cd274
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  • Official Full Name
  • CD274 CD274 molecule
  • Background
  • PD-L1, also known as CD274, B7-H1, is a 40 kD type I transmembrane protein member of B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-gamma activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production.
  • Synonyms
  • CD274; CD274 molecule; CD274 antigen , PDCD1LG1, programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; B7 H; B7 H1; B7H1; PD L1; PDL1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1; B7-H; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296;
Cat.#:CD274-199CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Human CD274 Protein, His-tagged
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Cat.#:CD274-593HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 Protein
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Cat.#:CD274-002HATag:MIgG2a Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, MIgG2a Fc-tagged, APC labeled
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Cat.#:CD274-002HPTag:MIgG2a Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, MIgG2a Fc-tagged, R-PE labeled
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Cat.#:CD274-010HATag:mutant HIgG1 Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, mutant HIgG1 Fc-tagged, APC labeled
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Cat.#:CD274-010HPTag:mutant HIgG1 Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, mutant HIgG1 Fc-tagged, R-PE labeled
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Cat.#:CD274-020HATag:HIgG1 Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, HIgG1 Fc-tagged, APC labeled
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Cat.#:CD274-020HPTag:HIgG1 Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, HIgG1 Fc-tagged, R-PE labeled
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Cat.#:CD274-1058CATag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD274 protein, Fc-tagged, APC labeled
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Cat.#:CD274-1058CPTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD274 protein, Fc-tagged, R-PE labeled
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Cat.#:CD274-130CATag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD274 protein, Fc-tagged, APC labeled
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Cat.#:CD274-130CPTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD274 protein, Fc-tagged, R-PE labeled
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Cat.#:CD274-167CATag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD274 protein, Fc-tagged, APC labeled
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Cat.#:CD274-167CPTag:Fc
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CD274 protein, Fc-tagged, R-PE labeled
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Cat.#:Cd274-1707MATag:Fc
Source (Host):NS0 CellsSpecies:Mouse
Product nameRecombinant Mouse Cd274 protein, Fc-tagged, APC labeled
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Cat.#:Cd274-1707MPTag:Fc
Source (Host):NS0 CellsSpecies:Mouse
Product nameRecombinant Mouse Cd274 protein, Fc-tagged, R-PE labeled
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Cat.#:CD274-175HATag:Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, Fc-tagged, APC labeled
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Cat.#:CD274-175HPTag:Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, Fc-tagged, R-PE labeled
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Cat.#:CD274-178HATag:Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, Fc-tagged, APC labeled
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Cat.#:CD274-178HPTag:Fc
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD274 protein, Fc-tagged, R-PE labeled
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Cat.#:CD274-188MATag:MIgG2a Fc
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse CD274 protein, MIgG2a Fc-tagged, APC labeled
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Cat.#:CD274-188MPTag:MIgG2a Fc
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse CD274 protein, MIgG2a Fc-tagged, R-PE labeled
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Cat.#:CD274-189MATag:mutant MIgG2a Fc
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse CD274 protein, mutant MIgG2a Fc-tagged, APC labeled
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Cat.#:CD274-189MPTag:mutant MIgG2a Fc
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse CD274 protein, mutant MIgG2a Fc-tagged, R-PE labeled
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Cat.#:CD274-199CATag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey CD274 protein, Fc-tagged, APC labeled
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Cat.#:CD274-199CPTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey CD274 protein, Fc-tagged, R-PE labeled
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Cat.#:CD274-2142HATag:Fc
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CD274 protein, Fc-tagged, APC labeled
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Cat.#:CD274-2142HPTag:Fc
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CD274 protein, Fc-tagged, R-PE labeled
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Cat.#:CD274-2146HATag:mouse IgG1-Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 protein, mouse IgG1-Fc-tagged, APC labeled
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Cat.#:CD274-2146HPTag:mouse IgG1-Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 protein, mouse IgG1-Fc-tagged, R-PE labeled
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Cat.#:CD274-2330HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 protein, Fc-tagged, APC labeled
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Cat.#:CD274-2330HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 protein, Fc-tagged, R-PE labeled
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Cat.#:CD274-339HTag:HIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 Protein (Met1-Thr239), HIgG1 Fc-tagged, Biotinylated
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Cat.#:CD274-358HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 Protein (Phe 19 - Arg 238), Fc-tagged
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Cat.#:Cd274-359MATag:mouse IgG2a Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274 protein, mouse IgG2a Fc-tagged, APC labeled
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Cat.#:Cd274-359MPTag:mouse IgG2a Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274 protein, mouse IgG2a Fc-tagged, R-PE labeled
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Cat.#:CD274-364HTag:MIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 Protein, MIgG1 Fc-tagged, low endotoxin
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Cat.#:CD274-365HTag:His & Fc & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 Protein, His & Fc & Avi-tagged, Biotinylated
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Cat.#:CD274-366MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD274 Protein (Phe 19 - Thr 238), Fc-tagged
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Cat.#:CD274-379HTag:LIgG2b Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 Protein, LIgG2b Fc-tagged, low endotoxin
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Cat.#:Cd274-561RATag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd274 protein, Fc-tagged, APC labeled
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Cat.#:Cd274-561RPTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd274 protein, Fc-tagged, R-PE labeled
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Cat.#:Cd274-593MATag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274 protein, Fc-His-tagged, APC labeled
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Cat.#:Cd274-593MPTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274 protein, Fc-His-tagged, R-PE labeled
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Cat.#:CD274-785MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD274 Protein (Met1-Thr238), His-tagged, Biotinylated
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Cat.#:Cd274-821MATag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274 protein, Fc-tagged, APC labeled
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Cat.#:Cd274-821MPTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274 protein, Fc-tagged, R-PE labeled
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Cat.#:CD274-0763HTag:His-Flag-StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD274 Protein, His-Flag-StrepII-Tagged
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Cat.#:CD274-0765HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD274 Protein, GST-Tagged
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Cat.#:CD274-4380CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine CD274 Protein
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Cat.#:CD274-4367RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit CD274 Protein
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Cat.#:CD274-2142HTag:Fc
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CD274 Molecule, Fc Chimera
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Cat.#:CD274-002HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD274, MIgG2a Fc-tagged
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Cat.#:CD274-010HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD274, HIgG1 Fc-tagged, mutant
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Cat.#:CD274-020HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD274, HIgG1 Fc-tagged
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Cat.#:CD274-1283HTag:Avi & His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 protein, Avi & His-tagged, Biotinylated
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Cat.#:CD274-1284HTag:Avi & Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 protein, Avi & Fc-tagged, Biotinylated
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Cat.#:CD274-170HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 Protein, DDK/His-tagged
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Cat.#:CD274-172HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CD274 Protein, DDK-tagged
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Cat.#:CD274-173HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CD274 Protein, DDK-tagged
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Cat.#:CD274-175HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD274, Fc-tagged
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Cat.#:CD274-178HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD274 Protein, Fc-tagged
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Cat.#:CD274-194HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274, Twin-Strep-tagged
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Cat.#:CD274-2145HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 protein, His-tagged
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Cat.#:CD274-2146HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274, mouse IgG1-Fc-tagged
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Cat.#:CD274-2330HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274, Fc tagged
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Cat.#:CD274-256HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274, His-tagged, Biotinylated
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Cat.#:CD274-27112THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CD274
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Cat.#:CD274-3920HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CD274 protein, DDK-tagged
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Cat.#:CD274-592HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274, His tagged
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Cat.#:CD274-6775HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD274 Molecule, His-tagged
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Cat.#:CD274-785HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 protein, His-tagged, biotinylated
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Cat.#:CD274-8229HTag:Biotin-His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274, Biotin-His-tagged
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Cat.#:CD274-8230HTag:His/Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 protein, His/Fc-tagged, Biotinylated
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Cat.#:CD274-8315HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human CD274
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Cat.#:CD274-1285MTag:Avi & Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD274 protein, Avi & Fc-tagged, Biotinylated
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Cat.#:Cd274-1707MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse CD274 Antigen, Fc-tagged
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Cat.#:CD274-188MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse CD274, MIgG2a Fc-tagged
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Cat.#:CD274-189MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Interleukin CD274, MIgG2a Fc-tagged, mutant
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Cat.#:Cd274-2275MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274, His tagged
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Cat.#:Cd274-359MTag:mouse IgG2a Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274 protein, mouse IgG2a Fc-tagged
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Cat.#:Cd274-593MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274, Fc-His tagged
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Cat.#:Cd274-6957MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse CD274 Antigen, His-tagged
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Cat.#:Cd274-721MTag:Fc
Source (Host):Human cellsSpecies:Mouse
Product nameRecombinant Mouse Cd274, Fc-tagged, Biotinylated
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Cat.#:Cd274-7691MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd274 protein, His & T7-tagged
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Cat.#:Cd274-821MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Cd274 Protein, Fc-tagged
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Cat.#:Cd274-561RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd274, Fc-tagged
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Cat.#:Cd274-562RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Cd274, His-tagged
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Cat.#:Cd274-7693RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd274 protein, His & GST-tagged
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Cat.#:CD274-130CTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD274, Fc tagged
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Cat.#:CD274-131CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD274, His tagged
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Cat.#:CD274-167CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD274, Fc-tagged
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Cat.#:CD274-168CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD274, His-tagged
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Cat.#:CD274-732RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CD274 Protein, His-tagged
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Cat.#:CD274-1058CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine CD274 Protein, Fc-tagged
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Cat.#:CD274-2735HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD274 cell lysate
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Cat.#:CD274-2642MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD274 cell lysate
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Cat.#:CD274-002RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat CD274 cell lysate
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Cat.#:CD274-914CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CD274 cell lysate
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Involved Pathway

CD274 involved in several pathways and played different roles in them. We selected most pathways CD274 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD274 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
NRXN1A; CD86; HLA-DOB; CLDN17; MPZL1L; NADL1.2; CNTNAP2A; CLDN15; PDCD1LG2; BLB1

Protein Function

CD274 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD274 itself. We selected most functions CD274 had, and list some proteins which have the same functions with CD274. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein CGGBP1; SUPT4H1; PGBD1; TCOF1; EXOSC10; WTIP; TMEM119; TRP53; GNS; RPIA

Interacting Protein

CD274 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD274 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD274.
CD80; PDCD1

CD274 Related Articles

Markwick, LJL; Riva, A; et al. Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients With Acute Alcoholic Hepatitis. GASTROENTEROLOGY 148:590-+(2015).
Ritprajak, P; Azuma, M; et al. Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma. ORAL ONCOLOGY 51:221-228(2015).