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Recombinant Mouse Il1f5

Cat.No.: Il1f5-553M
Product Overview: Recombinant Mouse Il1f5 produced in E. coli is approximately 16.9 kDa, a single non-glycosylated polypeptide chain containing 154 amino acids.
Description: Interleukin-36 receptor antagonist (IL-36RA) is a secreted protein which belongs to the interleukin 1 cytokine family (IL-1 family) and it is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes.IL-36RA has been reported to antagonize the biological activity of IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). Furthermore, it could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1). In addition, The receptor for IL-36RA has not been positively identified. Indirect evidence suggests it is IL-1Rrp2. Recombinant murine interleukin-36 RA contains 154 amino acid residues and it shares 91 % a.a. sequence identity with human IL-36RA.
Source: E. coli
Species: Mouse
Form: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, 2mM β-mercaptoethanol.
Bio-activity: Fully biologically active when compared to standard. The ED 50 determined by inhibiting IL-36 beta induced IL-6 secretion by murine NIH/3T3 cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/mg in the presence of 20 ng/ml of recombinant murine IL-36 beta.
Molecular Mass: 16.9 kDa
AA Sequence: VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
Endotoxin: Less than 1 EU/μg of rMuIL-36RA as determined by LAL method.
Purity: >95% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: Il1f5 interleukin 1 family, member 5 (delta) [ Mus musculus ]
Official Symbol: Il1f5
Synonyms: IL1F5; interleukin 1 family, member 5 (delta); interleukin-36 receptor antagonist protein; IL-1F5; IL-1L1; IL-1HY1; IL-1 delta; interleukin-1 HY1; interleukin-1 delta; interleukin-1 homolog 3; interleukin-1-like protein 1; interleukin-1 family member 5; interleukin 1 receptor antagonist homolog 1; IL36RN; Il-1h3; Il1hy1; AI413231; Fil1delta;
Gene ID: 54450
mRNA Refseq: NM_001146087
Protein Refseq: NP_001139559
Function: cytokine activity; interleukin-1 receptor antagonist activity; molecular_function;

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