TNF Protein, tumor necrosis factor

TNF

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TNF

Official Full Name tumor necrosis factor
Background This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Synonyms TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin; APC1 protein; TNF, monocyte-derived; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2;
    • Species :
    • Bovine
    • Canine
    • Cattle
    • Cotton Rat
    • Cynomolgus Monkey
    • Dog
    • Equine
    • Ferret
    • Guinea Pig
    • Horse
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Sheep
    • Source :
    • Barley Grain
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Hordeum Vulgare
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • P.pastoris
    • Steptomyces lividans
    • Streptomyces Lividans
    • Yeast
    • Tag :
    • Alexa Fluor 488
    • Fc
    • FLAG
    • His
    • Avi
    • DDK
    • MBP
    • S
    • T7
    • HQ
    • Met
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNF-408H Recombinant Human TNF Protein, FLAG-tagged HEK293T FLAG
    Human TNF-63H Recombinant Human TNF Protein, FLAG-tagged E.coli FLAG
    Human TNF-001H Recombinant Human TNF Protein, His-tagged E.coli His
    Mouse Tnf-140M Recombinant Mouse Tnf Protein E.coli
    Human TNF-2001H Recombinant Human TNF Protein, His-tagged E.coli His
    Mouse Tnf-22M Recombinant Mouse Tnf Protein E.coli N/A
    Mouse Tnf-495M Recombinant Mouse Tnf Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Bovine TNF-716B Recombinant Bovine TNF Protein E.coli N/A
    Canine TNF-782C Recombinant Canine TNF protein E.coli N/A
    Mouse TNF-818M Recombinant Mouse TNF Protein (Leu80-Leu235), His-tagged, Biotinylated E.coli His
    Human DMABT-H19209 Mouse Anti-TNF Monoclonal Antibody Mouse Alexa Fluor 488
    Human TNF-106HG GMP Recombinant Human TNF Protein E.coli N/A
    Human TNF-1452H Recombinant Human TNF E.coli N/A
    Human TNF-154H Recombinant Human TNF protein HEK293 N/A
    Human TNF-171H Recombinant Human TNF Protein, Biotinylated E.coli N/A
    Human TNF-1914H Recombinant Human Tumor Necrosis Factor, HQ-tagged Hordeum Vulgare HQ
    Human TNF-194H Recombinant Human Tumor Necrosis Factor E.coli N/A
    Human TNF-213H Recombinant Human TNF, StrepII-tagged Human Cell Strep II
    Human TNF-234H Recombinant Human TNF Protein, Fc-tagged HEK293 Fc
    Human TNF-235H Recombinant Human TNF protein, His/S-tagged E.coli His/S
    Human TNF-241H Recombinant Human TNF protein, His/DDK-tagged HEK293 His/DDK
    Human TNF-242H Recombinant Human TNF protein E.coli N/A
    Human TNF-243H Recombinant Human TNF protein, His-tagged E.coli His
    Human TNF-244H Recombinant Human TNF protein, His-tagged E.coli His
    Human TNF-245H Recombinant Human TNF protein E.coli N/A
    Human TNF-246H Recombinant Human TNF protein E.coli N/A
    Human TNF-24H Recombinant Human Tumor Necrosis Factor alpha-1a E.coli N/A
    Human TNF-25H Recombinant Human Mutant Tumor Necrosis Factor Alpha E.coli N/A
    Human TNF-279H Recombinant Human TNF, Biotinylated HEK293 N/A
    Human TNF-30942TH Recombinant Human TNF N/A
    Human TNF-30945TH Recombinant Human TNF, His-tagged His
    Human TNF-3315H Recombinant Human TNF protein, His-tagged HEK293 His
    Human TNF-346H Recombinant Human TNF protein, His/MBP-tagged E.coli His/MBP
    Human TNF-347H Recombinant Human TNF protein, His/MBP-tagged E.coli His/MBP
    Human TNF-35H Recombinant Human TNF, His-tagged Barley Grain His
    Human TNF-361H Recombinant Human TNF protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human TNF-378H Recombinant Human Tumor Necrosis Factor HEK293 N/A
    Human TNF-379H Recombinant Human Tumor Necrosis Factor, His-tagged E.coli His
    Human TNF-38H Recombinant Human TNF protein E.coli N/A
    Human TNF-412H Recombinant Human TNF protein, FLAG-tagged HEK293 FLAG
    Human TNF-413H Recombinant Human TNF, Fc Chimera CHO Fc
    Human TNF-431H Recombinant Human TNF Yeast N/A
    Human TNF-4342HG GMP Recombinant Human TNF protein E.coli N/A
    Human TNF-43H Human Tumour Necrosis Factor alpha ( rDNA derived) Reference standard N/A
    Human TNF-511H Recombinant Human TNF protein, low endotoxin (HPLC-verified) HEK293
    Human TNF-72H Recombinant Human TNF, His-tagged E.coli N/A
    Human TNF-76H Recombinant Human Tumor Necrosis Factor-Alpha Variant, biologically active E.coli N/A
    Human TNF-897HCL Recombinant Human TNF 293 Cell Lysate HEK293 N/A
    Mouse TNF-1998M Recombinant Mouse TNF Protein E.coli N/A
    Mouse Tnf-236M Recombinant Mouse Tnf protein, His/S-tagged E.coli His/S
    Mouse Tnf-310M Recombinant Mouse Tumor Necrosis Factor Streptomyces Lividans N/A
    Mouse Tnf-331M Recombinant Murine Tumor Necrosis Factor Steptomyces lividans N/A
    Mouse Tnf-371M Recombinant Mouse Tumor Necrosis Factor Mouse N/A
    Mouse Tnf-484M Recombinant Mouse Tnf protein E.coli N/A
    Mouse Tnf-494M Recombinant Mouse Tnf protein, His-tagged HEK293F His
    Mouse Tnf-509M Recombinant Mouse Tnf Streptomyces Lividans N/A
    Mouse Tnf-533M Recombinant Mouse Tnf protein, His-tagged E.coli His
    Mouse Tnf-538M Recombinant Mouse Tnf protein, His-tagged HEK293F His
    Mouse TNF-64M Recombinant Mouse TNF-alpha Soluble, FLAG-tagged Flag
    Mouse Tnf-67M Recombinant Mouse Tnf protein, His-tagged Insect Cell His
    Rat TNF-1071R Recombinant Rat TNF Protein E.coli N/A
    Rat Tnf-108R Recombinant Rat Tnf, His-tagged E.coli His
    Rat Tnf-237R Recombinant Rat Tnf protein, His/S-tagged E.coli His/S
    Rat Tnf-381R Recombinant Rat Tnf P.pastoris N/A
    Rat Tnf-564R Recombinant Rat Tnf protein, His-tagged E.coli His
    Rat Tnf-577R Rat Tnfa Crystal Structure N/A
    Rat TNF-6193R Recombinant Rat TNF Protein Mammalian Cell His
    Rat Tnf-71R Recombinant Rat Tnf protein E.coli N/A
    Rat TNF-97R Recombinant Rat TNF, Flag-tagged E.coli Flag
    Cynomolgus Monkey TNF-1038C Recombinant Cynomolgus TNF Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey TNF-1168C Recombinant Cynomolgus TNF Protein E.coli N/A
    Rhesus TNF-1387R Recombinant Rhesus TNF protein E.coli N/A
    Rhesus Macaque TNF-4860R Recombinant Rhesus monkey TNF Protein, His-tagged Mammalian Cell His
    Rhesus monkey TNF-566R Recombinant Rhesus monkey TNF protein, His & T7-tagged E.coli His/T7
    Dog TNF-379D Recombinant Dog Tumor Necrosis Factor P.pastoris N/A
    Canine TNF-480C Recombinant Canine TNF, None tagged E.coli N/A
    Canine TNF-504C Recombinant Canine TNF, Met-tagged E.coli Met
    Dog TNF-558D Recombinant Dog TNF protein, His-tagged E.coli His
    Bovine TNF-378B Recombinant Bovine Tumor Necrosis Factor P.pastoris N/A
    Rabbit Tnf-311R Recombinant Rabbit TNF protein E.coli N/A
    Rabbit TNF-565R Recombinant Rabbit TNF protein, His & T7-tagged E.coli His/T7
    Rabbit TNF-668R Recombinant Rabbit TNF, Met-tagged E.coli Met
    Rabbit TNF-796R Recombinant Rabbit Tumor Necrosis Factor E.coli N/A
    Ferret TNF-1022F Recombinant Ferret TNF Protein E.coli N/A
    Guinea Pig Tnf-308P Recombinant Guinea Pig Tnf Yeast N/A
    Pig TNF-309P Recombinant Porcine Tumor Necrosis Factor E.coli N/A
    Pig TNF-33 Tumor necrosis factor alpha Fc-tagged HEK293 N/A
    Pig TNF-369S Recombinant Swine Tumor Necrosis Factor (TNF Superfamily, Member 2) Yeast N/A
    Equine TNF-380H Recombinant Horse Tumor Necrosis Factor P.pastoris N/A
    Cotton Rat Tnf-391C Recombinant Cotton Rat Tnf, Met-tagged E.coli Met
    Porcine TNF-5525P Recombinant Porcine Tumor Necrosis Factor E.coli N/A
    Cattle TNF-557C Recombinant Cattle TNF protein, His & T7-tagged E.coli His/T7
    Horse TNF-559H Recombinant Horse TNF protein, His & T7-tagged E.coli His/T7
    Sheep TNF-562S Recombinant Sheep TNF protein, His & T7-tagged E.coli His/T7
    Pig TNF-563P Recombinant Pig TNF protein, His-tagged E.coli His
    Equine TNF-666E Recombinant Equine TNF, Met-tagged E.coli Met
    Pig TNF-79P Recombinant Porcine Tumor Necrosis Factor-Alpha, biologically active E.coli N/A

    TNF involved in several pathways and played different roles in them. We selected most pathways TNF participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNB4; RPS6KA6; PPP3CCB; FGF6A; ATF4; FGF13; MAPKAPK3; PRKACB; PDGFRA; MECOM
    Cytokine-cytokine receptor interaction IL28RA; CXCR4; TNFRSF13C; Fasl; VEGFC; TGFBR1B; Ccl9; IFNPHI1; IFN-a; CRFB2
    NF-kappa B signaling pathway MAP3K7IP3; BIRC3; BCL2A1; GM13304; IL-8; CCL19; TRADD; TNFAIP3; CCL13; Bcl2a1b
    Sphingolipid signaling pathway MAPK11; LOC100328615; PIK3CA; NOS3; ROCK2; PIK3CB; ASAH2; MAPK12; S1PR2; PPP2R3A
    mTOR signaling pathway PRKCG; RRAGD; PTENA; CAB39; PTENB; ULK3; RHEB; PIK3CD; MAPK3; PRKCBA
    Apoptosis CAPN2B; PPP3CA; CASP2; ENDOG; CASP6; AKT1; DSG2; IRAK3; FASLG; DIABLOB
    TGF-beta signaling pathway ID2B; NBL1; PPP2R1B; THBS1; CUL1; BMP7B; BAMBIA; TGFBR1A; SMAD3A; RBX1
    Osteoclast differentiation PIK3CD; IL1R1; SPI1; MAPK3; SYK; CYLD; PPP3CA; NFATC2; LILRA1; cgr2b
    Antigen processing and presentation KLRC4; HSP90AB1; KIR3DL1; HSPA1A; HSP90AA1; HSPA4; HLA-DRB4; CD8B; KLRC3; HLA-B
    Toll-like receptor signaling pathway IFNA21; CXCL11; NFKBIA; IRF7; MAPK13; CD40; PIK3CG; IL8L1; RAC1B; AKT3A
    NOD-like receptor signaling pathway MAPK12A; RIPK2; TRAF6; NLRP1; HSP90AA1; PYCARD; CXCL2; IKBKG; HSP90AB1; MAPK8
    RIG-I-like receptor signaling pathway PIN1; MAPK10; IL8L2; MAPK12A; NT5C3; IFNA2; NFKBIAA; IL-8; MAPK14A; MAVS
    Hematopoietic cell lineage IL5RA; CD14; CD9; ITGAM; Fcer2a; GP9; IL11RA2; CD19; THPO; IL1R2
    Natural killer cell mediated cytotoxicity TNFRSF10C; VAV3; ICAM2; SAMD3; IFNA8; FCGR3; FYN; IFNGR2; GZMB; PLCG2
    T cell receptor signaling pathway CD8B1; NFATC1; CBLB; PAK7; PIK3R1; HRAS; BCL10; GRB2; CD8B; NFATC2
    Fc epsilon RI signaling pathway MAPK1; AKT1; PIK3R5; PLCG1; NRAS; VAV3; PLCG2; INPP5D; GM-CSF; GAB2
    TNF signaling pathway MAPK1; MAPK10; VEGFC; MAPK3; IL15; RIPK1; TRAF1; CREB3L1; MAP2K3; VCAM1
    Adipocytokine signaling pathway PCK1; PRKAG2A; CD36; NFKBIAA; JAK2; SOCS3B; PTPN11; RXRBA; AKT2L; ACSL3A
    Type II diabetes mellitus MAPK3; HK3; TNF; MAPK10; MAPK8; SOCS1; PIK3R5; HK2; PRKCD; PIK3R3
    Insulin resistance PRKAG3B; FOXO1B; CD36; PPP1CC; PYGMA; GYS2; MAPK8B; MAPK8A; PPP1R3A; PPARGC1A
    Non-alcoholic fatty liver disease (NAFLD) COX8C; IL1B; NDUFB6; NDUFA10; CEBPA; KCNA3; TRAF2; CYCS; NDUFA9; COX5A
    Type I diabetes mellitus HLA-DRB3; HLA-DRB5; GZMB; IL1A; HLA-DQA2; HLA-F; HLA-B; H2-Q10; HLA-DQA1; HLA-E
    Alzheimers disease NDUFA11; CALM4; Casp3; NDUFB8; SDHB; NDUFB6; NDUFA6; COX7B; CHP; mt-Atp8
    Amyotrophic lateral sclerosis (ALS) BAD; MAPK12; BAX; CCS; GRIA2; CASP12; DERL1; NEFH; TNF; PPP3CB
    Pertussis FOS; GNAI3; CALML5; CXCL5; SERPING1; IL6; NLRP3; IL23; LY96; Itgam&Itgb2
    Legionellosis CASP7; SAR1B; ITGB2; BNIP3; MYD88; HSPA2; HBS1L; CYCS; CASP1; EEF1A1
    Leishmaniasis IFNGR2; IL4; IRAK1; TLR4; TAB2; MAPK3; MAPK11; C3; NFKBIA; HLA-DRB4
    Chagas disease (American trypanosomiasis) MAPK1; NFKB1; CCL3; CD3D; RELA; Il2; MAPK8; CXCL8; NOS2; Fasl
    African trypanosomiasis F2RL1; HBB-B1; PRKCA; FAS; PLCB1; IFNG; HBA1; IL10; PLCB2; IL1B2
    Malaria THBS4; CSF3; SDC1; PECAM1; IL12A; ITGAL; HBB-B1; IL18; ICAM1; HBB
    Toxoplasmosis CASP9; TGFB1; BAD; HLA-DQB1; TNF; PPIF; IL12A; SOCS1; LAMB1; ITGA6
    Amoebiasis ITGAM; CD1d1; GNA11; SERPINB1C; LAMA4; C9; IFNG; CSF2; PRKACG; GNAS
    Tuberculosis FCGR3; KSR1; MAPK13; MAPK1; ARHGEF12; LSP1; PPP3CC; TLR2; FCGR2B; Cd209g
    Hepatitis C PIK3R3; CLDN5; CLDN1; IKBKG; AKT2; PPP2R2D; SOS1; TRAF2; PPP2R2B; OAS3
    Hepatitis B NFATC3; PIK3R3; RELA; GRB2; CCNA2; PRKCB; CASP10; ELK1; SMAD4; VDAC3
    Influenza A TYK2; IFNB; XPO1; IL18; PIK3CA; IL33; PIK3R5; IL1B; HLA-DRB3; MAPK3
    HTLV-I infection HLA-DMB; TNF; HLA-DPA1; RELB; DLG1; HLA-DQA1; IL2RG; NFATC3; HLA-DQB1; ICAM1
    Herpes simplex infection HLA-DQA2; UBE2R2; HCFC2; HLA-C; FADD; SFRS3B; IL12BA; SRSF7A; CYCS; C3
    Proteoglycans in cancer ANK2; ITGB3; ESR1; KRAS; PXN; HCLS1; RHOA; RPS6KB2; FGFR1; CDC42
    Asthma IL13; HLA-DQA2; HLA-DMA; IL5; IL9; HLA-DRB3; PRG2; CCL11; EPX; FCER1G
    Inflammatory bowel disease (IBD) HLA-DRA; STAT6; IFNG; RORC; HLA-DOB; IL1A; SMAD3; IL23; TLR4; IL12A
    Systemic lupus erythematosus HIST1H2AB; C8A; IFNG; H3F3B; HIST1H4N; FCGR4; HLA-DQA1; HIST1H3G; HIST1H4F; SSB
    Rheumatoid arthritis IL6; ATP6V0C; HLA-DQA2; TNFSF11; Il23a; VEGFA; H2-AA; ATP6V1C1; ATP6V0D1; ATP6V1E1
    Allograft rejection FAS; HLA-C; IL4; HLA-DRB5; HLA-B; IL10; GZMB; HLA-DRB3; Il2; HLA-E
    Graft-versus-host disease HLA-E; HLA-DRB3; IL1A; HLA-DRA; IFNG; KIR3DL1; HLA-DPA1; PRF1; GZMB; Fasl
    Hypertrophic cardiomyopathy (HCM) ITGB7; TPM3; ITGA2; TNNC1; PRKAG3; CACNG6; TNF; CACNA2D2; TGFB3; ITGA10
    Dilated cardiomyopathy PRKACG; TTN; MYBPC3; TGFB2; SGCB; TPM2; GNAS; ITGAV; MYL3; LAMA2

    TNF has several biochemical functions, for example, cytokine activity, identical protein binding, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNF itself. We selected most functions TNF had, and list some proteins which have the same functions with TNF. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity TNFSF14; IL13; SCGB3A1; IFNPHI3; GDF6; Kitl; IL17A; BMP8A; HMGB1A; IFNA14
    identical protein binding P2RX2; AMELX; TPRGL; DYNLT3; FAS; E2F7; COL7A1; VPS41; ACPP; USP2
    protease binding KIT; Serpina1b; ITGB1; SERPINE1; SERPINB6; LDLR; TNF; HSPD1; SERPINB9; SERPINA1A
    protein binding DYRK4; IFIT2; SERINC1; TLR13; RAP1A; PCP4; COL1A2; ILVBL; CLDN18; SHISA3
    transcription regulatory region DNA binding IKZF2; REST; MESP1; KDM1A; GATA3; MTERFD3; CITED1; NKX2; SALL1; FOXA3
    tumor necrosis factor receptor binding TNFSF13B; TNFSF10; TRIM37; FADD; CD40LG; TNFSF10L; TRAP1; TNFB; TNFSF15; BRE

    TNF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNF here. Most of them are supplied by our site. Hope this information will be useful for your research of TNF.

    TNFRSF1A; RIPK1; BIRC2; crmE

    Li, XY; Yue, Y; et al. Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis. MOLECULAR IMMUNOLOGY 65:177-188(2015).
    Lee, JS; Kwon, DS; et al. Mechanism of macrophage activation induced by polysaccharide from Cordyceps militaris culture broth. CARBOHYDRATE POLYMERS 120:29-37(2015).

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