EGF

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EGF

Official Full Name epidermal growth factor
Background This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
Synonyms Beta urogastrone; EGF; EGF-HUMAN; Epidermal Growth Factor; HOMG4; OTTHUMP00000219721; OTTHUMP00000219722; Pro epidermal growth factor; URG; Urogastrone
    • Species :
    • Canine
    • Chicken
    • Dog
    • Feline
    • Human
    • Mouse
    • Pig
    • Rat
    • Swine
    • Zebrafish
    • Source :
    • Adult Male Rat Submandibular Glands
    • Barley Grain
    • CHO
    • E.coli
    • HEK293
    • Hordeum Vulgare
    • Human Cell
    • Male Urine
    • Mammalian Cell
    • Mouse Submaxillary Gland
    • Nicotiana Benthamiana
    • NS0
    • Rabbit
    • Rice Grain
    • S.cerevisiae
    • Wheat Germ
    • Yeast
    • Tag :
    • Fc
    • His
    • GST
    • S
    • human
    • IgG1
    • Met
    • Mouse
    • IgG
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Egf-05M Recombinant Mouse Egf protein E.coli N/A
    Human EGF-333H Recombinant Human EGF Protein (Asn 971 - Arg 1023) E.coli N/A
    Canine EGF-362C Recombinant Canine EGF Protein, His-tagged E.coli His
    Human EGF-407H Recombinant Human EGF Protein (Asn971-Arg1023) Yeast N/A
    Human EGF-6282H Recombinant Human EGF protein, Mouse IgG Fc-tagged HEK293 Mouse/IgG/Fc
    Human CAB11526RH Rabbit Anti-Human Epidermal Growth Factor Monoclonal Antibody Rabbit N/A
    Human EGF-020E Recombinant Human EGF protein E.coli N/A
    Human EGF-023H Recombinant Human EGF Protein HEK293 N/A
    Human EGF-08H Recombinant Human EGF protein Rice Grain N/A
    Human EGF-100HG GMP Recombinant Human EGF protein E.coli N/A
    Human EGF-107H Recombinant Human Epidermal Growth Factor (rDNA derived) Reference standard E.coli N/A
    Human EGF-108H Recombinant Human Epidermal Growth Factor (1-52) (rDNA derived) Reference standard S.cerevisiae N/A
    Human EGF-12320H Recombinant Human EGF, GST-tagged E.coli GST
    Human EGF-1379H Recombinant Human EGF Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EGF-1549H Recombinant human EGF, Active, His-tagged Nicotiana Benthamiana His
    Human EGF-166H Recombinant Human Epidermal Growth Factor 21-Leu E.coli N/A
    Human EGF-18H Recombinant Human EGF, His-tagged Barley Grain His
    Human EGF-201H Recombinant Human EGF, Fc tagged Human Cell Fc
    Human EGF-204H Recombinant Human EGF protein, His/S-tagged E.coli His/S
    Human EGF-214H Recombinant Human EGF, StrepII-tagged Human Cell Strep II
    Human EGF-232H Recombinant Human EGF, Fc-tagged CHO Fc
    Human EGF-23H Native Human EGF protein Male Urine N/A
    Human EGF-26462TH Native Human EGF N/A
    Human EGF-2716HCL Recombinant Human EGF cell lysate Human Cell N/A
    Human EGF-2812H Recombinant Human EGF protein, His-tagged E.coli His
    Human EGF-2813H Recombinant Human EGF protein, His-tagged E.coli His
    Human EGF-3113H Recombinant Human EGF Protein, GST-tagged Wheat Germ GST
    Human EGF-470H Recombinant Human EGF, His-tagged NS0 His
    Human EGF-479H Recombinant Human EGF, Met E.coli Met
    Human EGF-545H Recombinant Mouse Epidermal Growth Factor, MIgG2a Fc-tagged CHO Fc
    Human EGF-546H Recombinant Mouse Epidermal Growth Factor, HIgG1 Fc-tagged, mutant CHO Fc
    Human EGF-547H Recombinant Mouse Epidermal Growth Factor, HIgG1 Fc-tagged CHO Fc
    Human EGF-550H Recombinant Human EGF, MIgG2a Fc-tagged CHO Fc
    Human EGF-551H Recombinant Human EGF, HIgG1 Fc-tagged CHO Fc
    Human EGF-556H Recombinant Human Epidermal Growth Factor E.coli N/A
    Human EGF-632H Recombinant Human EGF protein Yeast N/A
    Human EGF-6H Recombinant Human Epidermal Growth Factor yeast N/A
    Human EGF-9H Recombinant human EGF Hordeum Vulgare N/A
    Mouse Egf -634M Native Mouse Egf protein Mouse Submaxillary Gland N/A
    Mouse Egf-038E Recombinant Mouse Egf (977-1029aa), Met tagged E.coli N/A
    Mouse Egf-05H Recombinant Murine Epidermal Growth Factor E.coli N/A
    Mouse EGF-261M Recombinant Mouse Egf, None tagged Yeast Fc/His
    Mouse Egf-2814M Recombinant Mouse Egf protein, His & GST-tagged E.coli His/GST
    Mouse EGF-306M Recombinant Mouse Egf, Gly & Pro tagged Human Cell Fc/His
    Mouse EGF-316M Recombinant Mouse EGF, MIgG2a Fc-tagged CHO Fc
    Mouse Egf-557M Recombinant Mouse Epidermal Growth Factor E.coli N/A
    Mouse EGF-561M Recombinant Mouse Epidermal Growth Factor, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse Egf-631M Recombinant Mouse Egf E.coli Met
    Mouse Egf-634M Native Mouse Egf Mouse Submaxillary Gland N/A
    Mouse EGF-866M Recombinant Mouse Epidermal Growth Factor, His-tagged E.coli His
    Mouse Egf-868M Recombinant Mouse Egf protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Egf-873M Recombinant Mouse Egf Protein, His-tagged HEK293 His
    Mouse EGF-973MCL Recombinant Mouse EGF cell lysate Human Cell N/A
    Rat Egf -635R Native Rat Egf protein Adult Male Rat Submandibular Glands N/A
    Rat Egf -636R Recombinant Rat Egf protein E.coli N/A
    Rat EGF-2026R Recombinant Rat EGF Protein Mammalian Cell His
    Rat Egf-2816R Recombinant Rat Egf protein, His & GST-tagged E.coli His/GST
    Rat Egf-460R Recombinant Rat Epidermal Growth Factor E.coli N/A
    Rat Egf-550R Recombinant Rat Egf E.coli N/A
    Rat Egf-635R Native Rat Egf Adult Male Rat Submandibular Glands N/A
    Rat Egf-636R Recombinant Rat Egf protein E.coli N/A
    Dog EGF-2809D Recombinant Dog EGF protein, His-tagged E.coli His
    Dog EGF-2810D Recombinant Dog EGF protein, His-tagged E.coli His
    Dog EGF-2811D Recombinant Dog EGF protein, His-tagged E.coli His
    Canine EGF-4366C Recombinant Canine EGF Protein Yeast N/A
    Chicken EGF-1079C Recombinant Chicken EGF Mammalian Cell His
    Chicken EGF-4412C Recombinant Chicken EGF Protein Yeast N/A
    Zebrafish EGF-11750Z Recombinant Zebrafish EGF Mammalian Cell His
    Pig EGF-2815P Recombinant Pig EGF protein, His-tagged E.coli His
    Swine EGF-4362S Recombinant Swine EGF Protein Yeast N/A
    Feline EGF-4411F Recombinant Feline EGF Protein Yeast N/A

    EGF involved in several pathways and played different roles in them. We selected most pathways EGF participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation IL17RD; PSMD10; EGFR; PSMD5; SPTB; NRG4; FGF18B; FRS2; PEA15A; PTPRA
    Adaptive Immune System ASB7; UBE2V1; SPTBN2; ASB14; ITGB1B.1; LRR1; CD160; CD300A; KIF3B; KIF18A
    Arf6 signaling events USP6; EGF; KIF13B; EFNA1; GULP1; ADRB2; FBXO8; IPCEF1; EGFR; ADAP1
    Axon guidance COL6A2; GSK3B; SEMA4D; FRS2B; SDCBP; SPNA1; PLXND1; FRS2; SEMA4B; SRGAP1
    Bladder cancer ARAF; MYC; MAP2K2; ERBB2; TYMP; IL-8; HRAS; DAPK2; KRAS; MAPK1
    Ceramide signaling pathway EGF; CRADD; PAWR; CTSD; DERL3
    Choline metabolism in cancer PRKCG; PPAP2A; PIP5K1C; RAF1; PLA2G4D; PIK3R1; RAC1; PIP5K1A; PIK3CG; PDPK1
    Constitutive Signaling by Aberrant PI3K in Cancer FRS2; KLB; NRG4; TRAT1; HBEGF; NRG3; EGF

    EGF has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by EGF itself. We selected most functions EGF had, and list some proteins which have the same functions with EGF. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding CD248A; CASQ1A; PCDH1A6; ENPP1; MMP28; CALML4A; PROZ; SYT2; Npnt; THBD
    epidermal growth factor receptor binding FAM83B; LINGO1; GRB2; SHC1; TGFA; FER; ERBB4; PLSCR1; VAV2; TNK2
    growth factor activity FGF6B; MSTNB; PDGFC; COL20A1; AREG; PDGFA; PDGFAB; CSF1B; CTGF; RABEP1
    protein binding DIP2A; NAPRT1; AMY1A; LYN; BLOC1S3; PTH2R; TROAP; GATSL3; TRP63; FOXM1
    transmembrane receptor protein tyrosine kinase activator activity ANGPT4; GREM1; EFNA5; NRG3; EGF; NRG1

    EGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGF here. Most of them are supplied by our site. Hope this information will be useful for your research of EGF.

    EGFR; S100A4; Egfr

    Ganji, R; Nabiuni, M; et al. Development of Mouse Preantral Follicle after In Vitro Culture in A Medium Containing Melatonin. CELL JOURNAL 16:546-553(2015).
    Chen, XH; Liu, ZC; et al. TGF-beta and EGF induced HLA-I downregulation is associated with epithelial-mesenchymal transition (EMT) through upregulation of snail in prostate cancer cells. MOLECULAR IMMUNOLOGY 65:34-42(2015).

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