Active Recombinant Human IL4 (25-153aa), Met tagged
Cat.No. : | IL4-030E |
Product Overview : | Recombinant Human IL4 (His25 Ser153, with an Nterminal Met) was expressed in E. coli and produced using nonanimal reagent in an animalfree laboratory. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL4-030E |
Description : | Interleukin4 (IL4), also known as B cellstimulatory factor1, is a monomeric, approximately 13 kDa 18 kDa Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four μhelix structure. IL4 is primarily expressed by Th2biased CD4+ T cells, mast cells, basophils, and eosinophils . It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL4 plays a dominant role in the development of allergic inflammation and asthma. |
Source : | E. coli |
Nterminal Sequence Analysi : | Met |
Molecular Mass : | 14 kDa |
Activity : | Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The ED50 for this effect is typically 0.05 0.2 ng/mL. |
Endotoxin Leve : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >97%, by SDSPAGE under reducing conditions and visualized by silver stain. |
Formulation : | Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Storage : | Use a manual defrost freezer and avoid repeated freezethaw cycles. 1. 12 months from date of receipt, 20 to 70 °C as supplied. 2. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3. 3 months, 20 to 70 °C under sterile conditions after reconstitution. |
Unitprot ID : | P05112 |
Gene Name : | IL4 interleukin 4 [ Homo sapiens ] |
Official Symbol : | IL4 |
Synonyms : | IL4; interleukin 4; BSF1; IL-4; BCGF1; BSF-1; BCGF-1; MGC79402; interleukin-4; binetrakin; pitrakinra; B cell growth factor 1; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1 |
Gene ID : | 3565 |
mRNA Refseq : | NM_000589 |
Protein Refseq : | NP_000580 |
MIM : | 147780 |
Chromosome Location : | 5q31.1 |
Pathway : | CD40/CD40L signaling; Calcium signaling in the CD4+ TCR pathway; Fc epsilon RI signaling pathway; IL-4 signaling Pathway; Jak-STAT signaling pathway; T cell receptor signaling pathway; Notch signaling pathway |
Function : | cytokine activity; growth factor activity; interleukin-4 receptor binding; protein binding |
Products Types
◆ Recombinant Protein | ||
IL4-0017H | Recombinant Human IL4 Protein | +Inquiry |
IL4-2702R | Recombinant Rat IL4 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL4-1040R | Recombinant Rabbit IL4 Protein, His-tagged | +Inquiry |
IL4-203H | Recombinant Active Human IL4 Protein, His-tagged(C-ter) | +Inquiry |
Il4-2319G | Recombinant Guinea pig Il4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL4-001MCL | Recombinant Mouse IL4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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