Recombinant Human IL-19
Cat.No. : | IL19-38H |
Product Overview : | Human IL-19 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. |
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Description : | Interleukin-19 (IL-19) is a cytokine that belongs to the IL-10 family, which includes IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 gene is expressed in resting monocytes and B cells. It is up-regulated in monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide. |
Source : | Yeast |
Species : | Human |
Form : | Lyophilized |
Molecular Mass : | 17.8 kDa |
AA Sequence : | LRRCLISTDM HHIEESFQEI KRAIQAKDTF PNVTILSTLE TLQIIKPLDV CCVTKNLLAF YVDRVFKDHQ EPNPKILRKI SSIANSFLYM QKTLRQCQEQ RQCHCRQEAT NATRVIHDNY DQLEVHAAAI KSLGELDVFL AWINKNHEVM FSA (153) |
Applications : | The Human IL-19 protein can be used in cell culture, as a IL-19 ELISA Standard, and as a Western Blot Control. |
Storage : | -20 C |
Gene Name : | IL19 interleukin 19 [ Homo sapiens ] |
Official Symbol : | IL19 |
Synonyms : | IL19; interleukin 19; interleukin-19; IL 10C; IL 19; MDA1; melanoma differentiation associated protein like protein; NG.1; ZMDA1; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein; IL-10C; |
Gene ID : | 29949 |
mRNA Refseq : | NM_013371 |
Protein Refseq : | NP_037503 |
MIM : | 605687 |
UniProt ID : | Q9UHD0 |
Chromosome Location : | 1q32.2 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
Function : | cytokine activity; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionConfocal microscopy and flow cytometry visualize IL19-induced cellular responses and track receptor internalization upon ligand binding.
Functional assays using immune cell cultures and cytokine profiling assays dissect IL19's impact on immune cell polarization and cytokine secretion.
Biophysical techniques like surface plasmon resonance and analytical ultracentrifugation quantify IL19's binding to IL20RA and IL20RB and reveal receptor complex composition.
Biophysical techniques such as surface plasmon resonance and isothermal titration calorimetry quantify IL19's binding kinetics to its receptor complexes.
CRISPR/Cas9 knockout models and siRNA-mediated knockdown in specific cell types unravel IL19's cell-specific roles.
Neutralizing antibodies, receptor blockade experiments, and in vivo disease models evaluate IL19's suitability as a therapeutic target in inflammatory and autoimmune diseases.
Recombinant protein expression in bacterial or mammalian systems followed by purification allows generation of functional IL19 for various experimental assays.
Reporter gene assays, ChIP, and DNA-protein interaction studies probe IL19's transcriptional regulation and interactions with specific DNA sequences.
Animal models and patient samples, combined with histopathology and molecular assays, shed light on IL19's involvement in skin disorders and its therapeutic potential.
Animal wound healing models, in vitro cell migration assays, and co-culture experiments investigate IL19's role in tissue repair and its effects on fibroblast and keratinocyte function.
Customer Reviews (3)
Write a reviewHigh reproducibility.
Suitable for Western blot.
Effective in cell differentiation.
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