Active Recombinant Human Iinterleukin 23, Alpha Subunit P19

• Cat.No.: L23A-269H
• Product Overview: Recombinant Human IL23A is expressed inHuman 293 cellsas a heterodimeric glycoprotein composed of two disulfide-linked subunits (p40 cystine linked to p19).

Specification

• Cat. No.: L23A-269H
• Description: Production in Human 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have posttranslational modifications which are not humanlike. This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4 (+) T cells, IL23 preferentially acts on memory CD4 (+) T cells.
• Source: Human 293 cells.
• Endotoxin: Endotoxin-free.
• Purity: >95%. The protein was resolved by SDS polyacrylamide gel electrophoresis and the gelwas stained with Coomassie blue.
• Activity: The specific activity was determined by the dose-dependent secretion of IL-17 from mouse splenocytes activated with 10ng/mL PMA.
• Solubility: It is recommended to reconstitute the lyophilized Bone Morphogenetic Protein-6 in sterile 20mM AcOH (acetic Acid) not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Storage: -20℃.

Gene Information

• Gene Name: IL23A interleukin 23, alpha subunit p19 [Homo sapiens]
• Synonyms: P19; SGRF; IL-23; IL-23A; IL23P19; MGC79388; IL23A ;interleukin-23 subunit alpha ; IL-23-A ; IL-23p19 ; IL-23 subunit alpha ; interleukin 23 p19 subunit ; interleukin-23 subunit p19 ; JKA3 induced upon T-cell activation
• Gene ID: 51561
• mRNA Refseq: NM_ 016584
• Protein Refseq: NP_057668
• MIM: 605580
• UniProt ID: Q9NPF7
• Chromosome Location: 12q13.3
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: cytokine activity; protein binding

Reviews

04/18/2020

Coupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.

12/02/2016

Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.

02/25/2016

Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.

Q&As

Is this bioactive cyno IL-23 heterodimer (p19/p40) or just the cyno IL-23p19 subunit?

Please inquiry our product manager with specific product.

Are there any FDA-approved drugs targeting IL23A?

Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.

Is IL23A involved in the regulation of adaptive or innate immunity?

IL23A primarily plays a role in regulating the adaptive immune response.

How is IL23A linked to the pathogenesis of ankylosing spondylitis?

IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.

How does IL23A contribute to rheumatoid arthritis?

In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.

How is IL23A involved in inflammatory bowel diseases like Crohn's disease?

IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.