il18
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  • Official Full Name
  • interleukin 18
  • Background
  • The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011] Interleukin 18 (IL-18) is an 18-kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24-kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-γ is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-γ activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-γ also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-γ. Pleiotropic effects of IL-18 have also been reported, such as, enhancement production of IFN-γ and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-γ in T cells, enhancement of Fas ligand expression by Th1 cells.
  • Synonyms
  • IL18; interleukin 18; IGIF; IL-18; IL-1g; IL1F4; interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); interferon-gamma-inducing factor
Cat.#:IL18-1237HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL18
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Cat.#:IL18-186HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18 Protein
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Cat.#:IL18-1941HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18, His-tagged
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Cat.#:IL18-336HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18 protein
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Cat.#:IL18-490HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL18, His tagged
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Cat.#:IL18-500HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human IL18
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Cat.#:IL18-546HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL18, MIgG2a Fc-tagged
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Cat.#:IL18-547HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL18, HIgG1 Fc-tagged, mutant
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Cat.#:IL18-551HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL18, HIgG1 Fc-tagged
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Cat.#:IL18-574HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18, GST tagged
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Cat.#:IL18-638MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL18, MIgG2a Fc-tagged, mutant
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Cat.#:IL18-639MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL18, MIgG2a Fc-tagged
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Cat.#:IL18-83MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IL-18
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Cat.#:Il18-8667MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il18, None tagged
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Cat.#:IL18-3031RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL18 Protein
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Cat.#:Il18-436RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il18
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Cat.#:Il18-877RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il18 protein, His-tagged
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Cat.#:IL18-385CTag:His
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL18, His tagged
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Cat.#:IL18-2236RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL18 Protein, His-tagged
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Cat.#:IL18-370RTag:
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Macaque IL18
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Cat.#:IL18-01DTag:
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog Interleukin-18
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Cat.#:IL18-874DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL18 protein, His-tagged
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Cat.#:IL18-6176CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL18
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Cat.#:IL18-875CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken IL18 protein, His-tagged
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Cat.#:IL18-878RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL18 protein, His & T7-tagged
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Cat.#:IL18-208ETag:N/A
Source (Host):E. coliSpecies:Equine
Product nameRecombinant Equine IL18
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Cat.#:IL18-873CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL18 protein, His & T7-tagged
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Cat.#:IL18-876PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL18 protein, His & T7-tagged
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Cat.#:IL18-946PTag:His
Source (Host):E. coliSpecies:Porcine
Product nameRecombinant Porcine IL18 Protein, His-tagged
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Cat.#:IL18-335HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18 (37-193aa)
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Cat.#:IL18-433HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 18
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Cat.#:IL18-536HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 18, His-tagged
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Cat.#:IL18-742HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 18 (interferon-gamma-inducing factor)
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Cat.#:Il18-740MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 18, His-tagged
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Cat.#:Il18-522RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 18
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Cat.#:II18-272MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 18
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Cat.#:IL18-344HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL18 lysate
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Cat.#:IL18-153HGTag:His
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human IL18 Protein
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Cat.#:IL18-17HTag:
Source (Host):Species:Human
Product nameHuman IL18 Reference standard
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IL18 Related Articles

Chen, GL; Fu, PF; et al. Immune Responses of Piglets Immunized by a Recombinant Plasmid Containing Porcine Circovirus Type 2 and Porcine Interleukin-18 Genes. VIRAL IMMUNOLOGY 27:521-528(2014).
Ovsyannikova, IG; Pankratz, VS; et al. HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study. HUMAN GENETICS 133:1083-1092(2014).

IL18 Related Gene Family

IL