IL3

  • Official Full Name

    interleukin 3

  • Overview

    The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

  • Synonyms

    Colony stimulating factor multiple;Hematopoietic growth factor;IL 3;IL-3;IL3;IL3_HUMAN;Interleukin 3 (colony stimulating factor, multiple);Interleukin 3;Interleukin-3;Mast cell growth factor;MCGF;MGC79398;MGC79399;Multi CSF;Multilineage colony stimulating factor;Multipotential colony stimulating factor;Multipotential colony-stimulating factor;OTTHUMP00000065963;P cell stimulating factor;P-cell-stimulating factor;BPA;PSF;HCGF;Csfmu;nterleukin-3;TTMUSP00000005831;ast cell growth factor

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Bovine
  • Cynomolgus
  • Chicken
  • Rhesus macaque
  • Dog
  • Canine
  • Insect Cells
  • HEK293
  • Nicotiana Benthamiana
  • CHO
  • E.coli
  • Mouse
  • Hordeum Vulgare
  • Yeast
  • N-His
  • Mammalian Cells
  • S.Cerevisiae
  • Human Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Non
  • Fc
  • Avi
  • HQ
  • GST
  • T7
  • MBP
Cat.# Product name Source (Host) Species Tag Protein Length Price
IL3-1093R Active Recombinant Rat IL3 Protein, His-tagged Insect Cells Rat His 1-169 a.a.
IL3-120H Active Recombinant Human Interleukin 3 (Colony-stimulating Factor, Multiple) HEK293 Human Non
IL3-145H Active Recombinant Human IL3, His-tagged, Animal Free Nicotiana Benthamiana Human His 20-152 a.a.
IL3-200H Active Recombinant Human IL3 CHO Human Non
IL3-436H Active Recombinant Human IL3 protein(Ala20-Phe152) E.coli Human Non Ala20-Phe152
IL3-503H Active Recombinant Human IL3 HEK293 Human Non 20-152 a.a.
Il3-592M Active Recombinant Mouse Interleukin 3 Mouse Mouse Non
Il3-644M Active Recombinant Mouse Il3 E.coli Mouse Asp33-Cys166
IL3-8862H Active Recombinant Human IL3, His-tagged Hordeum Vulgare Human Non
IL3-378H Recombinant Human IL3, His tagged Insect Cells Human His 1-152 a.a.
IL3-4369B Recombinant Bovine IL3 Protein Yeast Bovine Non 127aa
IL3-01HG Active GMP Recombinant Human IL3 Protein CHO Human
Il3-01M Active Recombinant Mouse Il3 Protein, His-Tagged E.coli Mouse His
IL3-0220C Active Recombinant Cynomolgus IL3 protein, His-tagged HEK293 Cynomolgus His 20-143 a.a.
IL3-075HG Active GMP Recombinant Human IL3 protein E.coli Human Non
IL3-1169M Recombinant Mouse IL3 protein(Met1-Cys166) HEK293 Mouse Non Met1-Cys166
IL3-1504C Recombinant Cynomolgus IL3 protein, His-tagged N-His Cynomolgus Ala20-Gln143
IL3-4316H Active Recombinant Human IL3 protein Yeast Human Non
IL3-455M Active Recombinant Mouse IL3 Protein HEK293 Mouse Non Met1-Cys166
IL3-6745H Recombinant Human IL3 protein, hFc-tagged HEK293 Human Fc Ala20-Phe152
IL3-7433H Recombinant Human IL3 protein, His-Avi-tagged E.coli Human Avi&His Ala20-Phe152
IL3-08H Recombinant Human IL3 protein E.coli Human Non 133
Il3-09M Recombinant Mouse Il3 protein E.coli Mouse Non 134
IL3-132H Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), His-tagged Insect Cells Human His
IL3-1556H Recombinant human IL3, Active, His-tagged Nicotiana Benthamiana Human His 20-152 a.a.
IL3-1734C Recombinant Chicken IL3 Mammalian Cells Chicken His
IL3-2250R Recombinant Rhesus monkey IL3 Protein, His-tagged Mammalian Cells Rhesus macaque His
IL3-275H Recombinant Human Interleukin 3 (Colony-Stimulating Factor, Multiple) S.Cerevisiae Human Non
IL3-362D Recombinant Dog Interleukin 3 (colony-stimulating factor, multiple) E.coli Dog Non
Il3-366M Recombinant Mouse Il3 Protein, His-tagged Insect Cells Mouse His
IL3-407D Recombinant Canine IL3 protein E.coli Canine Non 120
IL3-435H Active Recombinant Human IL3 protein(Met1-Phe152), His-tagged HEK293 Human His Met1-Phe152
IL3-539R Recombinant Rhesus IL3 protein E.coli Rhesus macaque Non 124
IL3-56H Recombinant Human IL3, His-tagged E.coli Human His 20-152 a.a.
Il3-576R Recombinant Rat Il3 protein E.coli Rat Non 144
Il3-591R Recombinant Rat Interleukin 3 E.coli Rat Non
IL3-604H Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), HQ-tagged Hordeum Vulgare Human HQ
IL3-639H Recombinant Human IL3 protein, His & GST-tagged E.coli Human GST&His Ala20~Phe152
Il3-640M Recombinant Mouse Il3 protein, His & T7-tagged E.coli Mouse His&T7 Asp33~Cys166
Il3-641M Recombinant Mouse Il3 protein, His & GST-tagged E.coli Mouse GST&His Asp33~Cys166
Il3-642R Recombinant Rat Il3 protein, His & T7-tagged E.coli Rat His&T7 Ile27~Cys166
Il3-643R Recombinant Rat Il3 protein, His & GST-tagged E.coli Rat GST&His Ile27~Cys166
IL3-88H Recombinant Human GMCSF/IL-3 Fusion Protein E.coli Human Non
ll3-542M Recombinant Mouse Iterleukin 3 Mouse Mouse Non
IL3-445RCL Recombinant Rat IL3 cell lysate Insect Cells Rat Non
IL3-607HCL Recombinant Human IL3 cell lysate Insect Cells Human Non
IL3-0221M Active Recombinant Mouse IL3 protein, His-tagged HEK293 Mouse His 27-166 a.a.
Il3-027I Active Recombinant Mouse Il3 Protein (135 aa) E.coli Mouse 135
IL3-065H Active Recombinant Human IL3 Protein E.coli Human 20-152 a.a.
IL3-077HG Active GMP Recombinant Human IL-3 protein HEK293 Human DNA sequence encoding Human IL-3 (GenBank: AAA59146.1) was expressed with His tag at the C-terminal.
IL3-07H Active Recombinant Human IL3 Protein, Pre-aliquoted E.coli Human Ala20-Phe152, with and without an N-terminal Met
IL3-097I Active Recombinant Human IL3 Protein (133 aa) E.coli Human 133
IL3-1035D Recombinant Dog IL3 Protein, His-tagged E.coli Dog His Arg24-Pro143
IL3-1036H Recombinant Human IL3 Protein, His-tagged HEK293 Human His Ala20-Phe152
Il3-1037R Recombinant Rat Il3 Protein, His-tagged HEK293 Rat His Ile27-Cys166
IL3-106H Human Interleukin-3 (rDNA derived) Reference standard Human Non
Il3-107M Active Recombinant Mouse Il3 Protein E.coli Mouse
Il3-108M Active Recombinant Mouse Il3 Protein E.coli Mouse 27-166 a.a.
Il3-114M Mouse Interleukin-3 (rDNA derived) Reference standard Mouse Non
IL3-131H Recombinant Human IL3 protein, His-Avi-tagged HEK293 Human Avi&His It contains Ala20-Phe152.
IL3-132HG GMP Recombinant Human IL3 protein E.coli Human Non 133
IL3-140H Recombinant Human IL3 Protein, Ala20-Phe152, N-His-Avi tagged, Biotinylated HEK293 Human Avi&His Ala20-Phe152
IL3-167H Active Recombinant Human IL3 Protein (Ala20-Phe152), C-His tagged, Animal-free, Carrier-free E.coli Human His Ala20-Phe152
IL3-168H Active Recombinant Human IL3 Protein E.coli Human
IL3-169M Active Recombinant Mouse IL3 Protein E.coli Mouse
IL3-170R Active Recombinant Rat IL-3β Protein E.coli Rat
IL3-187H Recombinant Active Human IL3 Protein, His-tagged(C-ter) E.coli Human His
Il3-188M Recombinant Active Mouse IL3 Protein, His-tagged(C-ter) E.coli Mouse His
Il3-1922H Recombinant Human Il3 Protein Insect Cells Human Non
IL3-2071R Recombinant Rhesus Macaque IL3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IL3-2071R-B Recombinant Rhesus Macaque IL3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IL3-246I Active Recombinant Human IL3 Protein CHO Human
Il3-247I Active Recombinant Rat Il3 Protein, His-tagged CHO Rat His
IL3-2481H Recombinant Human IL3 Protein (Ala20-Phe152), C-His tagged E.coli Human His Ala20-Phe152
IL3-248H Active Recombinant Human IL3 Protein E.coli Human Non
IL3-2600H Recombinant Human IL3 protein(41-130 aa), C-His-tagged E.coli Human His 41-130 aa
IL3-2601H Recombinant Human IL3 protein(41-130 aa), N-MBP & C-His-tagged E.coli Human His&MBP 41-130 aa
IL3-26HG Active Recombinant Human IL3 Protein (Ala20-Phe152), GMP Grade, Animal-Free E.coli Human Ala20-Phe152
IL3-3102H Recombinant Human IL3 protein, GST-tagged E.coli Human GST 20-152aa
IL3-32HG Recombinant Human IL3 Protein, GMP Grade, Animal-Free E.coli Human
Il3-355I Active Recombinant Rat Il3β Protein (144 aa) E.coli Rat 144
Il3-357I Active Recombinant Mouse Il3 Protein (135 aa) E.coli Mouse 135
IL3-358I Active Recombinant Human IL3 Protein (134 aa) E.coli Human 134
IL3-35H Active Recombinant Human IL3 Protein, Animal Free Human Cells Human
IL3-4276H Recombinant Human IL3 Protein (Met1-Phe152), C-His tagged Mammalian Cells Human His Met1-Phe152
IL3-4277H Recombinant Human IL3 Protein (Ala20-Phe152), C-His tagged Mammalian Cells Human His Ala20-Phe152
Il3-4681M Recombinant Mouse Il3 protein, His-tagged Yeast Mouse His
Il3-4682M Recombinant Mouse Il3 protein, His-tagged Yeast Mouse His
IL3-5192H Recombinant Human IL3 Protein, GST-tagged Wheat Germ Human GST
IL3-5760HF Recombinant Full Length Human IL3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 152 amino acids
Il3-58M Active Recombinant Mouse Il3 Protein (Asp33-Cys166), C-His tagged, Animal-free, Carrier-free E.coli Mouse His Asp33-Cys166
Il3-674M Recombinant Mouse Il3 protein, hFc-tagged HEK293 Mouse Fc Ala27-Cys166
Il3-7242M Active Recombinant Mouse Il3 Protein, His-tagged Insect Cells Mouse His 27-166
IL3-88M Recombinant Mouse IL3 Protein, His-tagged Human Cells Mouse His 27-166 a.a.

    Involved Pathway

    IL3 involved in several pathways and played different roles in them. We selected most pathways IL3 participated on our site, such as Cytokine-cytokine receptor interaction,PIK-Akt signaling pathway,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer HIST2H3C2,SMAD1,JMJD1C,ETV6,TLX3,DOT1L,PBX1,H3F3C,ELANE,KDM6A
    Fc epsilon RI signaling pathway PLCG1,MAP2K6,GRB2,MS4A2,RAC1,MAPK10,PLCG2,VAV1,KRAS,PIK3R5
    PIK-Akt signaling pathway YWHAZ,ITGA10,PRLR,EPO,SPP1,LPAR3,ITGA2B,Reln,F2R,Fasl
    Cytokine-cytokine receptor interaction BMPR1AA,CXCL11,BMPR2,TGFB1,LEPB,KITB,KITLG,Il6ra,CCL20B,IL1B
    Jak-STAT signaling pathway RAF1,Ifnlr1,SOCS5B,IL20RA,PIK3CG,IL20RB,RAF1A,HRAS,CCND1,IFNA14
    Hematopoietic cell lineage IL4R,EPOR,GP9,IL9R,HLA-DRA,IL11RA,Il4ra,CD34,DNTT,Fcer2a
    Asthma EPX,HLA-DMA,FCER1A,HLA-DQA2,IL5,HLA-DRB4,HLA-DPB1,CD40LG,HLA-DOA,IL13
    Apoptosis GZME,BCL2L11,MAP3K14,PRKACBA,HELLS,SPNA2,PPP3R1,HIST1H1E,HRK,CLSPN

    Protein Function

    IL3 has several biochemical functions, for example, cytokine activity,growth factor activity,interleukin-3 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL3 itself. We selected most functions IL3 had, and list some proteins which have the same functions with IL3. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-3 receptor binding RNF41
    growth factor activity FGF10,THBS4B,FGF3,VEGFAB,CSPG5,RABEP2,GDF9,FGF18A,OGN,TDGF1
    cytokine activity BMP4,OSM,FLT3LG,Ccl9,IL20,CCL19A.1,TXLNA,BMP3,Ifnl2,IL22

    Interacting Protein

    IL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL3.

    CSF2RB

    IL3 Related Signal Pathway

    Resources

    Gene Families

    Research Area

    References

    • Barr, TP; Kornberg, D; et al. Validation of endothelin B receptor antibodies reveals two distinct receptor-related bands on Western blot. ANALYTICAL BIOCHEMISTRY 468:28-33(2015).
    • Abrishami, M; Pastushok, L; et al. Synthetic Anti-IL3 Receptor Antibodies As Therapeutics to Block Innate Imatinib Resistance in Chronic Myelogenous Leukemia. BLOOD 124:-(2014).

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