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In Face of Pancreatic Cancer

 Gene Database Associated with Pancreatic Cancer for Your Reference

 

Whenever talk about pancreatic cancer, people would feel scared. In China, pancreatic cancer is called as the king of all cancers due to its poor prognosis and short survival time. In developed countries, it is also a very troublesome issue. Now let’s see some statistics: about 44,000 people per year in the U.S. will be diagnosed with pancreatic cancer. And most of them will be over 65 years old. At the time of diagnosis, 52% of all patients have distant disease and 26% have regional spread. The relative 1-year survival rate for pancreatic cancer is only 26%, and the overall 5-year survival is 6%.

 

All cancer begins with a mutation in the DNA of one cell causing the cell to grow and divide uncontrollably. Environmental, rather than inherited, factors seem to cause the genetic mutations in most pancreatic cancers. But in some families, hereditary factors play an important role. While only about 10% of pancreatic cancers are considered familial or hereditary, pancreatic cancer researchers are interested in specific inherited genes. 

 

Here the following is the gene database associated with pancreatic cancer by alphabetic listing (only for education and reference purpose, not used in diagnosis or treatment):

 

S.No

Gene

Chromosome

Locus

1

ABCB1

7

7q21.1

2

ACVR1B

12

12q13

3

AGTR1

3

3q21-q25

4

AKT1

14

14q32.32

5

AKT2

19

19q13.1-q13.2

6

ALOX12

17

17p13.1

7

ALOX5

10

10q11.2

8

ALOX5AP

13

13q12

9

ANG

14

14q11.1-q11.2

10

ARHC

1

1p21-p13

11

ARMET

3

3p21.1

12

B3GALT5

21

21q22.3

13

BAG3

10

10q25.2-q26.2

14

BAG4

8

8p22

15

BAX

19

19q13.3-q13.4

16

BHLHB2

3

3p26

17

BIRC5

17

17q25

18

BRCA2

13

13q12.3

19

CCK

3

3p22-p21.3

20

CCKAR

4

4p15.1-p15.2

21

CCKBR

11

11p15.4

22

CCND3

6

6p21

23

CD44

11

11p13

24

CD9

12

12p13

25

CDH1

16

16q22.1

26

CDK4

12

12q14

27

CDKN1A

6

6p21.2

28

CDKN2A

9

9p21

29

CDKN2B

9

9p21

30

CLDN4

7

7q11.23

31

DAB2

5

5p13

32

DCC

18

18q21.3

33

DUSP6

12

12q22-q23

34

EGF

4

4q25

35

EGFR

7

7p12

36

EP300

22

22q13.2

37

EPHB2

1

1p36.1-p35

38

ERBB2

17

17q21.1

39

EREG

4

4

40

FGFR1

8

 8p11.2-p11.1

41

FHIT

3

3p14.2

42

FRAP1

1

1p36.3-p36.2

43

GAS

17

17q21

44

GLRX

5

5q14

45

GNG7

19

19p13.3

46

GPI

19

19q13.1

47

GUSB

7

7q21.11

48

HK2

2

2p12

49

HPSE

4

4q21.3

50

ID2

2

2p25

51

IL8

4

4q13-q21

52

IRS1

2

2q36

53

IRS2

13

13q34

54

KAI1

11

11p11.2

55

KRAS2

12

12p12.1

56

KRT20

17

*

57

MADH4

18

18q21.1

58

MADH6

15

15q21-q22

59

MAP2K4

17

17p11.2

60

MAP3K1

5

5

61

MAPK14

6

6p21.3-p21.2

62

MDM2

12

12q14.3-q15

63

MADH7

18

18

64

MEN1

11

11q13

65

MET

7

7q31

66

MMP11

22

22q11.23

67

MMP2

16

16q13-q21

68

MMP3

11

11q22.3

69

MMP7

11

 11q21-q22

70

MTA1

*

*

71

MUC1

1

1q21

72

MYC

8

8q24.12-q24.13

73

NFKB

**

**

74

NME1

17

17q21.3

75

NTRK1

1

1q21-q22

76

NTSR1

20

20q13-20q13

77

P8

16

*

78

PCD1

13

13q21.33

79

PLAUR

19

19q13

80

PPARG

3

3p25

81

PRG1

19

19q13.2

82

PRKCA

17

17q22-q23.2

83

PSCA

8

8q24.2

84

PTGS2

1

1q25.2-q25.3

85

RABIF

1

1q32-q41

86

RAD51

15

15q15.1

87

RB1

13

13q14.2

88

RELA

11

11q13

89

RNASE1

14

14

90

RPS6KB2

11

11cen-q12.1

91

SLC16A7

12

12q13

92

SCYB14

5

5q31

93

SDC1

2

2p24.1

94

SERPINB5

18

18q21.3

95

SERPINI2

3

3q26.1-q26.2

96

SLC2A1

1

1p35-p31.3

97

SPINT2

19

19q13.1

98

SST

3

3q28

99

STK11

19

19p13.3

100

TDG

12

12q24.1

101

TEM7

17

*

102

TFF1

21

21q22.3

103

TFF2

21

21q22.3

104

TGFA

2

2p13

105

TGFB1

19

19q13.1

106

TGFBR1

9

9q22

107

TGFBR2

3

3p22

108

TIMP1

x

xp11.3-p11.23

109

TJP1

15

15q13

110

TM4SF5

17

17p13.3

111

TMPRSS4

11

11q23.3

112

TNFRSF6

10

10q24.1

113

TP53

17

17p13.1

114

TSLC1

*

*

115

TXN

9

9q31

116

UCHL1

4

 4p14

117

VEGF

6

 6p12

118

VEGFC

4

4q34.1-q34.3

119

ZNF146

19

19q13.1

 

Tags: Pancreatic Cancer,  Gene Database,  Mutation,  Environmental Factors

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