il2
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  • Official Full Name
  • interleukin 2
  • Background
  • IL-2 is amember of a family of cytokines, which also includes IL-4, IL-7, IL-9, IL-15and IL-21. IL-2 signals through a receptor complex consisting of IL-2specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a commongamma chain (γc), which is shared by all members of this family of cytokines.Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Aktsignaling modules.
    IL-2 isnormally produced by the body during an immune response. When environmentalsubstances (molecules or microbes) gain access to the body, these substancesare recognized as foreign by antigen receptors that are expressed on thesurface of lymphocytes. Antigen binding to the T cell receptor (TCR)stimulates the secretion of IL-2, and the expression of IL-2 receptors IL-2R.The IL-2/IL-2R interaction then stimulates the growth, differentiation andsurvival of antigen-selected cytotoxic T cells via the activation of theexpression of specific genes. As such, IL-2 is necessary for the developmentof T cell immunologic memory, one of the unique characteristics of the immunesystem, which depends upon the expansion of the number and function ofantigen-selected T cell clones.
    IL-2 isalso necessary during T cell development in the thymus for the maturation ofa unique subset of T cells that are termed regulatory T cells (Tregs). Afterexiting from the thymus, T-Regs function to prevent other T cells fromrecognizing and reacting against "self antigens", which couldresult in "autoimmunity". T-Regs do so by preventing the respondingcells from producing IL-2. Thus, IL-2 is required to discriminate betweenself and nonself, another one of the unique characteristics of the immunesystem.
    IL-2 hasbeen found to be similar to IL-15 in terms of function. Both cytokines areable to facilitate production of immunoglobulins made by B cells and inducethe differentiation and proliferation of natural killer cells. The primarydifferences between IL-2 and IL-15 are found in adaptive immune responses.For example, IL-2 participates in maintenance of T-Regs and reducesselfreactive T cells. On the other hand, IL-15 is necessary for maintaininghighly specific T cell responses by supporting survival of CD8 memory Tcells.
  • Synonyms
  • IL-2; interleukin 2; TCGF; lymphokine; interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion; Il2; OTTMUSP00000007837; T-cell growth factor
Cat.#:IL2-22CTag:
Source (Host):YeastSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus Monkey IL-2 Protein
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Cat.#:IL2-1118HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2 Protein (Ala21-Thr153), Biotinylated
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Cat.#:IL2-311HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IL2 Protein (Ala 21 - Thr 153)
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Cat.#:IL2-445CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine IL2 Protein
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Cat.#:Il2-106MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il2 Protein
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Cat.#:IL2-1256RTag:His-SUMO/MYC
Source (Host):E. coliSpecies:Rhesus monkey
Product nameRecombinant Rhesus monkey IL2 Protein, His-SUMO/MYC-tagged
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Cat.#:IL2-4317FTag:
Source (Host):YeastSpecies:Ferret
Product nameRecombinant Ferret IL2 Protein
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Cat.#:IL2-464HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 2
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Cat.#:Il2-465MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 2
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Cat.#:IL2-134HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2 protein
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Cat.#:IL2-167HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2, MIgG2a Fc-tagged
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Cat.#:IL2-169HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2, HIgG1 Fc-tagged, mutant
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Cat.#:IL2-170HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2, HIgG1 Fc-tagged
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Cat.#:IL2-219HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2, StrepII-tagged
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Cat.#:IL2-25HTag:His
Source (Host):Barley grain (Hordeum vulgare)Species:Human
Product nameRecombinant Human IL2, His-tagged
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Cat.#:IL2-2741HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL2
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Cat.#:IL2-29HTag:
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human IL2 protein
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Cat.#:IL2-305HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2, Fc-tagged
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Cat.#:IL2-306HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human IL2, Fc-tagged
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Cat.#:IL2-473HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human IL2 protein, His-tagged
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Cat.#:IL2-501HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2, His tagged
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Cat.#:IL2-502HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2
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Cat.#:IL2-68HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL-2
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Cat.#:IL2-8861HTag:
Source (Host):Hordeum vulgareSpecies:Human
Product nameRecombinant Human Interleukin 2, His-tagged
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Cat.#:IL2-168HTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Human il2, MIgG2a Fc-tagged, mutant
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Cat.#:Il2-307MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Il2, Fc-tagged
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Cat.#:Il2-308MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il2, Fc-tagged
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Cat.#:IL2-333MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL2, MIgG2a Fc-tagged
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Cat.#:Il2-553MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Il2 protein, His-tagged
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Cat.#:Il2-637MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il2 protein, His & T7-tagged
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Cat.#:Il2-687MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il2
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Cat.#:IL2-955MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse IL2 Protein
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Cat.#:IL2-3038RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL2 Protein
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Cat.#:Il2-479RTag:His
Source (Host):HEK293FSpecies:Rat
Product nameRecombinant Rat Il2 protein, His-tagged
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Cat.#:Il2-575RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il2
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Cat.#:IL2-611RTag:Fc
Source (Host):CHOSpecies:Rat
Product nameRecombinant Rat Interleukin 2, HIgG1 Fc-tagged
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Cat.#:Il2-638RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il2 protein, His & GST-tagged
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Cat.#:Il2-747RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il2, None tagged
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Cat.#:IL2-616CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL2 Protein, His-tagged
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Cat.#:IL2-2242RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL2 Protein, His-tagged
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Cat.#:IL2-5729CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL2
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Cat.#:IL2-636CTag:His/S
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken IL2 protein, His & S-tagged
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Cat.#:IL2-699RTag:Met
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL2, Met-tagged
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Cat.#:IL2-260FTag:N/A
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline IL2 protein
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Cat.#:Il2-381CTag:Met
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Il2, Met-tagged
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Cat.#:IL2-600PTag:
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL2
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Cat.#:IL2-635CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL2 protein, His & T7-tagged
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Cat.#:IL2-672ETag:Met
Source (Host):E. coliSpecies:Equine
Product nameRecombinant Equine IL2, Met-tagged
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Cat.#:IL2-83PTag:
Source (Host):E. coliSpecies:Porcine
Product nameRecombinant Porcine IL2 Protein
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Cat.#:IL2-028ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2 (21-153aa), Met tagged
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Cat.#:IL2-341HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2
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Cat.#:IL2-376HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-2, His-tagged
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Cat.#:IL2-402HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-2 His Tag
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Cat.#:IL2-636HTag:HQ
Source (Host):Hordeum vulgare (barley grain)Species:Human
Product nameRecombinant Human Interleukin 2, HQ-tagged
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Cat.#:IL2-741HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human interleukin 2
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Cat.#:IL2-403MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin-2, His Tag
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Cat.#:ll2-538MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 2, His-tagged
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Cat.#:IL2-590CTag:N/A
Source (Host):COSSpecies:Chicken
Product nameRecombinant Chicken IL2
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Cat.#:IL2-06HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-2
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Cat.#:IL2-116HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 2
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Cat.#:Il2-94PTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 2
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Cat.#:IL2-249CTag:N/A
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken Interleukin 2
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Cat.#:IL2-255ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine Interleukin 2
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Cat.#:IL2-5234HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IL2 293 Cell Lysate
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Cat.#:IL2-152HGTag:His
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human IL2 Protein
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Cat.#:IL2-4317HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL2 protein
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Cat.#:IL2-80HTag:
Source (Host):Species:Human
Product nameHuman Interleukin- 2 (rDNA derived) Reference standard
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Cat.#:Il2-131MTag:
Source (Host):Species:Mouse
Product nameMouse Interleukin-2 (rDNA derived) Reference standard
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Cat.#:diphtheria toxin&IL2-P031HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2/diphtheria toxin, His-tagged therapeutic protein
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Cat.#:IL2-P044HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2 therapeutic protein
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Involved Pathway

IL2 involved in several pathways and played different roles in them. We selected most pathways IL2 participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
VEGFA; TNFSF15; MET; IL4R; IL22; ACVR2AA; IL24; CXCR3.1; IL22RA1; CCR1
PIK-Akt signaling pathway
IFNA21; TLR4; PIK3R3; COL6A6; GYS1; IFNAR1; RPS6; FGFR3; MLST8; IFNA1
Jak-STAT signaling pathway
CNTFR; MYCB; PIK3CA; OSMR; PIK3R3; FHL1A; IL28RA; Ifna15; SOCS1A; IFNGR2
T cell receptor signaling pathway
MAP2K1; Il2; NRAS; LCP2; CABIN1; PIK3CD; TEC; PTPN6; SOS1; IKBKB
Intestinal i
TNFRSF17; TNFSF13; CCL25B; CD40LG; HLA-DMA; BLB1; HLA-DPA1; IL4; CCL27B; ITGB7
ne network for IgA production
Icosl; IL6; CXCR4A; BLB2; CCL28; TNFRSF17; HLA-DMB; CD40; TNFSF13; MHC2A
Type I diabetes mellitus
HLA-C; HLA-DQB1; HLA-F; HLA-E; TNF; IL1A; Fasl; PRF1; HLA-DPB1; ICA1
Chagas disease (American trypanosomiasis)
NFKB1; IL1B; PIK3CA; AKT1; FADD; IFNG; GNAI2; TLR9; IFNB1; PPP2R2A
Measles
PIK3R3; IL12B; Ifna11; DDX58; IFNG; AKT2; IFNA2; SLAMF1; RCHY1; CBLB
HTLV-I infection
NRP1; IL6; SLC2A1; GPS2; CDC26; VAC14; HLA-DRB5; H2-AB1; HLA-DRB1; BUB1B
Autoi
HLA-C; H2-Q10; Il2; HLA-DMB; IFNA2; IFNA6; CD40; HLA-DMA; HLA-DQA2; IFNA4
ne thyroid disease
IFNA12; HLA-DPB1; CD40; HLA-E; IFNA10; HLA-B; FAS; IFNA5; IFNA13; CD40LG
Inflammatory bowel disease (IBD)
IFNGR2; FOXP3; IL12RB1; HLA-DPB1; IL2RG; H2-AB1; IL23; IL17A; HLA-DRA; IL21R
Allograft rejection
IL5; HLA-DRB4; PRF1; HLA-E; CD40; IL10; CD40LG; HLA-DRA; HLA-A; TNF
Graft-versus-host disease
TNF; HLA-DMA; HLA-DOB; Il2; HLA-DPB1; HLA-DQB1; KLRD1; HLA-DQA2; IL1A; FASLG

Protein Function

IL2 has several biochemical functions, for example, carbohydrate binding, cytokine activity, glycosphingolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2 itself. We selected most functions IL2 had, and list some proteins which have the same functions with IL2. You can find most of the proteins on our site.
Function
Related Protein
Function carbohydrate binding
Related Protein CLEC10A; FCNA; KLRC2; C15orf24; NCAN; SIGLEC14; Reg2; LGALS2A; KLRC3; KLRB1B
Function cytokine activity
Related Protein GDF15; TNFSF14; IL17B; CTF1; IL17F; GDF10; INHBB; CCL38A.5; GREM2; TNFSF12
Function glycosphingolipid binding
Related Protein LYN; SELL; LAMC1; SELP; Cel; LAMB1; LAMA1; Il2
Function growth factor activity
Related Protein COL20A1; THBS4; CSF1B; NRG4; IL9; MACC1; BTC; IL5; LFT2; CDNF
Function interleukin-2 receptor binding
Related Protein IL21; TIMM50; GATA3; ECM1; Il2
Function kappa-type opioid receptor binding
Related Protein Il2

Interacting Protein

IL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2.
Il2rg

IL2 Related Articles

Monzani, PS; Guemra, S; et al. MAC-T Cells as a Tool to Evaluate Lentiviral Vector Construction Targeting Recombinant Protein Expression in Milk. ANIMAL BIOTECHNOLOGY 26:136-142(2015).
Habibi, D; Shamsian, A; et al. Synthesis of pyranopyrazoles, benzopyrans, amino-2-chromenes and dihydropyrano[c]chromenes using ionic liquid with dual Bronsted acidic and Lewis basic sites. CHEMICAL PAPERS 69:586-595(2015).

IL2 Related Gene Family

IL