tgfb1
Share
  • Official Full Name
  • Transforming Growth Factor, Beta 1
  • Background
  • Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene.
  • Synonyms
  • Tgfb1; transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; TGF-beta 1 protein; latency-associated peptide; Camurati-Engelmann disease; Transforming growth factor beta-1; TGF-beta-1; Camui Engelmann disease; Diaphyseal dysplasia 1 progressive; TGF beta 1; TGF beta; TGF beta 1 protein; TGF-beta-5; TGF-beta1; Tgfb-1; TGFB1_HUMAN; TGFbeta1; Transforming Growth Factor b1; Transforming Growth Factor beta 1; Transforming growth factor beta 1a
Cat.#:TGFb1-33MTag:
Source (Host):CHO cellsSpecies:Mouse
Product nameRecombinant Mouse TGF-beta 1 Protein
+Inquiry
Cat.#:TGFB1-363HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1 Protein, His & Avi-tagged, Biotinylated
+Inquiry
Cat.#:TGFB1-829BTag:His
Source (Host):E. coliSpecies:Bovine
Product nameRecombinant Bovine TGFB1 Protein (279-390 aa), His-tagged
+Inquiry
Cat.#:TGFB1-706HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:Tgfb1-1384RTag:His-SUMO
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tgfb1 Protein, His-SUMO-tagged
+Inquiry
Cat.#:TGFB1-1385CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TGFB1 Protein, His-tagged
+Inquiry
Cat.#:TGFB1-119HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 1, GST-tagged
+Inquiry
Cat.#:TGFB1-014HTag:
Source (Host):CHO cellSpecies:Human
Product nameRecombinant Human TGFB1 Protein
+Inquiry
Cat.#:TGFB1-057HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human TGFB1 Protein
+Inquiry
Cat.#:TGFB1-120HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1
+Inquiry
Cat.#:TGFB1-196HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1
+Inquiry
Cat.#:TGFB1-219HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1, MIgG2a Fc-tagged
+Inquiry
Cat.#:TGFB1-220HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1, HIgG4 Fc-tagged
+Inquiry
Cat.#:TGFB1-244HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1 protein, His-tagged
+Inquiry
Cat.#:TGFB1-3209HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1, His-tagged
+Inquiry
Cat.#:TGFB1-336HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1 protein, His-tagged
+Inquiry
Cat.#:TGFB1-345HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1 protein, His/MBP-tagged
+Inquiry
Cat.#:TGFB1-427HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1, Fc tagged
+Inquiry
Cat.#:TGFB1-428HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1
+Inquiry
Cat.#:TGFB1-429HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TGFB1 Protein, His-tagged
+Inquiry
Cat.#:TGFB1-4322HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TGFB1 protein, GST-tagged
+Inquiry
Cat.#:TGFB1-489HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1, His tagged
+Inquiry
Cat.#:TGFB1-509HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1, Fc-tagged
+Inquiry
Cat.#:TGFB1-518HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1
+Inquiry
Cat.#:Tgfb1-242MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tgfb1 protein, His-tagged
+Inquiry
Cat.#:Tgfb1-520MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tgfb1, His-tagged
+Inquiry
Cat.#:TGFB1-576MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tgfb1
+Inquiry
Cat.#:TGFB1-152RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tgfb1, His tagged
+Inquiry
Cat.#:TGFB1-153RTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TGFB1 protein
+Inquiry
Cat.#:Tgfb1-26RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tgfb1 Protein, His-tagged
+Inquiry
Cat.#:Tgfb1-531RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tgfb1 protein, His-tagged
+Inquiry
Cat.#:TGFB1-6035RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TGFB1 Protein
+Inquiry
Cat.#:TGFB1-1215CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TGFB1 Protein, His-tagged
+Inquiry
Cat.#:TGFB1-1051CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine TGFB1 Protein, His-tagged
+Inquiry
Cat.#:TGFB1-525DTag:His/GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog TGFB1 protein, His & GST-tagged
+Inquiry
Cat.#:TGFB1-526CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken TGFB1 protein, His-tagged
+Inquiry
Cat.#:TGFB1-532RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit TGFB1 protein, His & T7-tagged
+Inquiry
Cat.#:TGFB1-524CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TGFB1 protein, His & GST-tagged
+Inquiry
Cat.#:Tgfb1-527GTag:His/S
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Tgfb1 protein, His & S-tagged
+Inquiry
Cat.#:TGFB1-529STag:His/GST
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep TGFB1 protein, His & GST-tagged
+Inquiry
Cat.#:TGFB1-530PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig TGFB1 protein, His-tagged
+Inquiry
Cat.#:TGFB1-539HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1
+Inquiry
Cat.#:TGFB1-594HTag:N/A
Source (Host):Human PlateletsSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 1
+Inquiry
Cat.#:TGFB1-126HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, beta 1
+Inquiry
Cat.#:TGFB1-908HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Transforming Growth Factor, Beta 1, His-tagged
+Inquiry
Cat.#:TGFB1-21HTag:N/A
Source (Host):Species:Human
Product nameNative Human TGF- β1
+Inquiry
Cat.#:TGFB1-001HCLTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TGFB1 cell lysate
+Inquiry
Cat.#:TGFB1-2662HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TGFB1 cell lysate
+Inquiry
Cat.#:TGFB1-001MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TGFB1 cell lysate
+Inquiry
Cat.#:TGFB1-803RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TGFB1 cell lysate
+Inquiry
Cat.#:TGFB1-134HGTag:
Source (Host):CHO cellSpecies:Human
Product nameGMP Recombinant Human TGFB1 Protein
+Inquiry
Cat.#:TGFB1-159HGTag:
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human TGFB1 Protein
+Inquiry
Cat.#:TGFB1-95HTag:
Source (Host):Species:Human
Product nameHuman Transforming Growth Factor beta-1 (rDNA derived) Reference standard
+Inquiry
Cat.#:TGFB1-96BTag:
Source (Host):Species:Bovine
Product nameBovine Transforming Growth Factor beta-1 Reference standard
+Inquiry

Involved Pathway

Tgfb1 involved in several pathways and played different roles in them. We selected most pathways Tgfb1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tgfb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF11A; FGF11; RAC1A; MAP3K5; STK3; FGF1B; FAS; IKBKB; RAF1; RASA1
Cytokine-cytokine receptor interaction
CCL26; GM13305; TNFRSF1A; TNFRSF14; TNFRSF13C; BMP7B; IL18R1; CCR10; IL21R; Il23a
FoxO signaling pathway
CCNG2; PIK3CA; SGK1; CDKN2B; MAP2K2B; PRKAB1; GABARAPA; IGF1R; CCNB1; PRKAB2
Cell cycle
GADD45AB; ANAPC11; HDAC6; TEX12; ORC6L; GORASP2; DPF1; PDS5A; CDC20; CTDNEP1A
Endocytosis
SH3GLB2; HLA-G; CDC42L; DAB2; HSPA1A; GIT2A; LDLRAP1; RABEP1; STAMBP; SMAP1
TGF-beta signaling pathway
BMP7; SKP1; NOG3; RBX1; ZFYVE9; TGIF2; FST; INHBE; ACVR1L; LEFTY1
Osteoclast differentiation
FHL2; LILRB5; PIK3R2; NOX1; MAPK3; IFNG; AKT2; STAT2; CYLD; PIK3CA
Hippo signaling pathway
BTRC; BMPR1A; AJUBA; WNT9B; WNT5B; TGFBR2; NKD1; CRB1; SOX2; WWTR1
Intestinal i
CXCR4; HLA-DRB5; AICDA; CXCL12A; ITGB7; PIGR; CXCR4B; HLA-DRA; MHC2A; CCL25
ne network for IgA production
BLA; H2-AB1; HLA-DRB4; AICDA; MHC2A; TNFSF13; ICOS; HLA-DQA2; BLB2; CD40
Non-alcoholic fatty liver disease (NAFLD)
NDUFS8; NDUFA7; NDUFA10; PRKAG3; COX6B2; IL6; COX8C; COX7B2; NDUFB10; INS2
Leishmaniasis
RELA; C3; IL1B; IFNGR1; CR1; FCGR3B; MARCKSL1; Itgam&Itgb2; HLA-DPB1; HLA-DRB1
Chagas disease (American trypanosomiasis)
NOS2; CD3D; GNAL; CALR; CD247; PPP2R2C; GNAS; IL12A; CD3E; CD3D; TLR9
Malaria
TLR9; TNF; KLRB1; GYPC; CD40LG; CSF3; HBA1; HBB-B1; HBA2; GYPA
Toxoplasmosis
HLA-DRB1; CASP9; CYCS; HSPA1L; PPIF; H2-AB1; BIRC7; IKBKG; ITGA6; MAP2K3
Amoebiasis
COL4A1; IFNG; GNAL; PLCB1; MUC2; PRKCB; SERPINB3; RAB5B; C8G; SERPINB6B
Tuberculosis
CASP8; IL10RB; ATP6V1H; RAB5B; IL1A; IFNA2; TRAF6; HLA-DMB; RAB7A; H2-AB1
Hepatitis B
IFNB1; IFNA4; IFNA14; CREB3L3; VDAC3; STAT3; PIK3R2; Ifna11; TNF; CCNE2
HTLV-I infection
LCK; TBPL1; SMAD3; H2-Q10; MRAS; MAPK8; VDAC2; CCND2; PRKACA; PIK3CB
Pathways in cancer
RXRA; CUL2; KRAS; AKT2; FGF12; WNT6; IGF1R; LPAR5; CBLB; STAT1
Proteoglycans in cancer
SLC9A1; FZD5; ANK2; CBLC; CBLB; NANOG; DDX5; IL12B; GAB1; GRB2
Colorectal cancer
ARAF; BCL2; TGFB1; TCF7; TGFB2; BAX; CASP9; LEF1; RAC2; PIK3CA
Renal cell carcinoma
EGLN1; VEGFA; PTPN11; PIK3R5; PIK3CD; PIK3CA; RAP1A; TGFB3; PAK7; RAP1B
Pancreatic cancer
BRAF; TRP53; MAPK1; RALB; TGFB1; AKT2; MAP2K1; STAT3; RB1; TGFBR2
Chronic myeloid leukemia
BCR; BCL2L1; ARAF; ABL1; STAT5B; SHC1; TP53; PIK3R3; SHC3; PIK3CG
Inflammatory bowel disease (IBD)
IL1B; IL4R; IFNGR2; Il4ra; IL12A; TGFB2; HLA-DQA2; TLR5; RORC; H2-AB1
Rheumatoid arthritis
ATP6V0A1; Ctsl; ATP6V1C1; ATP6V0E1; HLA-DPB1; FOS; CXCL5; ATP6V1E2; ANGPT1; HLA-DQB1
Hypertrophic cardiomyopathy (HCM)
ITGA10; TNF; MYL2; TGFB3; PRKAA2; MYBPC3; SGCB; ITGB1; ITGA6; CACNA2D3
Dilated cardiomyopathy
TPM2; ITGA4; SGCA; ITGB3; LAMA2; ITGA6; ACTG1; ATP2A2; CACNA2D2; SGCB

Protein Function

Tgfb1 has several biochemical functions, for example, antigen binding, cytokine activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tgfb1 itself. We selected most functions Tgfb1 had, and list some proteins which have the same functions with Tgfb1. You can find most of the proteins on our site.
Function
Related Protein
Function antigen binding
Related Protein Ighg2a; LCK; IGKV1-5; IGKC; Ighg; KIR2DL3; LILRA2; IGLC2; FCN2; TGFB1
Function cytokine activity
Related Protein TNFSF15; SP100; SCG2; IL15; IFNA21; BMP7; ADIPOQ; IFNA12; TNF; NRG1
Function enzyme binding
Related Protein BIRC5; FOXO4; CYP2C19; BTG1; EIF2AK3; KPNB1; THRB; HNRNPUL1; LGALS9; PPP3CB
Function glycoprotein binding
Related Protein B2M; FBXO6; CDH1; HSPA5; Shh; LDLR; FOXRED2; BMPR1A; DNAJC5; ITGAM
Function growth factor activity
Related Protein INHA; BDNF; FGF12B; PDGFA; FGF20A; CTGF; IL11; LIF; INHBE; MSTN
Function protein N-terminus binding
Related Protein SCT; EIF3E; PPP1CC; KCNIP1; PDCD10; CHMP6; TGFB1; CSNK2A1; PDLIM5; MNAT1
Function protein binding
Related Protein GNAT1; GPA33; SNX27; PIN4; HFE2; ACO1; TRP63; SPTBN1; SAC3D1; LMNA
Function protein heterodimerization activity
Related Protein YWHAH; PRMT8; H2AFB3; CHRNB4; Itgam&Itgb2; CHRNB2; KATNA1; PVALB; ENO3; SDCBP
Function protein homodimerization activity
Related Protein MTERFD3; FGFR1OP; CREB3; SNX9; IRAK1; ENPP1; PRPS1; MYO7A; TARBP2; SLIT2
Function type I transforming growth factor beta receptor binding
Related Protein TGFBR2; SMAD2; SNX25; TGFB1; FKBP1A; TGFB3; ENG; SMAD7; SMAD6
Function type II transforming growth factor beta receptor binding
Related Protein TGFB1; TGFBR1; TGFB3; ENG; TGFB1A; TGFBR3; TGFB2; BAMBI
Function type III transforming growth factor beta receptor binding
Related Protein TGFB2; TGFB1; TGFBR2; TGFB3

Interacting Protein

Tgfb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tgfb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tgfb1.
TGFBR2; APP; MEOX2; 80125; FSTL1; THBS1; ENG

Tgfb1 Related Articles

Mrizak, D; Martin, N; et al. Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 107:-(2015).
Wang, YD; Rajanbabu, V; et al. Transcriptome analysis of medaka following epinecidin-1 and TH1-5 treatment of NNV infection. FISH & SHELLFISH IMMUNOLOGY 42:121-131(2015).

Tgfb1 Related Gene Family

TGF