"IL8" Related Products

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Recombinant Porcine interleukin 8(aa 1-72)

Cat. No.: IL8-231P
Product Overview: Interleukin-8 Porcine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 72 amino acids and having a molecular mass of 8291 Dalton. The IL-8 is purified by proprietary chromatographic techniques.
Description: Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation.
Source: Porcine
Host: Escherichia Coli.
Form: Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC; (b) Analysis by SDS-PAGE.
Bio-activity: The biological activity of IL8 was determined by the dose dependent mobilization of intracellular calcium (calcium flux) with human neutrophils and was found to be >1.0 ng/mL.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility: It is recommended to reconstitute the lyophilized Interleukin-8 in sterile 18Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Amino acid sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Ala-Lys-Glu-Leu.
Protein content: Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm using the absorbency value of 0.85 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of IL-8 as a Reference Standard.
Storage: Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL8 should be stored at 4°C between 2~7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: IL8 interleukin 8 [ Sus scrofa ]
Official Symbol: IL8
Synonyms: IL-8; 3-10C; AMCF-I; CXCL8; GCP-1; MDNCF; Monocyte-derived neutrophil chemotactic factor; GCP1; T-cell chemotactic factor; Neutrophil-activating protein 1; NAP-1; Protein 3-10C; Granulocyte chemotactic protein 1; Monocyte-derived neutrophil-activating peptide; MONAP; Emoctakin; K60; NAF; LECT; LUCT; LYNAP; SCYB8; TSG-1; b-ENAP; NAP1; C-X-C motif chemokine 8; Interleukin-8 precursor; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; lymphocyte-derived neutrophil-activating factor; small inducible cytokine subfamily B member 8; interleukin 8
Gene ID: 396880
mRNA Refseq: NM_213867
Protein Refseq: NP_999032
MIM: 146930
UniProt ID: P26894
Chromosome Location: 4q13-q21
Pathway: Bladder cancer; Chemokine signaling pathway; Cytokine-cytokine receptor interaction; NOD-like receptor signaling pathway; Pathways in cancer; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway

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