Active Recombinant Human IL20RB, MIgG2a Fc-tagged

• Cat.No.: IL20RB-211H
• Product Overview: The extracellular domain of human IL-20RB (AAH63696.2)(Asp30-Ala230) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.

Specification

• Description: IL20RB (interleukin 20 receptor beta) is a protein-coding gene. Diseases associated with IL20RB include cblc, and psoriasis, and among its related super-pathways are STAT3 Pathway.
• Source: CHO cell
• Species: Human
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: 48KDa (monomer)
• AA Sequence: Asp30-Ala230
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL20RB interleukin 20 receptor beta [ Homo sapiens ]
• Official Symbol: IL20RB
• Synonyms: IL20RB; interleukin 20 receptor beta; fibronectin type III domain containing 6 , FNDC6; interleukin-20 receptor subunit beta; DIRS1; IL 20R2; MGC34923; IL-20RB; IL-20R-beta; interleukin-20 receptor II; IL-20 receptor subunit beta; fibronectin type III domain containing 6; FNDC6; IL-20R2
• Gene ID: 53833
• mRNA Refseq: NM_144717
• Protein Refseq: NP_653318
• MIM: 605621
• UniProt ID: Q6UXL0
• Chromosome Location: 3q22.3
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: receptor activity

Reviews

08/22/2021

Suitable for co-immunoprecipitation.

03/26/2018

Effective in cell migration assays.

12/25/2017

High purity levels.

Q&As

What are the binding partners of IL20RB in cellular signaling?

IL20RB interacts with IL-20RA and IL-20RB for signaling.

Does IL20RB have a role in cytokine-induced apoptosis?

IL20RB is involved in cytokine-induced apoptosis.

Is IL20RB involved in any autoimmune disorders?

IL20RB is implicated in autoimmune disorders like lupus.

How is IL20RB expression regulated during infection?

IL20RB expression is upregulated during bacterial and viral infections.

What is the functional impact of IL20RB mutations?

IL20RB mutations have a functional impact on cytokine signaling.

What is the role of IL20RB in epithelial barrier function?

IL20RB enhances epithelial barrier function.

How does IL20RB modulate the NF-κB pathway?

IL20RB modulates the NF-κB pathway.

Does IL20RB have any impact on macrophage activation?

IL20RB activates macrophages through NF-κB.

Does IL20RB expression change in different stages of cancer?

IL20RB expression varies in different stages of cancer.

How does IL20RB contribute to immune response regulation?

IL20RB contributes to immune response regulation by modulating cytokine signaling.