IGF1 Protein, Insulin-like growth factor 1

IGF1

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IGF1

Official Full Name Insulin-like growth factor 1
Background Insulin-like growth factor 1 (IGF-1) also known as somatomedin C is a protein that in humans is encoded by the IGF1 gene. IGF-1 has also been referred to as a "sulfation factor" and its effects were termed "nonsuppressible insulin-like activity" (NSILA) in the 1970s. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons.
Synonyms ProIGF-I; Insulin-like Growth Factor-I Precursor; IGF-IEB; IGF1; IGFI; Insulin-like Growth Factor-I; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; insulin-like growth factor I; Mechano growth factor; insulin-like growth factor IA; IGF-I; insulin-like growth factor IB; MGF; somatomedin-C; IGF-IA; IBP1; IGF-IB; Somatomedin-C; IGFI; Teprotumumab; 89957-37-9; Ganitumab; 905703-97-1
    • Species :
    • Cattle
    • Chicken
    • Gilthead Seabream
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human
    • Mammalian Cell
    • Rice Grain
    • Yeast
    • Tag :
    • C-Myc/DDK
    • Fc
    • GST
    • His
    • NusA
    • T7
    • HQ
    • human
    • IgG1
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IGF1-020H Recombinant Human IGF1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Igf1-079M Recombinant Mouse Igf1 Protein E.coli
    Mouse Igf1-080M Recombinant Mouse Igf1 Protein E.coli
    Mouse Igf1-081M Recombinant Mouse Igf1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human IGF1-384H Recombinant Human IGF1 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IGF1-3928H Recombinant Human IGF1 protein E.coli N/A
    Mouse IGF1-437M Recombinant Mouse IGF1 Protein Yeast N/A
    Human IGF1-867HG GMP Recombinant Human IGF1 protein, Fc-tagged HEK293 Fc
    Human IGF1-868HG GMP Recombinant Human IGF1 protein, His-tagged HEK293 His
    Human IGF-08H Recombinant Human Long Arg3 Insulin-like Growth Factor-I E.coli N/A
    Human IGF1-026E Recombinant Human IGF1 (26-95aa) E.coli N/A
    Human IGF1-036H Recombinant Human IGF1 Protein HEK293 N/A
    Human IGF1-06H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-09H Recombinant Human IGF1 protein Rice Grain N/A
    Human IGF1-109H Recombinant Human Insulin-like growth Factor 1 Reference standard Yeast N/A
    Human IGF1-124HG GMP Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-175H Insulin-like growth Factor I Reference standard N/A
    Human IGF1-325H Recombinant Human Des(1-3)Insulin-like Growth Factor 1 N/A
    Human IGF1-456H Recombinant Human Insulin-like Growth Factor 1 (Somatomedin C) Yeast N/A
    Human IGF1-471H Recombinant Human IGF1 protein, His-tagged HEK293F His
    Human IGF1-524H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-5268HCL Recombinant Human IGF1 293 Cell Lysate HEK293 N/A
    Human IGF1-526H Recombinant Human IGF1 E.coli N/A
    Human IGF1-527H Recombinant Human IGF1 protein E.coli N/A
    Human IGF1-561H Recombinant Human IGF1, His & NusA tagged E.coli His/NusA
    Human IGF1-606H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) Hordeum Vulgare N/A
    Human IGF1-60H Recombinant Human IGF1, None tagged E.coli N/A
    Human IGF1-61H Recombinant Human IGF1 Yeast N/A
    Human IGF1-650H Recombinant Human Insulin Like Growth Factor-I, HIgG1 Fc-tagged, mutant CHO Fc
    Human IGF1-651H Recombinant Human Insulin Like Growth Factor-I, MIgG2a Fc-tagged CHO Fc
    Human IGF1-652H Recombinant Human Insulin Like Growth Factor-I,HIgG1 Fc-tagged CHO Fc
    Human IGF1-657H Recombinant Human Insulin-Like Growth Factor 1, GST-tag Human GST
    Human IGF1-658H Recombinant Human Insulin-like Growth Factor 1 Human N/A
    Human IGF1-687H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C) E.coli N/A
    Human IGF1-691H Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C), HQ-tagged Hordeum Vulgare HQ
    Human IGF1-810H Recombinant Human IGF1 protein, His & GST-tagged E.coli His/GST
    Human IGF1-P059H Recombinant Human IGF1 therapeutic protein E.coli N/A
    Mouse Igf1-570M Recombinant Mouse Igf1 protein E.coli N/A
    Mouse IGF1-8063M Recombinant Mouse IGF1 Protein Mammalian Cell His
    Mouse Igf1-811M Recombinant Mouse Igf1 protein, His-tagged E.coli His
    Mouse Igf1-812M Recombinant Mouse Igf1 protein, His & T7-tagged E.coli His/T7
    Rat Igf1-173R Recombinant Rat Igf1 E.coli N/A
    Rat Igf1-590R Recombinant Rat Igf1 protein E.coli N/A
    Rat Igf1-604R Recombinant Rat Insulin-Like Growth Factor 1 E.coli N/A
    Rat Igf1-814R Recombinant Rat Igf1 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque IGF1-2215R Recombinant Rhesus monkey IGF1 Protein, His-tagged Mammalian Cell His
    Chicken IGF1-1203C Recombinant Chicken IGF1 Mammalian Cell His
    Chicken IGF1-322C Recombinant Chicken Insulin-Like Growth Factor 1 (Somatomedin C) E.coli N/A
    Chicken IGF1-809C Recombinant Chicken IGF1 protein, His & GST-tagged E.coli His/GST
    Rabbit IGF1-815R Recombinant Rabbit IGF1 protein, His & GST-tagged E.coli His/GST
    Zebrafish IGF1-9334Z Recombinant Zebrafish IGF1 Mammalian Cell His
    Cattle IGF1-808C Recombinant Cattle IGF1 protein, His & GST-tagged E.coli His/GST
    Pig IGF1-813P Recombinant Pig IGF1 protein, GST-tagged E.coli GST
    Gilthead Seabream IGF1-84G Recombinant Gilthead Seabream Insulin-Like Growth Factor 1 E.coli N/A

    IGF1 involved in several pathways and played different roles in them. We selected most pathways IGF1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway PLA2G4D; PLA2G5; NGF; PLA2G2F; PRKCG; BRAP; MAP2K2; FGF3; RRAS2; GNG12
    Rap signaling pathway FGFR3; RALB; MAP2K2; FGF1; ANGPT1; PIK3CB; FGF10; PRKCZ; PLCB1; PRKD2
    HIF- signaling pathway LDHA; NOX1; PIK3CD; PIK3CB; MKNK1; ANGPT2; ALDOA; MKNK2; RBX1; NOS2
    FoxO signaling pathway AKT3A; PCK1; KRAS; TGFB1; PLK2; INS1; GABARAPL2; MAPK14B; IRS2; GRB2
    Oocyte meiosis FBXW11A; CALM2A; FBXW11B; RPS6KA1; CALM3; CUL1A; SMC1AL; YWHAB; CDK1; CAMK2D1
    p signaling pathway CCND3; BID; PPM1DA; PTENB; TP53; THBS1; RPRMA; TP53I3; CASP8; FAS
    mTOR signaling pathway PRKCA; AKT2L; PIK3CB; RPS6KB1B; MTOR; DDIT4; PRKCBB; EIF4E1B; AKT1; RRAGCB
    PIK-Akt signaling pathway COL6A6; IL6; FIGF; PIK3R3; FGF10; PPP2R1A; GNG12; Ifna11; CREB3L3; FGF2
    AMPK signaling pathway PIK3R2; ADRa1A; PIK3CG; PPP2R3A; PRKAA2; CREB3L1; MTOR; HMGCR; PRKAG1; PPP2R5B
    Focal adhesion GRB2A; TNK2; AASS; MET; ERBB2; TNN; VASP; ELK1; SHC2; VWF
    Signaling pathways regulating pluripotency of stem cells POU5F1; INHBA; AKT1; MAPK1; SMAD4; SMAD2; ID3; RAF1; WNT11; Fzd4
    Long-term depression ARAF; GNAS; MAP2K2; GNAO1; BRAF; GRIA1; GRIA3; PLCB4; PPP2CA; NOS1
    Inflammatory mediator regulation of TRP channels MAPK8; PLCB4; PLCB3; ACCN4; ASIC1; PTGER4; MAPK12; CAMK2D; GNAQ; CYP4A14
    Ovarian steroidogenesis IGF1; HSD3B5; ACOT2; HSD3B2; CYP2J6; GDF9; Adcy4; PLA2G4A; PTGS2; FSHR
    Progesterone-mediated oocyte maturation CDC26; RAF1B; Adcy4; KRAS; ANAPC2; RPS6KA6; PRKACB; BUB1; MAPK12A; PRKACAB
    Aldosterone-regulated sodium reabsorption PIK3CB; INS; SFN; MAPK1; INS2; PRKCB; KRAS; PIK3R5; ATP1B1; INSR
    Pathways in cancer KRAS; TPR; PRKACB; RAC1; PLCB4; WNT8B; PGF; PIAS2; FZD2; BAD
    Transcriptional misregulation in cancer TAF15; PML; PAX5; IL3; CD40; Pdgfa&Pdgfb; FOXO1; TRP53; HIST1H3A; ITGB7
    Proteoglycans in cancer CD63; PIK3R1; VTN; WNT9A; MAPK11; WNT2B; FASLG; NANOG; BRAF; PLAUR
    Glioma PDGFRA; PRKCB; PIK3CB; AKT2; CALML5; PIK3CA; PRKCA; MTOR; CALM4; CAMK2D
    Prostate cancer GSK3B; AKT2; KRAS; GSTP1; CCND1; SPRY1; ATF4; BAD; PIK3R3; SRD5A2
    Melanoma FGF2; PIK3R1; FGF16; PDGFRB; FGF22; FGF10; FGF21; CDH1; RAF1; MAPK3
    Hypertrophic cardiomyopathy (HCM) PRKAB1; TGFB3; ACTB; CACNB4; CACNG8; PRKAA2; PRKAB2; SGCB; MYL3; ITGB5
    Dilated cardiomyopathy EMD; ITGA9; LMNA; ITGB7; Itga10&Itgb1; ITGB6; CACNG4; CACNB2; DAG1; PRKACB

    IGF1 has several biochemical functions, for example, growth factor activity, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1 itself. We selected most functions IGF1 had, and list some proteins which have the same functions with IGF1. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity Kitl; BMP10; PDGFB; FGF14; FGF20; CXCL1; FGF10B; BMP5; GDNF; BMP7A
    hormone activity INHBE; PRL6A1; INHA; BNP; STC2A; SST2; UTS2D; PTH1B; ADM2A; TTR
    insulin receptor binding SNX1; PTPN1; DOK4; LMBRD1; DOK2; SNX2; PHIP; DOK1; SLC2A2; DOK7
    insulin-like growth factor receptor binding INSL4; Ren1; PIK3R1; IGF2; REN; IGF2B; IGF2A; INSR; YWHAG; SHC1
    integrin binding COL5A1; LAMB1; NIPAL1; FBLN1; COL3A1; PXN; ITGB1BP2; TIMP2; VWF; ECM2
    protein binding ASCL4; APOBEC3F; SLA2; MRPS16; VPS45; HSPE1; UFL1; EIF2S3; FAM69A; FAM123A

    IGF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1.

    IGF1R; Igfbp5; INSR

    Luque, RM; Ibanez-Costa, A; et al. Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas. CANCER LETTERS 359:299-306(2015).
    Schofl, C; Grussendorf, M; et al. Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. EUROPEAN JOURNAL OF ENDOCRINOLOGY 172:351-356(2015).

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