egfr
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  • Official Full Name
  • epidermal growth factor receptor
  • Background
  • The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
  • Synonyms
  • EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61
Cat.#:EGFR-024HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, APC labeled
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Cat.#:EGFR-024HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, R-PE labeled
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Cat.#:EGFR-102MATag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EGFR protein, Fc-tagged, APC labeled
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Cat.#:EGFR-102MPTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EGFR protein, Fc-tagged, R-PE labeled
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Cat.#:EGFR-1226RATag:Fc
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus EGFR protein, Fc-tagged, APC labeled
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Cat.#:EGFR-1226RPTag:Fc
Source (Host):HEK293Species:Rhesus
Product nameRecombinant Rhesus EGFR protein, Fc-tagged, R-PE labeled
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Cat.#:EGFR-28395THATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, APC labeled
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Cat.#:EGFR-28395THPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, R-PE labeled
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Cat.#:EGFR-288HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR Protein, His-Avi-tagged, Biotinylated
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Cat.#:EGFR-337HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFRvIII Protein (Leu 25 - Ser 645), His-tagged
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Cat.#:EGFR-338HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR Protein (Leu 25 - Ser 645), His-tagged, low endotoxin
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Cat.#:EGFR-339HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR Protein (Leu 25 - Ser 645), Fc-tagged
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Cat.#:EGFR-340HTag:Strep
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR Protein, Strep-tagged
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Cat.#:EGFR-341HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFRvIII Protein, His & Avi-tagged, Biotinylated
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Cat.#:EGFR-464HATag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, APC labeled
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Cat.#:EGFR-464HPTag:Fc
Source (Host):NS0 CellsSpecies:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, R-PE labeled
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Cat.#:EGFR-629HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, APC labeled
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Cat.#:EGFR-629HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, R-PE labeled
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Cat.#:EGFR-689HTag:HIgG1 Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EGFR Protein (Met1-Lys375) (Isoform vIII), HIgG1 Fc-tagged
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Cat.#:EGFR-690HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EGFR Protein (Met1-Lys375) (Isoform vIII), His-tagged
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Cat.#:EGFR-692HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, APC labeled
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Cat.#:EGFR-692HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Fc-tagged, R-PE labeled
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Cat.#:EGFR-1369HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR Protein, DDK-tagged
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Cat.#:EGFR-1373HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR Protein, His-tagged
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Cat.#:EGFR-1374ETag:His
Source (Host):E. coliSpecies:E.coli
Product nameRecombinant E. coli EGFR Protein, His-tagged
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Cat.#:EGFR-024HTag:Fc
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human EGFR Protein, Fc-tagged
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Cat.#:EGFR-025HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human EGFR Protein, His-tagged
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Cat.#:EGFR-155HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR Protein, His-tagged, Active
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Cat.#:EGFR-182HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR (C797S L858R) protein, GST-tagged, Active
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Cat.#:EGFR-183HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR(L858R) protein, GST-tagged, Active
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Cat.#:EGFR-184HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR(T790M C797S)protein, GST-tagged, Active
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Cat.#:EGFR-186HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR (T790M) protein, GST-tagged, Active
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Cat.#:EGFR-193HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, DDK/His-tagged
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Cat.#:EGFR-194HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, MYC/DDK-tagged
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Cat.#:EGFR-195HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, MYC/DDK-tagged
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Cat.#:EGFR-196HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR protein, His-tagged
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Cat.#:EGFR-197HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR protein, DDK-tagged
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Cat.#:EGFR-198HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ABCB5 protein, DDK-tagged
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Cat.#:EGFR-201HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human EGFR protein
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Cat.#:EGFR-202HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human EGFR Protein, His-tagged
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Cat.#:EGFR-206HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR, His-tagged
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Cat.#:EGFR-22HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGFR protein, His/T7-tagged
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Cat.#:EGFR-230HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR, StrepII-tagged
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Cat.#:EGFR-233HTag:Strep II
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EGFR, Strep-tagged
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Cat.#:EGFR-28392THTag:
Source (Host):Species:Human
Product nameRecombinant Human EGFR
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Cat.#:EGFR-28395THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human EGFR, Fc-tagged
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Cat.#:EGFR-28468THTag:
Source (Host):Species:Human
Product nameRecombinant Human EGFR
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Cat.#:EGFR-284HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR, His-tagged, Biotinylated
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Cat.#:EGFR-285HTag:His/AVI
Source (Host):Species:Human
Product nameRecombinant Human EGFR, His&Avi-tagged, Biotinylated
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Cat.#:EGFR-286HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, His-tagged
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Cat.#:EGFR-287HTag:Avi/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Avi/His-tagged, Biotinylated
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Cat.#:EGFR-30HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR, His tagged
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Cat.#:EGFR-31HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EGFR, His-GST tagged
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Cat.#:EGFR-33HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EGFR protein, GST-tagged
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Cat.#:EGFR-3803HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EGFR, His tagged
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Cat.#:EGFR-39HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EGFR Mutant (d747-752 P753S), GST-tagged
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Cat.#:EGFR-40HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EGFR Mutant (G719C), GST-tagged
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Cat.#:EGFR-41HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EGFR Mutant (G719S), GST-tagged
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Cat.#:EGFR-42HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human EGFR protein, Flag-tagged, Biotinylated
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Cat.#:EGFR-43HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human EGFR(T790M/L858R) protein, Flag-tagged, Biotinylated
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Cat.#:EGFR-463HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human EGFR
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Cat.#:EGFR-464HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human EGFR, Fc Chimera
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Cat.#:EGFR-55HTag:HIgG/His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human EGFR protein, hIgG-His-tagged
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Cat.#:EGFR-602HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human EGFR, Fc-tagged, Biotinylated
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Cat.#:EGFR-625HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, MYC/DDK-tagged
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Cat.#:EGFR-628HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, His-tagged
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Cat.#:EGFR-629HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR protein, Fc-tagged
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Cat.#:EGFR-692HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR, Fc Chimera
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Cat.#:EGFR-7629HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EGFR protein, His & S-tagged
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Cat.#:EGFR-P1001HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant HumanEpidermal Growth Factor Receptor
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Cat.#:EGFR-100MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EGFR Protein, His-tagged
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Cat.#:EGFR-101MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EGFR, His tagged
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Cat.#:EGFR-102MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EGFR, Fc tagged
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Cat.#:Egfr-202MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Egfr protein, His/S-tagged
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Cat.#:Egfr-5224MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Egfr, His-tagged
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Cat.#:Egfr-7630MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Egfr protein, His & T7-tagged
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Cat.#:Egfr-203RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Egfr protein, His/S-tagged
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Cat.#:Egfr-7433RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Egfr, His-tagged
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Cat.#:EGFR-60CTag:His
Source (Host):Insect cellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EGFR protein, His-tagged
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Cat.#:EGFR-61CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus EGFR protein, His-tagged
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Cat.#:EGFR-1226RTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus EGFR Protein, Fc-tagged
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Cat.#:EGFR-1227RTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus EGFR Protein, His-tagged
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Cat.#:EGFR-1228RTag:His
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus EGFR Protein, His-tagged
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Cat.#:EGFR-168CTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Canine
Product nameRecombinant Canine EGFR, His-tagged
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Cat.#:EGFR-7046CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken EGFR
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Cat.#:EGFR-297HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EGFR, GST-tagged, Active
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Cat.#:EGFR-29HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Epidermal Growth Factor Receptor
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Cat.#:EGFR-1211HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Epidermal Growth Factor Receptor, GST-tagged
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Cat.#:EGFR-1399HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EGFR (Active), GST-tagged
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Cat.#:EGFR-4753HTag:His
Source (Host):R1610Species:Human
Product nameRecombinant Human Epidermal Growth Factor Receptor, His-tagged
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Cat.#:EGFR-893HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Epidermal Growth Factor Receptor, Strep-tagged
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Cat.#:EGFR-2733HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human EGFR cell lysate
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Cat.#:EGFR-663HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EGFR cell lysate
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Cat.#:EGFR-1621MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse EGFR cell lysate
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Cat.#:EGFR-1462RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat EGFR cell lysate
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Cat.#:CSC-H0002Tag:
Source (Host):Species:Human
Product nameMouse Anti-Human EGFR Hybridoma
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Involved Pathway

EGFR involved in several pathways and played different roles in them. We selected most pathways EGFR participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adaptive Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with EGFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AGE/RAGE pathway
CHUK; EGFR; TIRAP; JUN; AGER; MAPK14; DIAPH1; DDOST; LGALS3; ATF2
ARMS-mediated activation
CRK; NTF7; DUSP5; DUSP1; CSF2RB; NRG2A; FGFR1B; DUSP4; PEA15A; DUSP6
Adaptive Immune System
KIF26A; ASB11; FGF10B; ASB10; AP2B1; GAN; SIGLEC12; CD300E; SIGLEC5; UFL1
Adherens junction
PVRL2; CSNK2A2A; AASS; ACTN3A; ACP1; SMAD3A; SMAD2; LMO7A; PTPN1; SRC
AhR pathway
EGFR; CYP1A2; AHR; NQO1; PTGES3; CDKN1B; CDKN1A; JUND; CYP1A1; AHRR
Alpha6-Beta4 Integrin Signaling Pathway
YWHAQ; CDKN1A; SMAD3B; EGFR; CD151L; RTKN; EIF4EBP1; PLEC; MST1R; DST
Androgen receptor signaling pathway
KAT7; CTNNB1; STUB1; EFCAB6; RNF4; SVILA; NR2C2; RAD9A; ETV5A; GNB2L1
Arf6 signaling events
IPCEF1; ADRB2; EGFR; USP6; EGF; ARAP2; GULP1; EFNA1; EPHA2; ADAP1

Protein Function

EGFR has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EGFR itself. We selected most functions EGFR had, and list some proteins which have the same functions with EGFR. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MAP2K2B; CMPK2; HSPA12B; DDX17; RPS6KA3; TRIO; CLK1; ABCA3; C10orf2; HSPA5
Function MAP kinase kinase kinase activity
Related Protein STK4; EGFR; MAP3K1; MAP3K14; MAP3K3; ALPK2; MAP3K13; TAOK1; STK3; MAP3K4
Function actin filament binding
Related Protein MYH9A; DBNL; ARPC1A; SCIN; ACTN1; TLN2A; SVIL; CTNNA2; MYO18A; TULP1
Function chromatin binding
Related Protein NCOA5; SIRT6; EGFR; ELK4; CITED2; FLI1; ZEB1; GATA5; NOC2L; CHD8
Function double-stranded DNA binding
Related Protein YBX1; LSM14A; MTERFD3; XRCC5; IFI203; XRCC3; EGFR; RAD51L3; SP8B; HES2
Function enzyme binding
Related Protein HNRNPUL1; PPP3CA; NR5A1; ATXN10; MDM2; HOXA9; SCN5A; SPDL1; MSH3; TMBIM6
Function epidermal growth factor-activated receptor activity
Related Protein EGFR; EFEMP1
Function identical protein binding
Related Protein DPP4; DES; CDC42; MCM10; MAP3K11; DRG1; USP4; EPOR; ZHX2; NCL
Function contributes_to nitric-oxide synthase regulator activity
Related Protein EGFR
Function protein binding
Related Protein ITGB7; EDC4; MAGEB6; KCTD6; CLDN18; RRM2; NLK; LRRC4C; C14orf169; NOXO1
Function protein heterodimerization activity
Related Protein MID2; SMAD4; CAV1; PRMT8; PANX1; HIST1H2AC; MYF5; TCF3; VAPB; HIST1H2BD
Function protein phosphatase binding
Related Protein JUP; MET; GNB2L1; FLT4; VCAN; LCK; AP3B1; TRAF3; TP53; GRB2
Function protein tyrosine kinase activity
Related Protein TYK2; FYN; TEK; DYRK1B; EGFRA; EGFR; KIT; RET; KIAA1804; DYRK2
Function receptor signaling protein tyrosine kinase activity
Related Protein SYK; ERBB3B; INSR; ERBB4A; EGFRA; KITB; ERBB4; EGFR; ERBB2; KIT
Function transmembrane receptor protein tyrosine kinase activity
Related Protein NTRK3; NTRK3A; ERBB4A; ERBB2; ALK; EPHB4A; TIE1; ROR1; IGF1RA; TYRO3
Function transmembrane signaling receptor activity
Related Protein TLR5; CD5; AGER; DARC; FZD7A; OR4D2; LEPR; EBP; TLR1; GHRHRL
Function ubiquitin protein ligase binding
Related Protein JKAMP; FLJ11011L; CKB; CCT2; MID1; SNCAIP; PIAS4; RNF20; UBE2N; BCL10

Interacting Protein

EGFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EGFR here. Most of them are supplied by our site. Hope this information will be useful for your research of EGFR.
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EGFR Related Articles

Fernandez-Ulibarri, I; Hammer, K; et al. Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity. INTERNATIONAL JOURNAL OF CANCER 136:2228-2240(2015).
Wang, YJ; Zhang, CL; et al. Investigation of phase SPR biosensor for efficient targeted drug screening with high sensitivity and stability. SENSORS AND ACTUATORS B-CHEMICAL 209:313-322(2015).