"IL17RC" Related Products

Expand

Recombinant Human Interleukin 17 Receptor C, HIgG1 Fc-tagged, mutant

Cat.No.: IL17RC-641H
Product Overview: The extracellular domain of human IL-17RC (NP_116121.2)(Leu21-Ala454) is fused to the N-terminus of the Fc region of a mutant human IgG1was expressed in CHO cell.
Description: This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
Source: CHO cell
Species: Human
Tag: HIgG1 Fc-tagged, mutant
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to bind rhIL-17 in a functional ELISA.
Molecular Mass: 74KDa (monomer)
AA Sequence: Leu21-Ala454
Endotoxin: <0.06 eu/μg as determined by lal>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: IL17RC interleukin 17 receptor C [ Homo sapiens ]
Official Symbol: IL17RC
Synonyms: IL17RC; interleukin 17 receptor C; interleukin-17 receptor C; IL17 RL; IL-17RL; IL17Rhom; zcytoR14; IL17F receptor; IL-17 receptor C; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; IL17RL; IL17-RL; FLJ95963; FLJ96005; MGC10763;
Gene ID: 84818
mRNA Refseq: NM_001203263
Protein Refseq: NP_001190192
MIM: 610925
UniProt ID: Q8NAC3
Chromosome Location: 3p25.3
Function: receptor activity;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.