Recombinant Human IL5 protein, His-tagged
Cat.No. : | IL5-126H |
Product Overview : | Recombinant Human IL5(Ile20-Ser134) fused with His tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | IL-5 is expressed in eosinophils, NK cells, TC2 CD8+ T cells, mast cells, CD45+ CD4+ T cells, gamma delta T cells and IL-1 beta activated endothelial cells. IL-5 acts as a growth and differentiation factor for both B cells and eosinophils. Relative to B cells, IL-5 appears to induce the differentiation of activated conventional B-2 cells into Ig-secreting cells. In addition, it induces the growth of B-1 progenitors as well as IgM production by B-1 cells.IL-5 appears to perform a number of functions on eosinophils. These include the down modulation of Mac-1,the upregulation of receptors for IgA and IgG,the stimulation of lipid mediator (leukotriene C4 and PAF) secretion and the induction of granule release.IL-5 also promotes the growth and differentiation of eosinophils. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Protein length : | Ile20-Ser134 |
AA Sequence : | IPTEIPTSALVKETLALLSTHRTLL IANETLRIPVPVHKNHQLCTEEIFQ GIGTLESQTVQGGTV ERLFKNLSLIKKYIDGQKKKCGEER RRVNQFLDYLQEFLGVMNTEWIIES VDHHHHHH |
Endotoxin : | Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test. |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months. |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Shipping : | The product is shipped at ambient temperature. |
Gene Name : | IL5 interleukin 5 (colony-stimulating factor, eosinophil) [ Homo sapiens ] |
Official Symbol : | IL5 |
Synonyms : | IL5; interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5; B cell differentiation factor I; EDF; eosinophil differentiation factor; IL 5; interleukin 5; T cell replacing factor; TRF; T-cell replacing factor; B-cell differentiation factor I; IL-5; |
Gene ID : | 3567 |
mRNA Refseq : | NM_000879 |
Protein Refseq : | NP_000870 |
MIM : | 147850 |
UniProt ID : | P05113 |
Chromosome Location : | 5q23-q31 |
Pathway : | Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; |
Function : | cytokine activity; growth factor activity; interleukin-5 receptor binding; protein binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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