In Face of Pancreatic Cancer

Gene Database Associated with Pancreatic Cancer for Your Reference

Whenever talk about pancreatic cancer, people would feel scared. In China, pancreatic cancer is called as the king of all cancers due to its poor prognosis and short survival time. In developed countries, it is also a very troublesome issue. Now let’s see some statistics: about 44,000 people per year in the U.S. will be diagnosed with pancreatic cancer. And most of them will be over 65 years old. At the time of diagnosis, 52% of all patients have distant disease and 26% have regional spread. The relative 1-year survival rate for pancreatic cancer is only 26%, and the overall 5-year survival is 6%.

All cancer begins with a mutation in the DNA of one cell causing the cell to grow and divide uncontrollably. Environmental, rather than inherited, factors seem to cause the genetic mutations in most pancreatic cancers. But in some families, hereditary factors play an important role. While only about 10% of pancreatic cancers are considered familial or hereditary, pancreatic cancer researchers are interested in specific inherited genes. 

Here the following is the gene database associated with pancreatic cancer by alphabetic listing (only for education and reference purpose, not used in diagnosis or treatment):

S.No	Gene	Chromosome	Locus
1	ABCB1	7	7q21.1
2	ACVR1B	12	12q13
3	AGTR1	3	3q21-q25
4	AKT1	14	14q32.32
5	AKT2	19	19q13.1-q13.2
6	ALOX12	17	17p13.1
7	ALOX5	10	10q11.2
8	ALOX5AP	13	13q12
9	ANG	14	14q11.1-q11.2
10	ARHC	1	1p21-p13
11	ARMET	3	3p21.1
12	B3GALT5	21	21q22.3
13	BAG3	10	10q25.2-q26.2
14	BAG4	8	8p22
15	BAX	19	19q13.3-q13.4
16	BHLHB2	3	3p26
17	BIRC5	17	17q25
18	BRCA2	13	13q12.3
19	CCK	3	3p22-p21.3
20	CCKAR	4	4p15.1-p15.2
21	CCKBR	11	11p15.4
22	CCND3	6	6p21
23	CD44	11	11p13
24	CD9	12	12p13
25	CDH1	16	16q22.1
26	CDK4	12	12q14
27	CDKN1A	6	6p21.2
28	CDKN2A	9	9p21
29	CDKN2B	9	9p21
30	CLDN4	7	7q11.23
31	DAB2	5	5p13
32	DCC	18	18q21.3
33	DUSP6	12	12q22-q23
34	EGF	4	4q25
35	EGFR	7	7p12
36	EP300	22	22q13.2
37	EPHB2	1	1p36.1-p35
38	ERBB2	17	17q21.1
39	EREG	4	4
40	FGFR1	8	8p11.2-p11.1
41	FHIT	3	3p14.2
42	FRAP1	1	1p36.3-p36.2
43	GAS	17	17q21
44	GLRX	5	5q14
45	GNG7	19	19p13.3
46	GPI	19	19q13.1
47	GUSB	7	7q21.11
48	HK2	2	2p12
49	HPSE	4	4q21.3
50	ID2	2	2p25
51	IL8	4	4q13-q21
52	IRS1	2	2q36
53	IRS2	13	13q34
54	KAI1	11	11p11.2
55	KRAS2	12	12p12.1
56	KRT20	17	*
57	MADH4	18	18q21.1
58	MADH6	15	15q21-q22
59	MAP2K4	17	17p11.2
60	MAP3K1	5	5
61	MAPK14	6	6p21.3-p21.2
62	MDM2	12	12q14.3-q15
63	MADH7	18	18
64	MEN1	11	11q13
65	MET	7	7q31
66	MMP11	22	22q11.23
67	MMP2	16	16q13-q21
68	MMP3	11	11q22.3
69	MMP7	11	11q21-q22
70	MTA1	*	*
71	MUC1	1	1q21
72	MYC	8	8q24.12-q24.13
73	NFKB	**	**
74	NME1	17	17q21.3
75	NTRK1	1	1q21-q22
76	NTSR1	20	20q13-20q13
77	P8	16	*
78	PCD1	13	13q21.33
79	PLAUR	19	19q13
80	PPARG	3	3p25
81	PRG1	19	19q13.2
82	PRKCA	17	17q22-q23.2
83	PSCA	8	8q24.2
84	PTGS2	1	1q25.2-q25.3
85	RABIF	1	1q32-q41
86	RAD51	15	15q15.1
87	RB1	13	13q14.2
88	RELA	11	11q13
89	RNASE1	14	14
90	RPS6KB2	11	11cen-q12.1
91	SLC16A7	12	12q13
92	SCYB14	5	5q31
93	SDC1	2	2p24.1
94	SERPINB5	18	18q21.3
95	SERPINI2	3	3q26.1-q26.2
96	SLC2A1	1	1p35-p31.3
97	SPINT2	19	19q13.1
98	SST	3	3q28
99	STK11	19	19p13.3
100	TDG	12	12q24.1
101	TEM7	17	*
102	TFF1	21	21q22.3
103	TFF2	21	21q22.3
104	TGFA	2	2p13
105	TGFB1	19	19q13.1
106	TGFBR1	9	9q22
107	TGFBR2	3	3p22
108	TIMP1	x	xp11.3-p11.23
109	TJP1	15	15q13
110	TM4SF5	17	17p13.3
111	TMPRSS4	11	11q23.3
112	TNFRSF6	10	10q24.1
113	TP53	17	17p13.1
114	TSLC1	*	*
115	TXN	9	9q31
116	UCHL1	4	4p14
117	VEGF	6	6p12
118	VEGFC	4	4q34.1-q34.3
119	ZNF146	19	19q13.1

 

Tags: Pancreatic Cancer,  Gene Database,  Mutation,  Environmental Factors

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