igf1
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  • Official Full Name
  • Insulin-like growth factor 1
  • Background
  • Insulin-like growth factor 1 (IGF-1) also known as somatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.
  • Synonyms
  • ProIGF-I; Insulin-like Growth Factor-I Precursor; IGF-IEB; IGF1; IGFI; Insulin-like Growth Factor-I; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; insulin-like growth factor I; Mechano growth factor; insulin-like growth factor IA; IGF-I; insulin-like growth factor IB; MGF; somatomedin-C; IGF-IA; IBP1; IGF-IB; Somatomedin-C; IGFI; Teprotumumab; 89957-37-9; Ganitumab; 905703-97-1
Cat.#:IGF1-384HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF1 Protein, Fc-tagged
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Cat.#:IGF1-437MTag:N/A
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IGF1 Protein
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Cat.#:IGF1-3928HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IGF1 protein
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Cat.#:IGF-08HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Long Arg3 Insulin-like Growth Factor-I
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Cat.#:IGF1-036HTag:N/A
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human IGF1 Protein
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Cat.#:IGF1-06HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IGF1 protein
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Cat.#:IGF1-09HTag:N/A
Source (Host):Rice GrainSpecies:Human
Product nameRecombinant Human IGF1 protein
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Cat.#:IGF1-124HGTag:N/A
Source (Host):E.coliSpecies:Human
Product nameGMP Recombinant Human IGF1 protein
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Cat.#:IGF1-325HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Des(1-3)Insulin-like Growth Factor 1
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Cat.#:IGF1-456HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor 1 (Somatomedin C)
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Cat.#:IGF1-471HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human IGF1 protein, His-tagged
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Cat.#:IGF1-524HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IGF1 protein
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Cat.#:IGF1-526HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF1
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Cat.#:IGF1-527HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IGF1 protein
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Cat.#:IGF1-561HTag:His|NusA
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF1, His & NusA tagged
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Cat.#:IGF1-60HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF1, None tagged
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Cat.#:IGF1-61HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IGF1
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Cat.#:IGF1-650HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Insulin Like Growth Factor-I, HIgG1 Fc-tagged, mutant
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Cat.#:IGF1-651HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Insulin Like Growth Factor-I, MIgG2a Fc-tagged
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Cat.#:IGF1-652HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Insulin Like Growth Factor-I,HIgG1 Fc-tagged
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Cat.#:IGF1-810HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF1 protein, His & GST-tagged
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Cat.#:Igf1-570MTag:N/A
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse Igf1 protein
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Cat.#:IGF1-8063MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IGF1 Protein
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Cat.#:Igf1-811MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Igf1 protein, His-tagged
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Cat.#:Igf1-812MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Igf1 protein, His & T7-tagged
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Cat.#:Igf1-173RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Igf1
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Cat.#:Igf1-590RTag:N/A
Source (Host):E.coliSpecies:Rat
Product nameRecombinant Rat Igf1 protein
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Cat.#:Igf1-814RTag:His|GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Igf1 protein, His & GST-tagged
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Cat.#:IGF1-2215RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IGF1 Protein, His-tagged
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Cat.#:IGF1-1203CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IGF1
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Cat.#:IGF1-322CTag:N/A
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken Insulin-Like Growth Factor 1 (Somatomedin C)
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Cat.#:IGF1-809CTag:His|GST
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken IGF1 protein, His & GST-tagged
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Cat.#:IGF1-815RTag:His|GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IGF1 protein, His & GST-tagged
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Cat.#:IGF1-9334ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IGF1
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Cat.#:IGF1-808CTag:His|GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IGF1 protein, His & GST-tagged
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Cat.#:IGF1-813PTag:GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IGF1 protein, GST-tagged
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Cat.#:IGF1-84GTag:N/A
Source (Host):E. coliSpecies:Gilthead Seabream
Product nameRecombinant Gilthead Seabream Insulin-Like Growth Factor 1
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Cat.#:IGF1-026ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF1 (26-95aa)
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Cat.#:IGF1-606HTag:N/A
Source (Host):Hordeum vulgareSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor 1 (somatomedin C)
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Cat.#:IGF1-657HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor 1, GST-tag
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Cat.#:IGF1-658HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor 1
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Cat.#:IGF1-687HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor 1 (somatomedin C)
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Cat.#:IGF1-691HTag:HQ
Source (Host):Hordeum vulgare (barley grain)Species:Human
Product nameRecombinant Human Insulin-Like Growth Factor 1 (somatomedin C), HQ-tagged
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Cat.#:Igf1-604RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Insulin-Like Growth Factor 1
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Cat.#:IGF1-5268HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human IGF1 293 Cell Lysate
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Cat.#:IGF1-109HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Insulin-like growth Factor 1 Reference standard
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Cat.#:IGF1-175HTag:N/A
Source (Host):Species:Human
Product nameInsulin-like growth Factor I Reference standard
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Cat.#:IGF1-P059HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF1 therapeutic protein
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Involved Pathway

IGF1 involved in several pathways and played different roles in them. We selected most pathways IGF1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
GNGT1; NF1; FGF2; PAK3; PLA2G12B; RALGDS; PAK1; RASAL3; SHC3; FGFR2
Rap signaling pathway
ITGAM; F2R; FGF4; MLLT4; INS; VEGFC; GNAI1; ANGPT4; MAPK11; RAPGEF1
HIF- signaling pathway
CUL2; NOX1; PDHB; PIK3R3; CAMK2D; LDHA; MAPK3; FLT1; IL6R; PDHA2
FoxO signaling pathway
SOS1; CCND2; MAPK8A; G6PCA.2; HOMER3; PTENA; GADD45BA; PIK3CD; GRB2; IKBKB
Oocyte meiosis
RPS6KA1; CAMK2A; PPP2R5D; CPEB1B; CALM2B; YWHABA; PRKACBA; SLKA; PPP2R5EB; FBXO43
p signaling pathway
GADD45AA; THBS1; PMAIP1; BID; CCNE2; PIDD1; SHISA5; CASP9; SERPINB5; TSC2
mTOR signaling pathway
AKT1; TSC1A; PRKAA2; EIF4EA; PIK3R2; EIF4E2RS1; AKT3A; ULK2; IKBKB; PIK3R3
PIK-Akt signaling pathway
IGF1; TCL1B; PDGFD; THBS4; YWHAG; PRKAA2; IFNA5; FGF19; PPP2R5A; MTOR
AMPK signaling pathway
STK11; PFKL; PFKM; PIK3R1; IRS1; PRKAA1; CCNA2; Scd1; CD36; ADIPOQ
Focal adhesion
RAP1A; BIRC3; MYLPFA; VAV3; PTK2AB; ARHGAP5; HRASB; FYNA; IGF1RA; MET
Signaling pathways regulating pluripotency of stem cells
LHX5; BMP4; MAPK13; WNT1; NODAL; PAX6; BMPR1B; BMPR2; ACVR2B; WNT8B
Long-term depression
PPP2R1A; GRIA3; GNAQ; PLCB2; IGF1; RAF1; ITPR1; CRHR1; BRAF; GRID2
Inflammatory mediator regulation of TRP channels
IL1B; CAMK2G; CYP2C55; CALM2; PLA2G4A; PIK3R3; MAPK8; ACCN5; PLA2G4F; PIK3CD
Ovarian steroidogenesis
LHB; HSD3B6; CYP2J5; GNAS; PLA2G4F; HSD17B2; PRKACB; INS2; IGF1; HSD3B5
Progesterone-mediated oocyte maturation
IGF1RA; RAF1B; ADCY1A; CDC27; INS2; CPEB2; PIK3R5; PIK3CA; AKT2L; RPS6KA2
Aldosterone-regulated sodium reabsorption
PIK3CD; INS1; ALPHA-ENAC; SLC9A3R2; ATP1A3; PRKCG; PIK3CG; PIK3CB; ATP1A1; KCNJ1
Pathways in cancer
GLI2; TGFA; STAT3; GSTP1; FADD; EGLN2; IGF1R; AXIN1; FZD5; VEGFA
Transcriptional misregulation in cancer
HPGD; MYCN; GZMB; Pdgfa&Pdgfb; FCGR1; FOXO1; Itgam&Itgb2; PLAU; EYA1; PER2
Proteoglycans in cancer
CTTN; FZD6; CBLC; TWIST1; WNT2B; PPP1R12B; PRKACG; SRC; PIK3R3; ROCK2
Glioma
PTEN; SHC3; AKT2; CALML5; SOS1; CALM1; CALM3; CAMK2A; Pdgfa&Pdgfb; RAF1
Prostate cancer
ATF4; EP300; TGFA; PIK3R5; MTOR; HSP90B1; CREB3L2; SOS1; PTEN; MAPK1
Melanoma
MITF; FGF4; Fgf15; AKT1; FGF6; CCND1; BAD; BRAF; PDGFA; PIK3CG
Hypertrophic cardiomyopathy (HCM)
ITGA9; ITGA2; ITGB5; ITGAV; RYR2; CACNG7; SLC8A1; TNNI3; ITGA7; PRKAB2
Dilated cardiomyopathy
ADRB1; ITGB4; ACTB; ACTG1; ITGB6; Adcy4; GNAS; ATP2A2; CACNB1; DES

Protein Function

IGF1 has several biochemical functions, for example, growth factor activity, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1 itself. We selected most functions IGF1 had, and list some proteins which have the same functions with IGF1. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor activity
Related Protein BMP2B; Kitl; HBEGFA; INHBB; BMP8A; MDKA; INHBAB; FGF11A; GDF9; FGF13
Function hormone activity
Related Protein FNDC5B; PTHLHA; APLN; Retnla; INS; FNDC5; THPO; CHGB; EDN1; INSL3
Function insulin receptor binding
Related Protein FRS2A; SNX2; FRS3; DOK3; PTPN11; DOK7; INS2; SNX1; INS; DOK1B
Function insulin-like growth factor receptor binding
Related Protein YWHAH; IGF2A; IGF2B; IGF1; PIK3R1; SHC1; SOCS2; IGF2; SOCS1; Ren1
Function integrin binding
Related Protein CALR; NF2; DST; JAM3; VTN; ECM2; LYN; TGFBI; FN1; CXADR
Function protein binding
Related Protein CLK2; MYOG; NAA10; RNF138; GOLGA7; MRPS31; MET; TMEM100; SPATA7; WASF2

Interacting Protein

IGF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1.
IGF1R; Igfbp5; INSR

IGF1 Related Articles

Luque, RM; Ibanez-Costa, A; et al. Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. CANCER LETTERS 359:299-306(2015).
Schofl, C; Grussendorf, M; et al. Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. EUROPEAN JOURNAL OF ENDOCRINOLOGY 172:351-356(2015).