"IL6R" Related Products

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Recombinant Human Interleukin 6 Receptor

Cat. No.: IL6R-545H
Product Overview: Recombinant human IL6Rwas expressed in HEK 293 cells and purified recombinant Human IL6R alphaprotein.
Description: IL6 mediates itsbiological effects through the type I IL6 receptor system that consists oftwo chains, IL6R and gp130. The IL6R chain is the binding component specificto IL6; while the gp130 only transmits signals of IL6 when bound to IL6R. Thegp130 also can transmit signals from LIF, OSM, CNTF, IL11 and CT-1 inconjunction with other receptor subunits. The low-affinity binding site forIL6 is composed of IL6R alone. IL6R is expressed in a wide range of cellsincluding T cells, fibroblasts and macrophages. Soluble IL6R which consistsof only the extracellular domain of the IL6R chain, acts as an agonist of IL6activity at low concentrations.
Source: Human
Host: HEK 293 cells
Form: Lyophilized from1xPBS. Reconstitute in 1XPBS to a concentration of 0.1-1.0 mg/ml. Whendissolved, dilute further into aqueous buffered solutions.
Purity: > 98% pure by SDSPAGE and HPLC
Sequence: Region of IL6Rprotein corresponding to amino acids LAPRRCPAQE VARGVLTSLP GDSVTLTCPGVEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQLSCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYIVSMCVASSVG SKFSK
Molecular Mass: 37.6 kDa
Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
Storage: Store at 4 deg Cuntil reconstitution. Following reconstitution aliquot and freeze at -20 degC for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol: IL6R
Gene Name: IL6Rinterleukin 6 receptor [ Homo sapiens ]
Synonyms: IL6R; interleukin 6 receptor;Interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; Membraneglycoprotein 80; gp80; CD126; IL-6R-1; MGC104991; OTTHUMP00000034320; CD126antigen
Gene ID: 3570
mRNA Refseq: NM_000565
Protein Refseq: NP_000556
MIM: 147880
UniProt ID: P08887
Chromosome Location: 1q21
Pathway: Cytokine Signalingin Immune system; Cytokine-cytokine receptor interaction; Hematopoietic celllineage; IL-6 Signaling Pathway; IL6-mediated signaling events; Immune System;Interleukin-6 signaling; Jak-STAT signaling pathway; SIDS SusceptibilityPathways; Senescence and Autophagy; Signaling by Interleukins
Function: ciliary neurotrophic factorbinding; ciliary neurotrophic factor receptor activity; enzyme binding;interleukin-6 receptor activity; interleukin-6 receptor binding; proteinhomodimerization activity; receptor activity; contributes_tointerleukin-6 receptor binding; protein binding

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