Cat. No.:	IL8-361H
Product Overview:	Human IL8 (P10145, 23 a.a. - 99 a.a.) partial recombinant protein expressed in Escherichia coli.
Description:	Interleukin-8 (IL8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene.
Sequence:	AVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS
Theoretical MW (kDa):	9
Form:	Lyophilized
Preparation Method:	E. coli expression system
Purity:	> 95% by SDS-PAGE and HPLC
Endotoxin Level:	< 0.1 ng/ug (1 EU/ug)
Activity:	Activity was determined by the ability to chemoattract human pheripheral blood monocytes was found to be in the range of 25.0-100.0 ng/mL.
Application:	SDS-PAGE
Storage Buffer:	Lyophilized from PBS, pH 7.0
Storage:	Store at -20°C on dry atmosphere. After reconstitution with deionized water, store at -20°C. Aliquot to avoid repeated freezing and thawing.
Unitprot ID:	P10145

Gene Name:	IL8 interleukin 8 [ Homo sapiens ]
Official Symbol:	IL8
Synonyms:	IL8; 3-10C; AMCF-I; CXCL8; Emoctakin; GCP-1; GCP1; IL-8; K60; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; SCYB8; TSG-1; b-ENAP; emoctakin; C-X-C motif chemokine 8; Granulocyte chemotactic protein 1; Monocyte-derived neutrophil chemotactic factor; Monocyte-derived neutrophil-activating peptide; Neutrophil-activating protein 1; Protein 3-10C; T cell chemotactic factor; T-cell chemotactic factor; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; interleukin 8; lymphocyte-derived neutrophil-activating factor; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; Interleukin-8
Gene ID:	3576
mRNA Refseq:	NM_000584
Protein Refseq:	NP_000575
MIM:	146930
Chromosome Location:	4q13-q21
Pathway:	Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Leukocyte transendothelial migration; Toll-like receptor signaling pathway; Signaling by GPCR
Function:	chemokine activity; interleukin-8 receptor binding; protein binding

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