il18
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  • Official Full Name
  • interleukin 18
  • Background
  • The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011] Interleukin 18 (IL-18) is an 18-kDa cytokine which identified as a costimulatory factor for production of interferon-γ (IFN-γ) in response to toxic shock and shares functional similarities with IL-12. IL-18 is synthesized as a precursor 24-kDa molecule without a signal peptide and must be cleaved to produce an active molecule. IL-1 converting enzyme (ICE, Caspase-1) cleaves pro-IL-18 at aspartic acid in the P1 position, producing the mature, bioactive peptide that is readily released from the cells. It is reported that IL-18 is produced from Kupffer cells, activated macrophages, keratinocytes, intestinal epithelial cells, osteoblasts, adrenal cortex cells and murine diencephalon. IFN-γ is produced by activated T or NK cells and plays critical roles in the defense against microbiral pathogens. IFN-γ activates macrophages and enhances NK activity and B cell maturation, proliferation and Ig secretion. IFN-γ also induces expression of MHC class I and II antigens and inhibits osteoclast activation. IL-18 acts on T helper type-1 (Th1) T cells and in combination with IL-12 strongly induces them to produce IFN-γ. Pleiotropic effects of IL-18 have also been reported, such as, enhancement production of IFN-γ and GM-CSF in peripheral blood mononuclear cells, production of Th1 cytokines, IL-2, GM-CSF and IFN-γ in T cells, enhancement of Fas ligand expression by Th1 cells.
  • Synonyms
  • IL18; interleukin 18; IGIF; IL-18; IL-1g; IL1F4; interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor); interferon-gamma-inducing factor
Cat.#:IL18-1237HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL18
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Cat.#:IL18-186HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18 Protein
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Cat.#:IL18-1941HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18, His-tagged
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Cat.#:IL18-336HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18 protein
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Cat.#:IL18-490HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL18, His tagged
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Cat.#:IL18-500HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human IL18
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Cat.#:IL18-546HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL18, MIgG2a Fc-tagged
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Cat.#:IL18-547HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL18, HIgG1 Fc-tagged, mutant
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Cat.#:IL18-551HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL18, HIgG1 Fc-tagged
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Cat.#:IL18-574HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18, GST tagged
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Cat.#:IL18-638MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL18, MIgG2a Fc-tagged, mutant
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Cat.#:IL18-639MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL18, MIgG2a Fc-tagged
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Cat.#:IL18-83MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IL-18
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Cat.#:Il18-8667MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il18, None tagged
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Cat.#:IL18-3031RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL18 Protein
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Cat.#:Il18-436RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il18
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Cat.#:Il18-877RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il18 protein, His-tagged
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Cat.#:IL18-385CTag:His
Source (Host):E. coliSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL18, His tagged
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Cat.#:IL18-2236RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL18 Protein, His-tagged
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Cat.#:IL18-370RTag:
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus Macaque IL18
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Cat.#:IL18-01DTag:
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog Interleukin-18
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Cat.#:IL18-874DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL18 protein, His-tagged
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Cat.#:IL18-6176CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL18
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Cat.#:IL18-875CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken IL18 protein, His-tagged
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Cat.#:IL18-878RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL18 protein, His & T7-tagged
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Cat.#:IL18-208ETag:N/A
Source (Host):E. coliSpecies:Equine
Product nameRecombinant Equine IL18
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Cat.#:IL18-873CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL18 protein, His & T7-tagged
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Cat.#:IL18-876PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL18 protein, His & T7-tagged
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Cat.#:IL18-946PTag:His
Source (Host):E. coliSpecies:Porcine
Product nameRecombinant Porcine IL18 Protein, His-tagged
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Cat.#:IL18-335HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL18 (37-193aa)
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Cat.#:IL18-433HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 18
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Cat.#:IL18-536HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 18, His-tagged
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Cat.#:IL18-742HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 18 (interferon-gamma-inducing factor)
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Cat.#:Il18-740MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 18, His-tagged
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Cat.#:Il18-522RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 18
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Cat.#:II18-272MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 18
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Cat.#:IL18-344HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL18 lysate
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Cat.#:IL18-153HGTag:His
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human IL18 Protein
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Cat.#:IL18-17HTag:
Source (Host):Species:Human
Product nameHuman IL18 Reference standard
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Involved Pathway

IL18 involved in several pathways and played different roles in them. We selected most pathways IL18 participated on our site, such as Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CCL13; TNFRSF18; CD40; IL1R1; IL17A; PF4V1; IL15RA; IFNA5; CXCR2; CCL17
NOD-like receptor signaling pathway
BIRC3; CARD9; MAPK11; HSP90AA1.1; CASP1; PYDC1; MAPK8; CXCL8B.3; Ccl12; IL1B
Cytosolic DNA-sensing pathway
IL6; IFI202B; AIM2; RIPK3; IKBKB; CASPA; NFKBIA; POLR2F; IFNB; NFKB1
Salmonella infection
RAC1A; RHOGB; ARPC5LB; ARPC4L; MAPK11; MAPK10; PFN4; MAPK13; CCL3; WASL
Legionellosis
HSPA1A; APAF1; NLRC4; Casp3; EEF1A1; IL12B; HSPA8; CR1; TLR2; IL1B
African trypanosomiasis
GNAQ; HBA-A2; IL6; APOL1; Fasl; IL10; IL1B2; HBB-B1; TNF; PLCB2
Malaria
THBS1; THBS2; KLRB1; CSF3; SDC1; GYPC; CD81; SELE; CCL2; THBS3
Tuberculosis
MAPK10; IFNA7; IFNA5; IFNA8; MRC1; HLA-DRB5; ATP6V0D1; RELA; IFNGR2; ITGAM
Influenza A
IL18; RAE1; IKBKE; NLRP3; HLA-DRB3; PIK3CD; EIF2AK1; HLA-DQA1; EIF2AK2; PYCARD
Inflammatory bowel disease (IBD)
HLA-DQA2; IL12A; IL23; TGFB2; SMAD2; FOXP3; IL21; Il2; RORC; IL1A
Rheumatoid arthritis
IL6; TEK; MMP3; CCL3L3; HLA-DOA; Il23a; ATP6V1E2; ATP6V1F; ATP6V1H; ATP6V1G1

Protein Function

IL18 has several biochemical functions, for example, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL18 itself. We selected most functions IL18 had, and list some proteins which have the same functions with IL18. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein Il1f9; IL7; GREM2; CMTM6; FLT3LG; RNF207B; IL36B; CCL20B; GDF5; IL17C
Function protein binding
Related Protein CCR1; HMGB2; TSPAN15; NDFIP2; AMPH; CCDC28B; PRKAA2; LDHA; THAP7; SETD6

Interacting Protein

IL18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL18 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL18.
IL18R1; CASK; Cul1

IL18 Related Articles

Chen, GL; Fu, PF; et al. Immune Responses of Piglets Immunized by a Recombinant Plasmid Containing Porcine Circovirus Type 2 and Porcine Interleukin-18 Genes. VIRAL IMMUNOLOGY 27:521-528(2014).
Ovsyannikova, IG; Pankratz, VS; et al. HLA alleles associated with the adaptive immune response to smallpox vaccine: a replication study. HUMAN GENETICS 133:1083-1092(2014).

IL18 Related Gene Family

IL