Cat. No.: | IL8-361H |
Product Overview: | Human IL8 (P10145, 23 a.a. - 99 a.a.) partial recombinant protein expressed in Escherichia coli. |
Description: | Interleukin-8 (IL8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL8 in their storage vesicles, the Weibel-Palade bodies. In humans, the interleukin-8 protein is encoded by the IL8 gene. |
Sequence: | AVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS |
Theoretical MW (kDa): | 9 |
Form: | Lyophilized |
Preparation Method: | E. coli expression system |
Purity: | > 95% by SDS-PAGE and HPLC |
Endotoxin Level: | < 0.1 ng/ug (1 EU/ug) |
Activity: | Activity was determined by the ability to chemoattract human pheripheral blood monocytes was found to be in the range of 25.0-100.0 ng/mL. |
Application: | SDS-PAGE |
Storage Buffer: | Lyophilized from PBS, pH 7.0 |
Storage: | Store at -20°C on dry atmosphere. After reconstitution with deionized water, store at -20°C. Aliquot to avoid repeated freezing and thawing. |
Unitprot ID: | P10145 |
Gene Name: | IL8 interleukin 8 [ Homo sapiens ] |
Official Symbol: | IL8 |
Synonyms: | IL8; 3-10C; AMCF-I; CXCL8; Emoctakin; GCP-1; GCP1; IL-8; K60; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1; SCYB8; TSG-1; b-ENAP; emoctakin; C-X-C motif chemokine 8; Granulocyte chemotactic protein 1; Monocyte-derived neutrophil chemotactic factor; Monocyte-derived neutrophil-activating peptide; Neutrophil-activating protein 1; Protein 3-10C; T cell chemotactic factor; T-cell chemotactic factor; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; interleukin 8; lymphocyte-derived neutrophil-activating factor; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; Interleukin-8 |
Gene ID: | 3576 |
mRNA Refseq: | NM_000584 |
Protein Refseq: | NP_000575 |
MIM: | 146930 |
Chromosome Location: | 4q13-q21 |
Pathway: | Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Leukocyte transendothelial migration; Toll-like receptor signaling pathway; Signaling by GPCR |
Function: | chemokine activity; interleukin-8 receptor binding; protein binding |
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