"IL2" Related Products

Recombinant Human IL2, HIgG1 Fc-tagged

Cat.No.: IL2-170H
Product Overview: The extracellular domain of human IL-2(NP_000577.2)(Ala21-Thr153) (Cys145Ser) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
Description: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and Blymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also sharedby interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic,which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeteddisruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential roleof this gene in the immune response to antigenic stimuli
Source: CHO cells
Species: Human
Tag: HIgG1 Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells.
Molecular Mass: 44KDa (monomer)
AA Sequence: (Ala21-Thr153) (Cys145Ser)
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: IL2 interleukin 2 [ Homo sapiens ]
Official Symbol: IL2
Synonyms: IL2; interleukin 2; interleukin-2; IL 2; T cell growth factor; TCGF; aldesleukin; involved in regulation of T-cell clonal expansion; IL-2; lymphokine;
Gene ID: 3558
mRNA Refseq: NM_000586
Protein Refseq: NP_000577
MIM: 147680
UniProt ID: P60568
Chromosome Location: 4q26-q27
Pathway: Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem;
Function: carbohydrate binding; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding; kinase activator activity;

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