Recombinant Human Interleukin 28B (interferon, lambda 3)

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Recombinant Human Interleukin 28B (interferon, lambda 3)

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Cat. No. : IL28B-600H
Product Overview : Recombinant human IL28Bis expressed in human 293 cells with an apparent molecular mass of 24 kDa.This cytokine is produced in a serum-free, chemically defined media.Production in human 293 cells offers authentic human post-translationalmodification which contributes to stability in cell growth media and otherapplications. The purity is greater than 95%.
Description : IL28 is a cytokinethat comes in two isoforms, IL28A and IL28B, and plays a role in immunedefense against viruses, including the induction an antiviral state byturning on Mx proteins, 2",5"-oligoadenylate synthetase as well as ISGF3G(Interferon Stimulated Gene Factor 3). IL28A and IL28B belong to the type IIIinterferon family of cytokines and are highly similar (in amino acidsequence) to IL-29.
Source : HEK 293 cells
Species : Human
Purity : >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel was stainedwith Coomassie blue.
Molecular Mass : 24 kDa monomer,non-glycosylated.
Endotoxin Level : Endotoxin Free <1EU/μg
Biological Activity : 0.1 to 1 ng/mL ED50
Specific Activity : The specificactivity was determined by the dose dependent protection of the cytopathiceffect on A549 cells (human lung adenocarcinoma epithelial cell line) thatwere challenged with encephalomyocarditis (EMC) virus.
OfficialSymbol : IL28B
Pathways : Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway
Gene Name : IL28B interleukin 28B(interferon, lambda 3) [ Homo sapiens ]
Synonyms : IL28B;interleukin 28B (interferon, lambda 3); IFNL3; IL28C; IL-28B; interleukin-28B;IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28C;cytokine Zcyto22; interferon lambda-3; interferon lambda-4; interferon,lambda 3; interferon, lambda 4; Interleukin-28B; Interferon lambda-4; Cytokine Zcyto22; Interferon lambda-3; Interleukin-28C
Gene ID : 282617
mRNA Refseq : NM_172139
Protein Refseq : NP_742151
MIM : 607402
UniProt ID : Q8IZI9
Chromosome Location : 19q13.13
Function : cytokine activity

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