IL13

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IL13

Official Full Name interleukin 13
Background This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Synonyms ALRH; BHR1; P600; IL-13; interleukin-13; allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma); NC30; Tralokinumab; 1044515-88-9; Lebrikizumab; 953400-68-5; Anrukinzumab (= IMA-638); 910649-32-0
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Chicken
    • Cotton Rat
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Mammalian Cell
    • Rat
    • Yeast
    • Tag :
    • APC
    • Fc
    • HIgG1 Fc-tagged
    • His
    • Biotin
    • DDK
    • GST
    • T7
    • His-Avi
    • human
    • IgG1
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Il13-087M Recombinant Mouse Il13 Protein E.coli
    Mouse Il13-088M Recombinant Mouse Il13 Protein E.coli
    Mouse Il13-089M Recombinant Mouse Il13 Protein E.coli
    Mouse Il13-090M Recombinant Mouse Il13 Protein E.coli
    Human IL13-229H Recombinant Human IL13 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL13-293H Recombinant Human IL13 protein, His-tagged HEK293 His
    Human IL13-3589H Recombinant Human IL13 protein, His-tagged HEK293 His
    Human IL13-432HG GMP Recombinant Human IL13 protein, His-tagged HEK293 His
    Human IL13-519HB Recombinant Human IL13 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL13-589H Recombinant Human IL13 protein, His-Avi-tagged HEK293 His-Avi
    Human DMABT-H19232 Rat Anti-IL13 Monoclonal Antibody Rat APC
    Human IL13-001HCL Recombinant Human IL13 cell lysate CHO N/A
    Human IL13-124H Recombinant Human IL13 protein E.coli N/A
    Human IL13-1251H Recombinant Human IL13 E.coli N/A
    Human IL13-138H Human Interleukin-13 (rDNA derived) Reference standard N/A
    Human IL13-14149H Recombinant Human IL13, His-tagged E.coli His
    Human IL13-147H Recombinant Human IL13, Fc tagged Human Cell Fc
    Human IL13-165H Recombinant Human IL13 protein E.coli N/A
    Human IL13-16H Recombinant Human IL13, His-Biotin-tagged E.coli His/Biotin
    Human IL13-22H Recombinant Human IL13 protein E.coli N/A
    Human IL13-28497TH Recombinant Human IL13 E.coli N/A
    Human IL13-287H Recombinant Human IL13, StrepII-tagged Human Cell Strep II
    Human IL13-29107TH Recombinant Human IL13 E.coli N/A
    Human IL13-2922HCL Recombinant Human IL13 cell lysate Human Cell N/A
    Human IL13-328H Recombinant Human IL13 Human N/A
    Human IL13-335H Recombinant Human IL13 Protein, His/DDK-tagged HEK293 His/DDK
    Human IL13-365H Recombinant Human IL13 protein, Fc-tagged HEK293 Fc
    Human IL13-370H Recombinant Human IL13, None tagged CHO N/A
    Human IL13-4328HG GMP Recombinant Human IL12A protein E.coli N/A
    Human IL13-44H Recombinant Human Interleukin 13, His-tagged E.coli His
    Human IL13-481H Recombinant Human Interleukin 13 E.coli N/A
    Human IL13-50H Recombinant Human Interleukin 13, MIgG2a Fc-tagged CHO Fc
    Human IL13-52H Recombinant Human Interleukin 13, HIgG1 Fc-tagged HEK293 HIgG1 Fc-tagged
    Human IL13-53H Recombinant Human Interleukin 13, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL13-856H Recombinant Human IL13 protein, His & T7-tagged E.coli His/T7
    Human IL13-P041H Recombinant Human IL13 therapeutic protein N/A
    Mouse IL13-1336MCL Recombinant Mouse IL13 cell lysate Human Cell N/A
    Mouse Il13-16M Recombinant Mouse Il13 Human Cell N/A
    Mouse IL13-60M Recombinant Mouse IL-13 Yeast N/A
    Mouse Il13-629M Recombinant Mouse Il13 protein E.coli N/A
    Mouse Il13-857M Recombinant Mouse Il13 protein, His-tagged E.coli His
    Rat IL13-3026R Recombinant Rat IL13 Protein Mammalian Cell His
    Rat Il13-580R Recombinant Rat Il13 protein E.coli N/A
    Rat Il13-858R Recombinant Rat Il13 protein, His & T7-tagged E.coli His/T7
    Rat Il13-87R Recombinant Rat Il13 protein E.coli N/A
    Cynomolgus Monkey IL13-1894CCL Recombinant Cynomolgus IL13 cell lysate Human Cell N/A
    Cynomolgus Monkey IL13-308C Recombinant Cynomolgus IL13, None tagged Human Cell N/A
    Cynomolgus Monkey IL13-373C Recombinant Cynomolgus IL13, His tagged Human Cell His
    Rhesus Macaque IL13-146R Recombinant Rhesus Interleukin 13 CHO N/A
    Rhesus Macaque IL13-2231R Recombinant Rhesus monkey IL13 Protein, His-tagged Mammalian Cell His
    Rhesus IL13-542R Recombinant Rhesus IL13 protein E.coli N/A
    Canine IL13-62C Recombinant Canine IL-13 Yeast N/A
    Dog IL13-855D Recombinant Dog IL13 protein, His & T7-tagged E.coli His/T7
    Bovine IL13-234B Recombinant Bovine Interleukin 13 Yeast N/A
    Chicken IL13-4154C Recombinant Chicken IL13 Mammalian Cell His
    Rabbit IL13-4350R Recombinant Rabbit IL13 Protein Yeast N/A
    Chicken IL13-58C Recombinant Chicken IL-13 Yeast N/A
    Zebrafish IL13-4328Z Recombinant Zebrafish IL13 Protein Yeast N/A
    Zebrafish IL13-7888Z Recombinant Zebrafish IL13 Mammalian Cell His
    Equine IL13-252E Recombinant Equine Interleukin 13 Yeast N/A
    Pig IL13-262S Recombinant Swine Interleukin 13 Yeast N/A
    Cotton Rat Il13-415C Recombinant Cotton Rat Il13, His-tagged CHO His
    Cattle IL13-854C Recombinant Cattle IL13 protein, His & GST-tagged E.coli His/GST

    IL13 involved in several pathways and played different roles in them. We selected most pathways IL13 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Fc epsilon RI signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction PPBP; IFNA8; IL22RA2; IL3; IFNGR2; CCL16; LTA; IL-8; ACVR2AA; IFNGR1
    Jak-STAT signaling pathway STAM; SOCS4; IL22RA2; SOCS6B; PIAS4; SOCS5; CNTFR; STAT1B; IL22RA1; GHR
    Fc epsilon RI signaling pathway GAB2; PLCG1; RAC3; MAPK13; LCP2; MAPK12; MAPK3; PDPK1; PIK3CB; LYN
    Measles IFNAR2; PIK3CG; IRAK4; PIK3R2; STAT1; TNFRSF10B; HSPA1L; HSPA2; TLR4; OAS3
    Asthma HLA-DRB3; HLA-DMB; IL3; IL4; IL13; IL9; HLA-DMA; HLA-DRB1; H2-AA; MS4A2
    Inflammatory bowel disease (IBD) TLR2; IL12A; NFATC1; Il23a; IL12RB2; HLA-DQA2; IFNG; IL13; RORC; TLR4

    IL13 has several biochemical functions, for example, cytokine activity, interleukin-13 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL13 itself. We selected most functions IL13 had, and list some proteins which have the same functions with IL13. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity IFNA16; TNFSF14; IL28A; GM13288; IFNG1-2; VSTM1; GDF9; TNF; IFNPHI4; IL24
    interleukin-13 receptor binding IL13
    protein binding CUL4A; RBM22; AVPR1A; UBE2D4; ITM2B; TRIM15; CLOCKA; GINS2; CEP57; HEMK1

    IL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL13.

    IL13RA1

    Tripp, C; Campbell, A; et al. THE CHARACTERIZATION OF RPC4046, A NOVEL ANTI-IL13 MONOCLONAL ANTIBODY THAT BLOCKS BINDING TO IL-13 RECEPTOR alpha 1 AND alpha 2 IN DEVELOPMENT FOR EOSINOPHILIC ESOPHAGITIS: RESULTS OF A FIRST-IN-HUMAN STUDY.. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 113:A104-A105(2014).
    Wilson, AD; et al. Immune responses to ectoparasites of horses, with a focus on insect bite hypersensitivity. PARASITE IMMUNOLOGY 36:558-570(2014).

    IL

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