13, Fc tagged
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Cat.#:IL13-16HTag:His/Biotin
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL13, His-Biotin-tagged
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Cat.#:IL13-22HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-13
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Cat.#:IL13-28497THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL13
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Cat.#:IL13-287HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL13, StrepII-tagged
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Cat.#:IL13-29107THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL13
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Cat.#:IL13-335HTag:His/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL13 Protein, His/DDK-tagged
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Cat.#:IL13-365HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL13 protein, Fc-tagged
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Cat.#:IL13-370HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL13, None tagged
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Cat.#:IL13-44HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 13, His-tagged
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Cat.#:IL13-50HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 13, MIgG2a Fc-tagged
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Cat.#:IL13-52HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 13, HIgG1 Fc-tagged
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Cat.#:IL13-53HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 13, HIgG1 Fc-tagged, mutant
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Cat.#:IL13-856HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL13 protein, His & T7-tagged
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Cat.#:Il13-16MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il13
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Cat.#:IL13-60MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IL-13
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Cat.#:Il13-857MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il13 protein, His-tagged
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Cat.#:IL13-3026RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL13 Protein
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Cat.#:Il13-580RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il13
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Cat.#:Il13-858RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il13 protein, His & T7-tagged
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Cat.#:IL13-308CTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL13, None tagged
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Cat.#:IL13-373CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL13, His tagged
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Cat.#:IL13-2231RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL13 Protein, His-tagged
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Cat.#:IL13-542RTag:
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL13
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Cat.#:IL13-62CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine IL-13
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Cat.#:IL13-855DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL13 protein, His & T7-tagged
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Cat.#:IL13-4154CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL13
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Cat.#:IL13-58CTag:
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken IL-13
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Cat.#:IL13-7888ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL13
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Cat.#:Il13-415CTag:His
Source (Host):CHO cellsSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Il13, His-tagged
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Cat.#:IL13-854CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL13 protein, His & GST-tagged
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Cat.#:IL13-328HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL13
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Cat.#:Il13-629MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 13
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Cat.#:IL13-165HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 13, Variant
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Cat.#:Il13-87RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 13
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Cat.#:IL13-146RTag:N/A
Source (Host):CHOSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Interleukin 13
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Cat.#:IL13-234BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Interleukin 13
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Cat.#:IL13-252ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine Interleukin 13
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Cat.#:IL13-262STag:N/A
Source (Host):YeastSpecies:Pig
Product nameRecombinant Swine Interleukin 13
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Cat.#:IL13-001HCLTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL13 cell lysate
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Cat.#:IL13-2922HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL13 cell lysate
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Cat.#:IL13-1336MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL13 cell lysate
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Cat.#:IL13-1894CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL13 cell lysate
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Cat.#:IL13-4328HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL12A protein
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Cat.#:IL13-138HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-13 (rDNA derived) Reference standard
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Cat.#:IL13-P041HTag:
Source (Host):Species:Human
Product nameRecombinant Human IL13 therapeutic protein
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Cat.#:CSC-P0227Tag:
Source (Host):Species:
Product nameAnti-Human IL13 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0228Tag:
Source (Host):Species:
Product nameAnti-Human IL13 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0229Tag:
Source (Host):Species:
Product nameAnti-Human IL13 scFv Stable Cell Line-CHO
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Cat.#:CSC-P0440Tag:
Source (Host):Species:
Product nameAnti-Human ITGA3 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0441Tag:
Source (Host):Species:
Product nameAnti-Human ITGA3 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0442Tag:
Source (Host):Species:
Product nameAnti-Human ITGA3 scFv Stable Cell Line-CHO
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Involved Pathway

IL13 involved in several pathways and played different roles in them. We selected most pathways IL13 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Fc epsilon RI signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL13 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFN-a; TNFRSF9A; VEGFB; CCL19B; IL12RB1; CCL8; IL15RA; IFNK; TNFRSF13B; CCL17
Jak-STAT signaling pathway
AKT2; IL6R; IL23; IL20RA; PIK3R5; GHR; CISH; PTPN2A; CTF1; IL10RB
Fc epsilon RI signaling pathway
MAPK12; GM-CSF; MAP2K1; LCP2; IL13; HRAS; PLA2G4C; RAC3; MAPK3; PLA2G4D
Measles
TLR7; IFNA1; CD3E; CD3D; IL12A; cgr2b; IRF7; Cd209g; Fasl; IFNA16; EIF2AK3
Asthma
HLA-DMA; HLA-DOA; H2-AA; HLA-DRB4; H2-AB1; HLA-DPA1; HLA-DRB1; HLA-DMB; CD40; IL5
Inflammatory bowel disease (IBD)
HLA-DPA1; H2-AA; HLA-DRA; Il23a; TLR4; IL17F; H2-AB1; IL18RAP; IL18R1; HLA-DOA

Protein Function

IL13 has several biochemical functions, for example, cytokine activity, interleukin-13 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL13 itself. We selected most functions IL13 had, and list some proteins which have the same functions with IL13. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein GDF10B; IL17A; IFNA13; GM13278; TNFSF10; SCG2; BMP8A; IL26; IL11; GDF7
Function interleukin-13 receptor binding
Related Protein IL13
Function protein binding
Related Protein PSMB9; KCNG4; PPM1B; MRFAP1L1; COPS7B; DDR2; SEC63; TSSC4; DIEXF; ITGA1

Interacting Protein

IL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL13.
IL13RA1

IL13 Related Articles

Tripp, C; Campbell, A; et al. THE CHARACTERIZATION OF RPC4046, A NOVEL ANTI-IL13 MONOCLONAL ANTIBODY THAT BLOCKS BINDING TO IL-13 RECEPTOR alpha 1 AND alpha 2 IN DEVELOPMENT FOR EOSINOPHILIC ESOPHAGITIS: RESULTS OF A FIRST-IN-HUMAN STUDY.. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 113:A104-A105(2014).
Wilson, AD; et al. Immune responses to ectoparasites of horses, with a focus on insect bite hypersensitivity. PARASITE IMMUNOLOGY 36:558-570(2014).

IL13 Related Gene Family

IL