il1a
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  • Official Full Name
  • interleukin 1, alpha
  • Background
  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
  • Synonyms
  • BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1; IL 1A; IL-1 alpha; Il-1a; IL1 ALPHA; IL1; IL1A; IL1A_HUMAN; IL1F1; ilia; Interleukin 1 alpha precursor; Interleukin-1 alpha; Interleukin1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha; Prointerleukin 1 alpha; IL1-ALPHA
Cat.#:IL1A-2036HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1A Protein, His-tagged
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Cat.#:IL1A-577RTag:His-SUMO
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Macaque IL1A Protein (113-271 aa), His-SUMO-tagged
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Cat.#:IL1A-4318CTag:
Source (Host):YeastSpecies:Caprine
Product nameRecombinant Caprine IL1A Protein
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Cat.#:IL1A-5432PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig Interleukin 1, Alpha
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Cat.#:IL1A-131HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1A protein
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Cat.#:IL1A-14166HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1A, GST-tagged
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Cat.#:IL1A-155HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1A, None tagged
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Cat.#:Il1A-26382HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il1A, HIgG1 Fc-tagged, mutant
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Cat.#:Il1A-26682HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Il1A, HIgG1 Fc-tagged
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Cat.#:IL1A-36682HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL1A, MIgG2a Fc-tagged
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Cat.#:IL1A-501HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant human IL1A
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Cat.#:IL1A-625HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1A protein, His & T7-tagged
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Cat.#:Il1a-306MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1a, None tagged
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Cat.#:Il1a-545MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1a
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Cat.#:Il1a-627MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il1a protein, His & T7-tagged
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Cat.#:IL1a-640MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse interleukin 1, alpha, His-tagged
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Cat.#:IL1A-8134MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IL1A Protein
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Cat.#:IL1a-92MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IL-1 alpha
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Cat.#:IL1A-3032RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL1A Protein
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Cat.#:Il1a-573RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il1a
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Cat.#:Il1a-630RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il1a protein, His & T7-tagged
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Cat.#:Il1a-75RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il1a protein, His-tagged
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Cat.#:IL1A-2238RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL1A Protein, His-tagged
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Cat.#:IL1a-46CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine IL-1 alpha
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Cat.#:IL1A-620DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL1A protein, His-tagged
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Cat.#:IL1A-621DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL1A protein, His & T7-tagged
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Cat.#:IL1A-631RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL1A protein, His-tagged
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Cat.#:IL1A-207ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine IL1A
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Cat.#:Il1a-380CTag:
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Il1a
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Cat.#:IL1A-619CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL1A protein, His-tagged
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Cat.#:IL1A-622CTag:His
Source (Host):E. coliSpecies:Caprine (Goat)
Product nameRecombinant Caprine (Goat) IL1A protein, His-tagged
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Cat.#:IL1A-623HTag:His
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse IL1A protein, His-tagged
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Cat.#:Il1a-624GTag:His/S
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Il1a protein, His & S-tagged
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Cat.#:IL1A-629PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL1A protein, His-tagged
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Cat.#:IL1A-337HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL1A
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Cat.#:IL1A-01HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-1 alpha
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Cat.#:IL1A-109HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 1, Alpha, Fc Chimera
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Cat.#:IL1A-134HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 1, Alpha, His-tagged
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Cat.#:Il1a-03MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin-1 Alpha
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Cat.#:Il1a-92RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 1 Alpha
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Cat.#:IL1α-81PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine Interleukin-1 alpha
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Cat.#:IL1A-2911HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL1A cell lysate
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Cat.#:IL1A-4315HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL1A protein
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Cat.#:IL1A-85HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-1 alpha (rDNA derived) Reference standard
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Cat.#:Il1a-134MTag:
Source (Host):Species:Mouse
Product nameMouse Interleukin-1 alpha (rDNA derived) Reference standard
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Involved Pathway

Il1a involved in several pathways and played different roles in them. We selected most pathways Il1a participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
AKT3A; MAP4K1; GADD45AB; CDC25B; MAPKAPK2; TAOK2; MAPK4; GADD45B; RRAS; CACNA1H
Cytokine-cytokine receptor interaction
IL1R2; CRFB16; GM2506; VEGFAA; PRLR; IL2RGB; LIF; CXCR5; CCL22; CCL19
Apoptosis
IRAK3; PRKACA; PPP3CC; HIST1H1E; BIDA; PIK3R2; Fasl; PRKACBB; PIK3R1; Gzmg
Osteoclast differentiation
SIRPB1; MAPK8; RELB; TGFB1; LILRA5; SPI1; SFPI1; TGFB2; SQSTM1; TEC
Hematopoietic cell lineage
IL1R1; GM-CSF; Il4ra; FLT3; GP1BA; THPO; Flt3l; CD44; CD9; CD2
Non-alcoholic fatty liver disease (NAFLD)
NDUFS1; SDHA; PRKAG2; NDUFAB1; UQCRH; BID; PIK3R2; NDUFA8; UQCRFS1; NDUFA3
Type I diabetes mellitus
HLA-DOA; H2-AA; TNF; HLA-DOB; HLA-DMB; HLA-DRB3; IL1A; GZMB; PTPRN; LTA
Prion diseases
STIP1; MAP2K1; NOTCH1; C9; Hc; PRKACB; FYN; BAX; C5; C7
Salmonella infection
CCL3L3; MAPK8A; DYNC2H1; IL18; CDC42L; CCL3L1; IL8L1; RAB7; KLC4; RHOG
Pertussis
ITGB2L; CD14; C1QA; IL-8; CASP7; C5; C4BP; C1QB; CFL2; MAPK3
Leishmaniasis
CR1; ELK1; IFNGR2; PRKCB; IFNG; HLA-DPA1; HLA-DQA1; MAPK13; HLA-DRB5; ITGB2
Tuberculosis
HLA-DRA; IFNA21; HSPD1; BCL10; TLR1; ATP6V0A4; HSPA9; SPHK2; CASP9; HLA-DOB
Measles
IFNA8; DOK1; CCND2; HSPA1L; IL2RG; IFNA21; STAT2; IFNAR2; IL4; BBC3
Influenza A
NFKBIA; EP300; MAPK10; NFKBIB; RELA; IL-8; HLA-DOB; ICAM1; IFNA14; MAPK9
Inflammatory bowel disease (IBD)
HLA-DQA2; Il23a; Il12b; RORA; IL1B; RELA; HLA-DRA; HLA-DRB5; HLA-DRB4; IL18R1; STAT3
Rheumatoid arthritis
Il23a; Il12b; IL6; IL18; TNFSF11; ATP6V0E2; TNFSF13; Ccl12; CCL3L1; Ctsl; ATP6V1E1
Graft-versus-host disease
FASLG; HLA-G; HLA-DPB1; IL6; IL1B; HLA-DMB; CD80; PRF1; HLA-DRB4; HLA-F

Protein Function

Il1a has several biochemical functions, for example, copper ion binding, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1a itself. We selected most functions Il1a had, and list some proteins which have the same functions with Il1a. You can find most of the proteins on our site.
Function
Related Protein
Function copper ion binding
Related Protein S100A13; AOC2; PRNP; ATP7B; P2RX4; SOD1; RNF7; POLR1B; AOC3; MOXD1L
Function cytokine activity
Related Protein VEGFA; IL17A/F3; CCL20B; GDF2; IL24; CCL20A.3; TNFSF11; IFNE; GDF6; IL22
Function interleukin-1 receptor binding
Related Protein IL1RN; IL1RAP; TRIP6; IL37; IL36A; IL1F10; IL36RN; IRAK4; IL36B; IL1A
Function protein binding
Related Protein SOCS7; MARVELD3; GPS1; CCDC92; TSPAN15; MEGF6; BSG; RCC1; DUSP14; AKT1S1

Interacting Protein

Il1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1a.
CASP1; IL1R2; CASP1; SHARPIN; HAX1

Il1a Related Articles

Caniattil, MCDL; Marchioro, AA; et al. Association of Cytokines in Individuals Sensitive and Insensitive to Dust Mites in a Brazilian Population. PLOS ONE 9:-(2014).
Ramdasi, AY; Arya, RP; et al. Effect of Pregnancy on Anti-HEV Antibody Titres, Plasma Cytokines and the Corresponding Gene Expression Levels in the PBMCs of Patients Presenting with Self-Recovering Clinical and Subclinical Hepatitis E. PLOS ONE 9:-(2014).

Il1a Related Gene Family

IL