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Recombinant Human IL23R Protein (Met1-Asp353), His-tagged

Cat.No.: IL23R-589H
Product Overview: Recombinant Human IL23R Protein (AAM44229.1) (Met1-Asp353) was produced by HEK293 Cells expression system. This protein was expressed with a polyhistidine tag at the C-terminus.
Description: IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.
Source: HEK293
Species: Human
Tag : His
Predicted N Terminal: Gly 24
Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass: The recombinant human IL23R consists of 341 amino acids and predicts a molecular mass of 39.3 kDa.
Protein length: Met1-Asp353
Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
Purity: > 95 % as determined by SDS-PAGE.
Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name: IL23R interleukin 23 receptor [ Homo sapiens ]
Official Symbol: IL23R
Synonyms: IL23R; interleukin 23 receptor; interleukin-23 receptor; IL 23R; IL-23 receptor;
Gene ID: 149233
mRNA Refseq: NM_144701
Protein Refseq: NP_653302
MIM: 607562
UniProt ID: Q5VWK5

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