Il6

  • Official Full Name

    interleukin 6

  • Overview

    This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]

  • Synonyms

    IL6;interleukin 6;HGF;HSF;BSF2;IL-6;IFNB2;interleukin-6;CDF;BSF-2;IFN-beta-2;interferon beta-2;interleukin BSF-2;interferon, beta 2;hybridoma growth factor;CTL differentiation factor;B-cell stimulatory factor 2;B-cell differentiation factor

Recombinant Proteins

  • Human
  • Cynomolgus
  • Rabbit
  • Atlantic Salmon
  • Mouse
  • Pig
  • Equine
  • Cotton Rat
  • Porcine
  • Chicken
  • Canine
  • Rhesus macaque
  • Zebrafish
  • Bovine
  • Rat
  • Dog
  • Macaca mulatta
  • Cat
  • Sheep
  • Ferret
  • Hamster
  • Horse
  • Guinea pig
  • Cattle
  • Llama
  • E.coli
  • Yeast
  • Mouse
  • HEK293
  • CHO
  • Nicotiana Benthamiana
  • Sf9 Cells
  • Barley Grain
  • Hordeum Vulgare
  • C-His
  • Insect Cells
  • Mammalian Cells
  • P.pastoris
  • Cat
  • Rabbit
  • Rat
  • Protein Conjugation
  • Human Cells
  • Non
  • His
  • Fc
  • HQ
  • GST
  • APC
  • Avi
  • DDK
  • Myc
  • Flag
  • mFc
  • SUMO
  • rFc
Cat.# Product name Source (Host) Species Tag Protein Length Price
IL6-12H Recombinant Human IL6 protein E.coli Human Non 183
IL6-326 Recombinant Cynomolgus Monkey IL6 protein Yeast Cynomolgus Non 185 aa
IL6-8849C Recombinant Cynomolgus IL6, None tagged E.coli Cynomolgus His 29-212 a.a.
IL6-02H Active Recombinant Human IL6 Protein (30-212aa), N-His-tagged E.coli Human His 30-212aa
IL6-037H-MAB Mouse Anti Human IL-6 Monoclonal Antibody, clone 77B11 (IVD grade) Mouse Human
IL6-038H-MAB Mouse Anti Human IL-6 Monoclonal Antibody, clone 84B7 (IVD grade) Mouse Human
IL6-040H Recombinant Human IL6 Protein, non-tagged, Biotinylated HEK293 Human Non 30-212 a.a.
IL6-113H Recombinant Human IL6 Protein (IVD grade) Human
IL6-4372R Recombinant Rabbit IL6 Protein Yeast Rabbit Non 188aa
IL6-4394A Recombinant Atlantic Salmon IL6 Protein Yeast Atlantic Salmon Non 202aa
IL6-001M Active Recombinant Mouse IL6, MIgG2a Fc-tagged CHO Mouse Fc 1-211 a.a.
IL6-041H Active Recombinant Human IL6 Protein HEK293 Human Non 30-212 a.a.
IL6-105H Active Recombinant Human IL6, His-tagged E.coli Human His 29-212 a.a.
IL6-106H Active Recombinant Human IL6 Nicotiana Benthamiana Human Non
IL6-128H Active Recombinant Human Interleukin 6 (Interferon, Beta 2) HEK293 Human Non
IL6-142H Active Recombinant Human IL6, His-tagged, Animal Free Nicotiana Benthamiana Human His 30-212 a.a.
Il6-16S Active Recombinant Swine Il6 Yeast Pig Non
IL6-1H Active Recombinant Human IL6 Sf9 Cells Human Non
IL6-23H Active Recombinant Human IL6 CHO Human Non
IL6-258E Active Recombinant Equine Interleukin 6 (Interferon, Beta 2) Yeast Equine Non
IL6-28H Active Recombinant Human IL6, His-tagged Barley Grain Human His
IL6-311H Active Recombinant Human IL6, MIgG2a Fc-tagged CHO Human Fc 30-212 a.a.
IL6-312H Active Recombinant Human IL6,HIgG1 Fc-tagged, mutant CHO Human Fc 30-212 a.a.
IL6-314H Active Recombinant Human IL6, MIgG2a Fc-tagged, mutant CHO Mouse Fc 1-211 a.a.
Il6-320M Active Recombinant Mouse Il6, Fc-tagged HEK293 Mouse Fc 25-211 a.a.
Il6-321M Active Recombinant Mouse Il6, Fc-tagged CHO Mouse Fc 1-211 a.a.
Il6-392C Active Recombinant Cotton Rat Il6, Met-tagged E.coli Cotton Rat 25-212 a.a.
Il6-657M Active Recombinant Mouse Il6 protein(Phe25-Thr211) E.coli Mouse Non Phe25-Thr211
IL6-8865H Active Recombinant Human IL6,His-tagged Hordeum Vulgare Human Non
IL6-01HG Active GMP Recombinant Human IL6 Protein CHO Human
Il6-01M Active Recombinant Mouse Il6 Protein, His-Tagged E.coli Mouse His
IL6-01P Active GMP Recombinant Porcine IL6 Protein, His-Tagged E.coli Porcine His
IL6-0299C Active Recombinant Cynomolgus IL6 protein, His-tagged HEK293 Cynomolgus His 28-212 a.a.
IL6-1500C Recombinant Cynomolgus IL6 protein, His-tagged C-His Cynomolgus Ala28-Met212
IL6-3395H Recombinant Human IL6 protein E.coli Human Non Val30-Met212
IL6-12C Recombinant Chicken IL6 Protein Yeast Chicken Non
IL6-597C Recombinant Chicken Interleukin 6 (interferon, beta 2), His-tagged E.coli Chicken His
IL6-1025P Active Recombinant Pig IL6 protein E.coli Pig Non Pro29-Met212
IL6-1112H Recombinant Human IL6 E.coli Human Non
Il6-12M Recombinant Mouse Il6 protein E.coli Mouse Non 188
IL6-144C Recombinant Canine IL6 protein, His-tagged Insect Cells Canine His 21-207 a.a.
IL6-1558H Recombinant human IL6, Active, His-tagged Nicotiana Benthamiana Human His 30-212 a.a.
IL6-2254R Recombinant Rhesus monkey IL6 Protein, His-tagged Mammalian Cells Rhesus macaque His
il6-23Z Recombinant Zebrafish il6 Protein Yeast Zebrafish Non
IL6-241B Active Recombinant Bovine Interleukin 6 (Interferon, Beta 2) Yeast Bovine Non
IL6-244C Recombinant Canine Interleukin 6 (Interferon, Beta 2) Yeast Canine Non
IL6-3049R Recombinant Rat IL6 Protein Mammalian Cells Rat His
IL6-318H Recombinant Human IL6, Fc-tagged CHO Human Fc 30-212 a.a.
IL6-323H Recombinant Human IL6, His-tagged E.coli Human His
IL6-363H Recombinant Human Interleukin 6 (interferon, beta 2) P.pastoris Human Non
Il6-37M Recombinant Mouse Il6 protein, His-tagged Insect Cells Mouse His
Il6-473R Recombinant Rat Il6 protein E.coli Rat Non 187
IL6-474P Active Recombinant Pig IL6 protein, His-tagged HEK293 Pig His
Il6-481R Active Recombinant Rat Il6 protein, His-tagged HEK293 Rat His
Il6-490M Recombinant Mouse Il6 protein, His-tagged HEK293 Mouse His Phe25~Thr211
IL6-498D Active Recombinant Dog IL6 Protein, His-tagged HEK293 Dog His Ala18~Met207
IL6-505H Recombinant Human IL6 protein HEK293 Human 183
IL6-5309H Recombinant Human Interleukin 6 (interferon, beta 2), HQ-tagged Hordeum Vulgare Human HQ
IL6-5433M Recombinant Macaca mulatta Interleukin 6 (interferon, beta 2) E.coli Macaca mulatta Non
IL6-554H Active Recombinant Human IL6 protein, His-tagged HEK293 Human His
Il6-558M Recombinant Mouse Interleukin 6 Mouse Mouse Non
IL6-560R Recombinant Rhesus IL6 protein E.coli Rhesus macaque Non 186
IL6-598C Recombinant Cat Interleukin 6 (interferon, beta 2) Cat Cat Non
IL6-6196C Recombinant Chicken IL6 Mammalian Cells Chicken His
IL6-654D Recombinant Dog IL6 Protein, His-tagged HEK293 Dog His
IL6-655S Recombinant Sheep IL6 protein, His-tagged E.coli Sheep His Gly30~Lys208
IL6-658R Recombinant Rabbit IL6 protein, His & GST-tagged E.coli Rabbit GST&His Phe27~Thr241
IL6-659R Recombinant Rhesus monkey IL6 protein, His-tagged E.coli Rhesus macaque His Pro27~Met212
IL6-78H Recombinant Human IL-6 Yeast Human Non
IL6-8236Z Recombinant Zebrafish IL6 Mammalian Cells Zebrafish His
Il6-8668M Recombinant Mouse Il6, None tagged E.coli Mouse Non 25-211 a.a.
IL6-8710R Active Recombinant Rat IL6 protein E.coli Rat Non Phe25-Thr211
IL6-5224HCL Recombinant Human IL6 293 Cell Lysate HEK293 Human Non
CAB11567RH Rabbit Anti-Human Interleukin 6 Monoclonal Antibody Rabbit Human Non
DMABT-H18984 Rat Anti-IL6 Monoclonal Antibody Rat Mouse APC
DMABT-H18985 Rat Anti-IL6 Monoclonal Antibody Rat Mouse Non
DMABT-H19252 Rat Anti-IL6 Monoclonal Antibody Rat Human APC
DMABT-H19253 Rat Anti-IL6 Monoclonal Antibody Rat Human Non
IL6-001H Recombinant Human IL6 Protein E.coli Human 29-212
IL6-002H Active Recombinant Human IL6 protein, His-tagged E.coli Human His
IL6-013F Recombinant Ferret IL6 Protein, Met1-Ile174, C-His tagged HEK293 Ferret His Met1-Ile174
IL6-018H Recombinant Hamster IL6 Protein, Met1-Asn212, C-His tagged HEK293 Hamster His Met1-Asn212
IL6-01SFL Recombinant Full Length Sheep IL6 Protein Yeast Sheep Non Full L.
Il6-024I Active Recombinant Mouse Il6 Protein (187 aa) E.coli Mouse 187
IL6-0300H Active Recombinant Human IL6 protein, Avi-His-tagged, Biotinylated HEK293 Human Avi&His 30-212 a.a.
IL6-0301M Recombinant Mouse IL6 protein, Avi-His-tagged, Biotinylated HEK293 Mouse Avi&His 25-211 a.a.
IL6-0302M Active Recombinant Mouse IL6 protein, His-tagged HEK293 Mouse His 25-211 a.a.
IL6-0339H Recombinant Human IL6 Protein (A28-M212), Tag Free E.coli Human Non A28-M212
Il6-044MG Active GMP Recombinant Mouse Il6 protein HEK293 Mouse DNA sequence encoding Mouse IL-6(NP_112445.1) was expressed with His tag at the C-terminal.
IL6-052H Recombinant Human IL6 Mutant (R44M) Protein, Myc/DDK-tagged HEK293 Human DDK&Myc
IL6-068H Active Recombinant Human IL6 Protein E.coli Human
Il6-076R Recombinant Rat interleukin 6 Protein, His&Flag tagged HEK293 Rat Flag&His 25-211aa
IL6-09H Active Recombinant Human IL6 Protein, Pre-aliquoted E.coli Human Pro29-Met212
IL6-100H Human Interleukin-6 (rDNA derived) Reference standard Human Non
IL6-1045D Active Recombinant Dog IL6 protein, His-tagged E.coli Dog His
IL6-1046H Recombinant Horse IL6 Protein, His-tagged E.coli Horse His Thr28-Met208
IL6-1047H Active Recombinant Human IL6 protein, GST-tagged E.coli Human GST
IL6-1048R Recombinant Rabbit IL6 Protein, His-tagged HEK293 Rabbit His Phe27-Thr241
IL6-1049P Active Recombinant Pig IL6 protein, His-tagged E.coli Pig His
Il6-1050G Recombinant Guinea pig Il6 Protein, His-tagged E.coli Guinea pig His Phe25-Asn223
IL6-1051C Recombinant Cattle IL6 Protein, His-tagged E.coli Cattle His Pro29-Lys208
IL6-1052C Recombinant Chicken IL6 Protein, His-tagged HEK293 Chicken His Gln87-Ala241
IL6-1053C Recombinant Chicken IL6 Protein, His-tagged E.coli Chicken His Gln87-Ala241
IL6-1105H Recombinant Human IL6 protein, His-tagged E.coli Human His 60-212 aa
Il6-113M Active Recombinant Mouse Il6 Protein E.coli Mouse
Il6-115M Recombinant Mouse Il6 Protein E.coli Mouse
Il6-116M Recombinant Mouse Il6 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
IL6-1179H Recombinant Human IL6 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
IL6-1179H-B Recombinant Human IL6 Protein Pre-coupled Magnetic Beads HEK293 Human
Il6-136M Mouse Interleukin-6 (rDNA derived) Reference standard Mouse Non
IL6-1584D Recombinant Dog IL6 Protein (Met1-Met207), C-His tagged E.coli Dog His Met1-Met207
IL6-1682H Recombinant Human IL6 Protein, His&GST-tagged E.coli Human GST&His Pro29-Met212
IL6-170H Active Recombinant Human IL6 Protein (Val30-Met212), C-His tagged, Animal-free, Carrier-free E.coli Human His Val30-Met212
Il6-176I Active Recombinant Rat Il6 Protein HEK293 Rat
Il6-183M Recombinant Mouse interleukin 6 Protein, Tag Free HEK293 Mouse Non 25-211aa
IL6-184H Active Recombinant Human IL6 Protein E.coli Human
IL6-185M Active Recombinant Mouse IL6 Protein E.coli Mouse
IL6-196H Active Recombinant Human IL6 Protein E.coli Human 30-212 a.a.
IL6-2075R Recombinant Rhesus Macaque IL6 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IL6-2075R-B Recombinant Rhesus Macaque IL6 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IL6-208H Recombinant Active Human IL6 Protein, His-tagged(C-ter) E.coli Human His
IL6-210H Recombinant Active Human IL6 Protein, Tag Free E.coli Human Non
IL6-210HG Active GMP Recombinant Human IL6 Protein E.coli Human 30-212 a.a.
IL6-211P Recombinant Active Pig IL6 Protein, His-tagged(C-ter) E.coli Pig His
IL6-213HG Active GMP Recombinant Human IL6 protein HEK293 Human
IL6-213P Active Recombinant Pig IL6 Protein (Arg31-Met212), C-His tagged, Animal-free, Carrier-free E.coli Pig His Arg31-Met212
Il6-214M Recombinant Mouse Il6 Protein, His-tagged E.coli Mouse His
IL6-22R GMP Recombinant Rhesus macaque IL-6 E.coli Rhesus macaque Non
IL6-2324H Recombinant Human IL6 Protein, His-tagged E.coli Human His Met1-Ala25+Val30-Met212
Il6-2325G Recombinant Guinea pig Il6 Protein, His-tagged HEK293 Guinea pig His Phe25-Asn223
IL6-236I Active Recombinant Human IL6 Protein CHO Human
Il6-237I Active Recombinant Mouse Il6 Protein, His-tagged CHO Mouse His
IL6-2493H Recombinant Human IL6 Protein (Met1-Met212), C-Fc tagged Mammalian Cells Human Fc Met1-Met212
IL6-24HG Active Recombinant Human IL6 Protein (Pro29-Met212), GMP Grade, Animal-Free E.coli Human Pro29-Met212
IL6-251H Recombinant Human IL6 Protein (Val30-Met212), C-mFc and 6×His-tagged HEK293 Human His&mFc Val30-Met212
IL6-2522H Active Recombinant Horse IL6 protein, His-tagged HEK293 Horse His
IL6-2704R Recombinant Rat IL6 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
IL6-2704R-B Recombinant Rat IL6 Protein Pre-coupled Magnetic Beads HEK293 Rat
IL6-2818C Recombinant Chicken IL6 Protein, His-tagged, OVA Conjugated Protein Conjugation Chicken His Asp54-Leu71
IL6-3106S Recombinant Sheep IL6 protein, GST-tagged E.coli Sheep GST 30-208aa
IL6-3219H Recombinant Horse IL6 protein, His-SUMO-tagged E.coli Horse His&SUMO Thr28~Met208
IL6-33HG Recombinant Human IL6 Protein, GMP Grade, Animal-Free E.coli Human
IL6-3576H Recombinant Human IL6 protein, His-tagged E.coli Human His 227aa(including fusion tag)
IL6-37H Active Recombinant Human IL6 Protein, Animal Free Human Cells Human
IL6-4285H Recombinant Human IL6 Protein (Met1-Met212), C-His tagged Mammalian Cells Human His Met1-Met212
IL6-4286H Recombinant Human IL6 Protein (Val30-Met212), C-His and Avi tagged Mammalian Cells Human Avi&His Val30-Met212
IL6-4321HG GMP Recombinant Human IL6 protein E.coli Human Non 183
IL6-44H Recombinant Human IL6 Protein E.coli Human Full L.
IL6-4654D Recombinant Dog IL6 protein, rFc-tagged HEK293 Dog rFc
IL6-515H Recombinant Human IL6 Protein, Biotinylated Human 212
IL6-516H Recombinant Human IL6 Protein Human 212
IL6-5451S Recombinant Sheep IL6 protein, His-tagged Yeast Sheep His 30-208aa
IL6-5814R Recombinant Rabbit IL6 protein, His-tagged Yeast Rabbit His 27-241aa
IL6-6017H Recombinant Human IL6 protein, His-tagged His 120-212 aa
IL6-6018H Recombinant Human IL6 protein, His-tagged His 1-212 aa
IL6-6019M Recombinant Mouse IL6 protein, His-tagged His 124-211 aa
IL6-606H Recombinant Human IL6 protein, His-tagged His 30-130 aa
IL6-61H Recombinant Human IL6 Protein E.coli Human -6 a.a.
Il6-61M Active Recombinant Mouse Il6 Protein (Phe25-Thr211), C-His tagged, Animal-free, Carrier-free E.coli Mouse His Phe25-Thr211
Il6-7246M Active Recombinant Mouse Il6 protein, His-tagged HEK293 Mouse His
IL6-732L Recombinant Llama IL6 protein, His-tagged E.coli Llama His 26-211a.a.
IL6-760HFL Recombinant Full Length Human IL6 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
IL6-96H GMP Recombinant Human IL6 E.coli Human Non
RPA3-2982H Recombinant Human RPA3 protein, His-tagged E.coli Human His 1-121 aa

    Involved Pathway

    Il6 involved in several pathways and played different roles in them. We selected most pathways Il6 participated on our site, such as Cytokine-cytokine receptor interaction,HIF- signaling pathway,FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Herpes simplex infection HCFC1,SRSF6,HLA-DMA,HNRNPK,C3A.3,DAXX,SRSF7,MHC1UEA,HLA-B,EP300
    Rheumatoid arthritis CXCL6,HLA-DMB,CD80,IL18,HLA-DQB1,TGFB1,ATP6V0D2,IFNG,FOS,IL1B
    Toll-like receptor signaling pathway CXCL8B.3,MAP3K7,MAP2K2,TLR9,MAP2K1,PIK3CG,CD80,SPP1,IFNA12,CCL4
    Malaria IL-8,ICAM1,TLR9,GYPB,THBS3,MET,ITGB2,KLRB1,Ccl12,SDC1
    Amoebiasis PRKCA,SERPINB13,PRKACG,C8B,IL12B,GNA11,IL1B2,COL4A3,CD14,NFKB1
    Inflammatory bowel disease (IBD) NFKB1,IFNG,IL17A,HLA-DMA,IL4R,HLA-DQB1,IL18RAP,IFNGR1,SMAD3,IL12B
    Intestinal i CXCL12A,HLA-DRB4,CXCL12B,BLA,ITGA4,MHC2DAB,CD40LG,CD28,CCR10,HLA-DRB5
    Cytosolic DNA-sensing pathway TMEM173,LOC100033925,POLR2L,ZBP1,IRF3,POLR2EB,MB21D1,MAVS,POLR2E,POLR3E
    HTLV-I infection ANAPC4,FZD2,PIK3CD,GM-CSF,WNT9B,H2-Q10,PDGFRB,NFKB2,ZFP36,ATF1

    Protein Function

    Il6 has several biochemical functions, for example, cytokine activity,growth factor activity,interleukin-6 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6 itself. We selected most functions Il6 had, and list some proteins which have the same functions with Il6. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-6 receptor binding PYCARD,ADAM17,CNTF,ERAP1
    cytokine activity NRG1,IL32,BMP2B,TSLP,ILTIFB,IFNA10,CSF1,CMTM1,IFNG1-2,GDF15
    growth factor activity PPBP,INHA,NRG4,GDF1,EREG,PRL2C3,TYMP,MDKB,LIF,IL4
    protein binding ABCG2,EXOSC4,BIK,CALU,PRDM1,METTL15,MCM2,HHIPL2,C11orf57,OGFR
    contributes_to interleukin-6 receptor binding Il6ra,IL6R,IL6ST

    Interacting Protein

    Il6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6.

    IL6R;ZBTB16;HRH1;IL6ST;SH3GL2

    Il6 Related Signal Pathway

    Resources

    Gene Families

    Research Area

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Il6 Products

    Required fields are marked with *

    My Review for All Il6 Products

    Required fields are marked with *