Active Recombinant Mouse Il33, His-tagged
Cat.No. : | Il33-358M |
Product Overview : | Mouse IL-33 (aa 109-266) is fused at the C-terminus to a His-tag. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Liquid. 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. |
Bio-activity : | Activates human ST2-dependent NF-κB pathway. |
Molecular Mass : | ~20kDa (SDS-PAGE) |
Purity : | ≥90% (SDS-PAGE) |
Stability : | Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Gene Name : | Il33 interleukin 33 [ Mus musculus ] |
Official Symbol : | Il33 |
Synonyms : | IL33; interleukin 33; interleukin-33; nuclear factor from high endothelial venules; Il-33; Il1f11; NF-HEV; 9230117N10Rik; |
Gene ID : | 77125 |
mRNA Refseq : | NM_001164724 |
Protein Refseq : | NP_001158196 |
Pathway : | Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; |
Function : | cytokine activity; cytokine activity; cytokine activity; |
Products Types
◆ Recombinant Protein | ||
Il33-192M | Recombinant Active Mouse IL33 Protein, His-tagged(C-ter) | +Inquiry |
IL33-2313H | Recombinant Human IL33 Protein, His-tagged | +Inquiry |
Il33-157M | Recombinant Mouse Il33 Protein | +Inquiry |
IL33-45H | Recombinant Human IL33 Protein, N-Avi tagged, Biotinylated | +Inquiry |
IL33-5188H | Recombinant Human IL33 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
IL33-5226HCL | Recombinant Human IL33 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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