il17a
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  • Official Full Name
  • interleukin 17A
  • Background
  • The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
  • Synonyms
  • IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8);
Cat.#:IL17A-001CTag:
Source (Host):YeastSpecies:Cynomolgus monkey
Product nameRecombinant Cynomolgus Monkey IL17A Protein
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Cat.#:IL17A-381MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL17A Protein, His-tagged
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Cat.#:IL17A-440RTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Rabbit
Product nameRecombinant Rabbit IL17 Protein, His-tagged
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Cat.#:IL17A-441RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL17 Protein, His-tagged
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Cat.#:IL17A-547HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL17A Protein (Ile20-Ala155), Met, Biotinylated
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Cat.#:IL17A-848MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IL17A Protein (Ala26-Ala158)
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Cat.#:IL17A-487HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 17A
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Cat.#:Il17a-489RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin-17A
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Cat.#:Il17a-492RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin-17AF Heterodimer
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Cat.#:IL17A&IL17F-165HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL17A/IL17F Protein, Biotinylated
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Cat.#:IL17A-122HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL17A
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Cat.#:IL17A-14153HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL17A, GST-tagged
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Cat.#:IL17A-166HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL17A Protein, Biotinylated
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Cat.#:IL17A-28212THTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL17A, Fc-tagged
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Cat.#:IL17A-288HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL17A, StrepII-tagged
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Cat.#:IL17A-307HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL17A
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Cat.#:IL17A-445HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL17A Protein, His-tagged
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Cat.#:IL17A-570HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 17A, MIgG2a Fc-tagged
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Cat.#:IL17A-571HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 17A, HIgG1 Fc-tagged, mutant
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Cat.#:IL17A-572HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Interleukin 17A, HIgG1 Fc-tagged
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Cat.#:IL17A-63HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IL17A, His-tagged
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Cat.#:IL17A-7334HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IL17A, His tagged
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Cat.#:IL17A-7335HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL17A, None tagged
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Cat.#:IL17A-870HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL17A protein, His & T7-tagged
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Cat.#:IL17A-97HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL-17A
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Cat.#:IL17A-001HTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Interleukin 17A, MIgG2a Fc-tagged
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Cat.#:Il17a-105MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il17a, None tagged
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Cat.#:Il17a-12MTag:N/A
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Il17a
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Cat.#:Il17a-334MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il17a, His-tagged
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Cat.#:IL17A-588MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Interleukin 17A, MIgG2a Fc-tagged, mutant
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Cat.#:Il17a-680RTag:
Source (Host):CHO cellsSpecies:Rat
Product nameRecombinant Rat Il17a
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Cat.#:Il17a-871RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il17a protein, His-tagged
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Cat.#:IL17A&IL17F-262RTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus IL17A/IL17F protein, His-tagged
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Cat.#:IL17A-261RTag:
Source (Host):Insect cellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus IL17A protein
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Cat.#:IL17A-168CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine IL17A
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Cat.#:IL17A-868DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog IL17A protein, His & T7-tagged
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Cat.#:IL17A-96CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine IL-17A
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Cat.#:IL17A-869CTag:His/GST
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken IL17A protein, His & GST-tagged
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Cat.#:IL17A-872RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL17A protein, His-tagged
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Cat.#:IL17A-153MTag:
Source (Host):E. coliSpecies:Marmoset
Product nameRecombinant Marmoset IL17A
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Cat.#:IL17A-425MTag:
Source (Host):E. coliSpecies:Marmoset
Product nameRecombinant Marmoset IL17A
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Cat.#:IL17A-98OTag:
Source (Host):YeastSpecies:Ovine
Product nameRecombinant Ovine IL-17A
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Cat.#:IL17A-333HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL17A
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Cat.#:IL17A-426HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 17A, His-tagged
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Cat.#:IL17A-113HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 17A
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Cat.#:IL17A-26HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-17
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Cat.#:IL17A-279HTag:Fc
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human Interleukin 17A, Fc Chimera
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Cat.#:Il17a-71MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 17A
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Cat.#:Il17a-89RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 17A
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Cat.#:IL17A-236BTag:N/A
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine Interleukin 17A
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Cat.#:IL17A-254ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine Interleukin 17A
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Cat.#:IL17A-001HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL17A cell lysate
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Cat.#:IL17A-4331HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL17A protein
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Cat.#:IL17A-5HTag:
Source (Host):Species:Human
Product nameHuman Interleukin-17 Reference standard
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Involved Pathway

IL17A involved in several pathways and played different roles in them. We selected most pathways IL17A participated on our site, such as Cytokine-cytokine receptor interaction, Inflammatory bowel disease (IBD), Rheumatoid arthritis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL17A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFB; TNFRSF6B; CCL13; CXCR7; TNFRSF25; IL17B; CCL21; IL1R2; LEP; AMHR2
Inflammatory bowel disease (IBD)
TLR4; IL18RAP; STAT3; Il4ra; TGFB3; TLR2; HLA-DMA; HLA-DRB3; H2-AA; HLA-DQB1
Rheumatoid arthritis
HLA-DQA1; CCL3; CD86; ATP6V0A4; HLA-DRB3; ATP6V0A1; VEGFA; CXCL6; CCL2; CCL5

Protein Function

IL17A has several biochemical functions, for example, cytokine activity, cytokine receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL17A itself. We selected most functions IL17A had, and list some proteins which have the same functions with IL17A. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein TNFSF9; CSF2; GM13288; IFNE; CCL38.1; CCL38A.4; TNFSF18; KITLG; FAM3C; WNT5A
Function cytokine receptor binding
Related Protein IFNT2; IFNPHI2; IFNPHI3; IL17C; IL17A/F3; Ifna11; IFNA14; IFNPHI4; IFNA12; IL21
Function protein binding
Related Protein ERC1; HSPBP1; PRR3; HSPB9; PLEC; CD79A; THOC1; GJD3; RAB33A; WDR20

Interacting Protein

IL17A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL17A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL17A.
DPH2

IL17A Related Articles

Mease, PJ; et al. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. CURRENT OPINION IN RHEUMATOLOGY 27:127-133(2015).
Ji, PY; Hu, HL; et al. AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. PARASITOLOGY RESEARCH 114:613-624(2015).

IL17A Related Gene Family

IL